HCSGD entry for KPNA2
1. General information
| Official gene symbol | KPNA2 |
|---|---|
| Entrez ID | 3838 |
| Gene full name | karyopherin alpha 2 (RAG cohort 1, importin alpha 1) |
| Other gene symbols | IPOA1 QIP2 RCH1 SRP1alpha |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000018 | Regulation of DNA recombination | TAS | biological_process |
| GO:0000085 | Mitotic G2 phase | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006259 | DNA metabolic process | TAS | biological_process |
| GO:0006606 | Protein import into nucleus | IEA | biological_process |
| GO:0006607 | NLS-bearing protein import into nucleus | IDA | biological_process |
| GO:0008139 | Nuclear localization sequence binding | IDA | molecular_function |
| GO:0008565 | Protein transporter activity | IEA | molecular_function |
| GO:0016032 | Viral process | IEA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0042826 | Histone deacetylase binding | IPI | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7733505832 | 0.0059145815 | 0.9999902473 | 0.1552120638 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.4795733097 |
| GSE13712_SHEAR | Up | 0.0215651429 |
| GSE13712_STATIC | Up | 0.2169070761 |
| GSE19018 | Down | -0.0880300395 |
| GSE19899_A1 | Down | -0.2361448053 |
| GSE19899_A2 | Down | -0.4440619169 |
| PubMed_21979375_A1 | Down | -0.1790229525 |
| PubMed_21979375_A2 | Down | -0.8215891389 |
| GSE35957 | Down | -1.1578041170 |
| GSE36640 | Down | -1.2848888814 |
| GSE54402 | Down | -0.1057411151 |
| GSE9593 | Down | -0.6518338586 |
| GSE43922 | Up | 0.0003731523 |
| GSE24585 | Up | 0.1397782274 |
| GSE37065 | Down | -0.1819442037 |
| GSE28863_A1 | Down | -0.2088192398 |
| GSE28863_A2 | Up | 0.8790206894 |
| GSE28863_A3 | Down | -1.3002324860 |
| GSE28863_A4 | Up | 0.6749309762 |
| GSE48662 | Down | -0.8442477230 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-193b-3p | MIMAT0002819 | MIRT016443 | Proteomics | Functional MTI (Weak) | 21512034 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031798 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-326 | MIMAT0000756 | MIRT043631 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-342-3p | MIMAT0000753 | MIRT043663 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-181b-5p | MIMAT0000257 | MIRT047247 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-106a-5p | MIMAT0000103 | MIRT048335 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-100-5p | MIMAT0000098 | MIRT048398 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-93-5p | MIMAT0000093 | MIRT048751 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92a-3p | MIMAT0000092 | MIRT049112 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-3p | MIMAT0000071 | MIRT050744 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
