HCSGD entry for TNPO1
1. General information
| Official gene symbol | TNPO1 |
|---|---|
| Entrez ID | 3842 |
| Gene full name | transportin 1 |
| Other gene symbols | IPO2 KPNB2 MIP MIP1 TRN |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000060 | Protein import into nucleus, translocation | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006886 | Intracellular protein transport | IEA | biological_process |
| GO:0008139 | Nuclear localization sequence binding | TAS | molecular_function |
| GO:0008536 | Ran GTPase binding | IEA | molecular_function |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0016070 | RNA metabolic process | TAS | biological_process |
| GO:0016071 | MRNA metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.2942349987 | 0.8829031648 | 0.9941997951 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3530781289 |
| GSE13712_SHEAR | Up | 0.3317651695 |
| GSE13712_STATIC | Down | -0.0763537554 |
| GSE19018 | Down | -0.0687103022 |
| GSE19899_A1 | Up | 0.1287286996 |
| GSE19899_A2 | Down | -0.0259499176 |
| PubMed_21979375_A1 | Up | 0.2563472926 |
| PubMed_21979375_A2 | Up | 0.1254520391 |
| GSE35957 | Up | 0.0482600529 |
| GSE36640 | Up | 0.1462016068 |
| GSE54402 | Up | 0.0127391795 |
| GSE9593 | Up | 0.2612613128 |
| GSE43922 | Up | 0.0736753396 |
| GSE24585 | Down | -0.1341998691 |
| GSE37065 | Up | 0.0586035532 |
| GSE28863_A1 | Down | -0.1147682302 |
| GSE28863_A2 | Up | 0.0451728272 |
| GSE28863_A3 | Down | -0.2871801026 |
| GSE28863_A4 | Up | 0.0792620330 |
| GSE48662 | Down | -0.0699993094 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-210-3p | MIMAT0000267 | MIRT003172 | immunoprecipitaion//Microarray//qRT-PCR | Functional MTI (Weak) | 19826008 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT021043 | Proteomics | Functional MTI (Weak) | 21310411 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023181 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025575 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT031064 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032051 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049301 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-18a-5p | MIMAT0000072 | MIRT050674 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052319 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-129-5p | MIMAT0000242 | NA | hsa-miR-129-5p | 19487295 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
