HCSGD entry for KRT8
1. General information
| Official gene symbol | KRT8 |
|---|---|
| Entrez ID | 3856 |
| Gene full name | keratin 8 |
| Other gene symbols | CARD2 CK-8 CK8 CYK8 K2C8 K8 KO |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005198 | Structural molecule activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005654 | Nucleoplasm | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005882 | Intermediate filament | IDA IEA | cellular_component |
| GO:0016010 | Dystrophin-associated glycoprotein complex | IEA | cellular_component |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016363 | Nuclear matrix | IEA | cellular_component |
| GO:0030018 | Z disc | IEA | cellular_component |
| GO:0032403 | Protein complex binding | IEA | molecular_function |
| GO:0033209 | Tumor necrosis factor-mediated signaling pathway | IEA | biological_process |
| GO:0042383 | Sarcolemma | IEA | cellular_component |
| GO:0043034 | Costamere | IEA | cellular_component |
| GO:0045095 | Keratin filament | IEA | cellular_component |
| GO:0045214 | Sarcomere organization | IEA | biological_process |
| GO:0051599 | Response to hydrostatic pressure | IEA | biological_process |
| GO:0051707 | Response to other organism | IEA | biological_process |
| GO:0060706 | Cell differentiation involved in embryonic placenta development | IEA | biological_process |
| GO:0097110 | Scaffold protein binding | IPI | molecular_function |
| GO:0097191 | Extrinsic apoptotic signaling pathway | IEA | biological_process |
| GO:0097284 | Hepatocyte apoptotic process | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5811576080 | 0.1412396603 | 0.9999902473 | 0.7227043740 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2667202632 |
| GSE13712_SHEAR | Down | -0.3225320683 |
| GSE13712_STATIC | Down | -0.1735465112 |
| GSE19018 | Up | 0.4996619215 |
| GSE19899_A1 | Up | 0.0312458756 |
| GSE19899_A2 | Down | -0.3771546902 |
| PubMed_21979375_A1 | Down | -0.2338260650 |
| PubMed_21979375_A2 | Down | -0.3053356216 |
| GSE35957 | Down | -0.3550835374 |
| GSE36640 | Down | -0.2211668833 |
| GSE54402 | Down | -0.2079219581 |
| GSE9593 | Up | 0.3296848545 |
| GSE43922 | Down | -0.7189720497 |
| GSE24585 | Up | 0.1957284326 |
| GSE37065 | Down | -0.0954087881 |
| GSE28863_A1 | Down | -0.0301639835 |
| GSE28863_A2 | Down | -0.1048496053 |
| GSE28863_A3 | Up | 0.2902404762 |
| GSE28863_A4 | Up | 0.1988734370 |
| GSE48662 | Up | 0.2547038265 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Tenecteplase | DB00031 | BTD00019 | BIOD00019 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019995 | Microarray | Functional MTI (Weak) | 20215506 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030226 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20622962 | Downregulated genes included cyclin D2, keratin 8, insulin-like growth factor 2 (IGF2), natriuretic peptide precursor B (NPPB) and cellular retinoic acid binding protein 2 (CRABP2) |
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