HCSGD entry for KPNA1
1. General information
| Official gene symbol | KPNA1 |
|---|---|
| Entrez ID | 3836 |
| Gene full name | karyopherin alpha 1 (importin alpha 5) |
| Other gene symbols | IPOA5 NPI-1 RCH2 SRP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000018 | Regulation of DNA recombination | TAS | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IEA ISS | cellular_component |
| GO:0005643 | Nuclear pore | TAS | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA TAS | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006309 | Apoptotic DNA fragmentation | TAS | biological_process |
| GO:0006606 | Protein import into nucleus | IEA | biological_process |
| GO:0006607 | NLS-bearing protein import into nucleus | TAS | biological_process |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0006921 | Cellular component disassembly involved in execution phase of apoptosis | TAS | biological_process |
| GO:0008139 | Nuclear localization sequence binding | TAS | molecular_function |
| GO:0008565 | Protein transporter activity | IEA | molecular_function |
| GO:0016032 | Viral process | TAS | biological_process |
| GO:0019058 | Viral life cycle | TAS | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0030425 | Dendrite | ISS | cellular_component |
| GO:0042307 | Positive regulation of protein import into nucleus | ISS | biological_process |
| GO:0075733 | Intracellular transport of virus | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0924983055 | 0.8147258729 | 0.6388656258 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.3051074470 |
| GSE13712_SHEAR | Up | 0.1200540381 |
| GSE13712_STATIC | Up | 0.0804373693 |
| GSE19018 | Down | -0.3979081021 |
| GSE19899_A1 | Up | 0.3442679350 |
| GSE19899_A2 | Up | 0.3715176257 |
| PubMed_21979375_A1 | Down | -0.1827057439 |
| PubMed_21979375_A2 | Up | 0.3460507877 |
| GSE35957 | Up | 0.2333983053 |
| GSE36640 | Up | 0.4475601816 |
| GSE54402 | Down | -0.0764093306 |
| GSE9593 | Up | 0.3354520332 |
| GSE43922 | Up | 0.1606834522 |
| GSE24585 | Up | 0.1995587560 |
| GSE37065 | Up | 0.2040539661 |
| GSE28863_A1 | Down | -0.1184900575 |
| GSE28863_A2 | Up | 0.2687251628 |
| GSE28863_A3 | Down | -0.8298030477 |
| GSE28863_A4 | Down | -0.2245789180 |
| GSE48662 | Up | 0.2709590194 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025234 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-103a-3p | MIMAT0000101 | MIRT027097 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028495 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031732 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031732 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031732 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045073 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
