HCSGD entry for KNG1
1. General information
| Official gene symbol | KNG1 |
|---|---|
| Entrez ID | 3827 |
| Gene full name | kininogen 1 |
| Other gene symbols | BDK BK KNG |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002576 | Platelet degranulation | TAS | biological_process |
| GO:0004869 | Cysteine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | NAS TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006939 | Smooth muscle contraction | TAS | biological_process |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0007162 | Negative regulation of cell adhesion | IDA | biological_process |
| GO:0007204 | Positive regulation of cytosolic calcium ion concentration | IDA | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0007597 | Blood coagulation, intrinsic pathway | TAS | biological_process |
| GO:0008201 | Heparin binding | NAS | molecular_function |
| GO:0008270 | Zinc ion binding | NAS | molecular_function |
| GO:0030168 | Platelet activation | TAS | biological_process |
| GO:0030195 | Negative regulation of blood coagulation | IDA | biological_process |
| GO:0031093 | Platelet alpha granule lumen | TAS | cellular_component |
| GO:0035810 | Positive regulation of urine volume | TAS | biological_process |
| GO:0035815 | Positive regulation of renal sodium excretion | TAS | biological_process |
| GO:0042311 | Vasodilation | IEA | biological_process |
| GO:0043065 | Positive regulation of apoptotic process | NAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6887860530 | 0.9260295847 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0118613886 |
| GSE13712_SHEAR | Down | -0.0405880706 |
| GSE13712_STATIC | Down | -0.0276772874 |
| GSE19018 | Up | 0.1459667414 |
| GSE19899_A1 | Up | 0.1571247594 |
| GSE19899_A2 | Down | -0.0005621396 |
| PubMed_21979375_A1 | Up | 0.1177444664 |
| PubMed_21979375_A2 | Down | -0.0213589375 |
| GSE35957 | Down | -0.0358332912 |
| GSE36640 | Down | -0.0539520575 |
| GSE54402 | Up | 0.0259855006 |
| GSE9593 | Up | 0.0564889166 |
| GSE43922 | Up | 0.0147721946 |
| GSE24585 | Up | 0.1884919668 |
| GSE37065 | Down | -0.0119531182 |
| GSE28863_A1 | Up | 0.0196678782 |
| GSE28863_A2 | Up | 0.0170849406 |
| GSE28863_A3 | Up | 0.0948999924 |
| GSE28863_A4 | Up | 0.0162962191 |
| GSE48662 | Up | 0.1321458236 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-128-3p | MIMAT0000424 | MIRT021957 | Microarray | Functional MTI (Weak) | 17612493 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
