HCSGD entry for KPNA5
1. General information
| Official gene symbol | KPNA5 |
|---|---|
| Entrez ID | 3841 |
| Gene full name | karyopherin alpha 5 (importin alpha 6) |
| Other gene symbols | IPOA6 SRP6 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006606 | Protein import into nucleus | IEA | biological_process |
| GO:0006607 | NLS-bearing protein import into nucleus | TAS | biological_process |
| GO:0008565 | Protein transporter activity | IEA | molecular_function |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.4226734964 | 0.4482642073 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1363135284 |
| GSE13712_SHEAR | Up | 0.2651576873 |
| GSE13712_STATIC | Up | 0.1351327641 |
| GSE19018 | Up | 0.0386815268 |
| GSE19899_A1 | Down | -0.1189385524 |
| GSE19899_A2 | Up | 0.0098702194 |
| PubMed_21979375_A1 | Up | 0.4248851727 |
| PubMed_21979375_A2 | Up | 0.1870788037 |
| GSE35957 | Down | -0.2105622812 |
| GSE36640 | Up | 0.6152233027 |
| GSE54402 | Up | 0.0597749257 |
| GSE9593 | Up | 0.0287654811 |
| GSE43922 | Up | 0.0508634264 |
| GSE24585 | Up | 0.0002035769 |
| GSE37065 | Up | 0.3512266701 |
| GSE28863_A1 | Down | -0.2934624255 |
| GSE28863_A2 | Up | 0.2427190841 |
| GSE28863_A3 | Down | -0.6801007684 |
| GSE28863_A4 | Down | -0.2407942749 |
| GSE48662 | Up | 0.1088503019 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-196a-5p | MIMAT0000226 | MIRT026068 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-192-5p | MIMAT0000222 | MIRT026470 | Microarray | Functional MTI (Weak) | 19074876 |
| hsa-let-7d-5p | MIMAT0000065 | MIRT032180 | Sequencing | Functional MTI (Weak) | 20371350 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26029164 | Furthermore, we investigated the correlated expression patterns of Cdc14B, ESCO1, KPNA5, MAP3K3, and CSIG during cell cycle and senescence progression, which imply the important pathways CSIG regulating cell cycle and senescence |
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