HCSGD entry for ARF6

1. General information

Official gene symbolARF6
Entrez ID382
Gene full nameADP-ribosylation factor 6
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001726RuffleIDAcellular_component
GO:0001889Liver developmentIEAbiological_process
GO:0003924GTPase activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005525GTP bindingTASmolecular_function
GO:0005768EndosomeIDA TAScellular_component
GO:0005769Early endosomeIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886Plasma membraneIDAcellular_component
GO:0005938Cell cortexIDAcellular_component
GO:0006184GTP catabolic processTASbiological_process
GO:0006928Cellular component movementTASbiological_process
GO:0007049Cell cycleIEAbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007264Small GTPase mediated signal transductionIEAbiological_process
GO:0008152Metabolic processTASbiological_process
GO:0015031Protein transportIEAbiological_process
GO:0016020MembraneTAScellular_component
GO:0016192Vesicle-mediated transportTASbiological_process
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030496MidbodyIEAcellular_component
GO:0030838Positive regulation of actin filament polymerizationIMPbiological_process
GO:0030866Cortical actin cytoskeleton organizationIMPbiological_process
GO:0031527Filopodium membraneIDAcellular_component
GO:0031529Ruffle organizationIDAbiological_process
GO:0031996Thioesterase bindingIPImolecular_function
GO:0032154Cleavage furrowIEAcellular_component
GO:0033028Myeloid cell apoptotic processIEAbiological_process
GO:0034394Protein localization to cell surfaceISSbiological_process
GO:0035020Regulation of Rac protein signal transductionIDAbiological_process
GO:0036010Protein localization to endosomeIMPbiological_process
GO:0048261Negative regulation of receptor-mediated endocytosisTASbiological_process
GO:0051301Cell divisionIEAbiological_process
GO:0051489Regulation of filopodium assemblyIDAbiological_process
GO:0055038Recycling endosome membraneIDAcellular_component
GO:0060998Regulation of dendritic spine developmentISSbiological_process
GO:0090004Positive regulation of establishment of protein localization to plasma membraneISSbiological_process
GO:0090162Establishment of epithelial cell polarityIEAbiological_process
GO:0097284Hepatocyte apoptotic processIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.91786395270.05585103150.99999024730.4445282734

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.3198935260
GSE13712_SHEARUp0.0428649547
GSE13712_STATICDown-0.1025852063
GSE19018Down-0.0758969386
GSE19899_A1Down-0.5715399358
GSE19899_A2Down-0.6409745711
PubMed_21979375_A1Down-0.4318618751
PubMed_21979375_A2Down-0.8122450223
GSE35957Down-0.0315456502
GSE36640Down-0.2086045502
GSE54402Up0.0750636206
GSE9593Up0.1665415672
GSE43922Down-0.2865235206
GSE24585Up0.0656989276
GSE37065Up0.0052748171
GSE28863_A1Down-0.1279630163
GSE28863_A2Up0.2456799988
GSE28863_A3Up0.2933087278
GSE28863_A4Up0.1371025680
GSE48662Down-0.4755794276

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

5'-Guanosine-Diphosphate-MonothiophosphateDB01864 EXPT01651
Guanosine-5'-DiphosphateDB04315 EXPT01573
MYRISTIC ACIDDB08231 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-132-3pMIMAT0000426MIRT021729MicroarrayFunctional MTI (Weak)17612493
hsa-miR-128-3pMIMAT0000424MIRT021955MicroarrayFunctional MTI (Weak)17612493
hsa-miR-181a-5pMIMAT0000256MIRT025065MicroarrayFunctional MTI (Weak)17612493
hsa-miR-34a-5pMIMAT0000255MIRT025265ProteomicsFunctional MTI (Weak)21566225
hsa-miR-103a-3pMIMAT0000101MIRT026984SequencingFunctional MTI (Weak)20371350
hsa-miR-30a-5pMIMAT0000087MIRT028421ProteomicsFunctional MTI (Weak)18668040
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23016858ADP-ribosylated proteins as old and new drug targets for anticancer therapy: the example of ARF6
23016858In addition to its involvement in actin remodeling, plasma membrane reorganization and vesicular transport, ARF6 contributes to cancer progression through activation of cell motility and invasion
23016858Consequently, targeting this modification will counteract the pro-invasive effects of ARF6, providing innovative anti-tumor therapy
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