HCSGD entry for KISS1
1. General information
| Official gene symbol | KISS1 |
|---|---|
| Entrez ID | 3814 |
| Gene full name | KiSS-1 metastasis-suppressor |
| Other gene symbols | HH13 KiSS-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0007010 | Cytoskeleton organization | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0016324 | Apical plasma membrane | IEA | cellular_component |
| GO:0031773 | Kisspeptin receptor binding | IEA | molecular_function |
| GO:0033686 | Positive regulation of luteinizing hormone secretion | IEA | biological_process |
| GO:0043005 | Neuron projection | IEA | cellular_component |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043410 | Positive regulation of MAPK cascade | IEA | biological_process |
| GO:0050806 | Positive regulation of synaptic transmission | IEA | biological_process |
| GO:0051482 | Positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway | IEA | biological_process |
| GO:0060112 | Generation of ovulation cycle rhythm | IEA | biological_process |
| GO:0060124 | Positive regulation of growth hormone secretion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8554644504 | 0.0590830288 | 0.9999902473 | 0.4579282686 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0151084116 |
| GSE13712_SHEAR | Up | 0.4175584590 |
| GSE13712_STATIC | Up | 0.2902074211 |
| GSE19018 | Up | 0.1916301509 |
| GSE19899_A1 | Down | -2.2850350700 |
| GSE19899_A2 | Down | -0.3366765607 |
| PubMed_21979375_A1 | Down | -0.4966817433 |
| PubMed_21979375_A2 | Down | -2.1120037525 |
| GSE35957 | Down | -0.0911072594 |
| GSE36640 | Down | -0.0440484019 |
| GSE54402 | Down | -0.1238929635 |
| GSE9593 | Up | 0.1686510109 |
| GSE43922 | Up | 0.0210190918 |
| GSE24585 | Down | -0.0180232110 |
| GSE37065 | Down | -0.1650771117 |
| GSE28863_A1 | Down | -0.2650201806 |
| GSE28863_A2 | Down | -0.0431198703 |
| GSE28863_A3 | Up | 0.2589913739 |
| GSE28863_A4 | Down | -0.0121082267 |
| GSE48662 | Down | -0.0052267889 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24112790 | Aging-related changes in RP3V kisspeptin neurons predate the reduced activation of GnRH neurons during the early reproductive decline in female mice |
| 24112790 | Kisspeptin neurons in the rostral periventricular area of the third ventricle (RP3V) play a key role in relaying the positive feedback effects of estradiol that activate gonadotropin-releasing hormone (GnRH) neurons and drive a surge in the GnRH/luteinizing hormone (LH) level |
| 24112790 | However, the precise role of kisspeptin neurons during female reproductive senescence remains unclear |
| 24112790 | Focusing on middle-aged intact female mice with irregular estrous cycles, we found a parallel decline in c-Fos-positive kisspeptin neurons and c-Fos-positive GnRH neurons at the time of the GnRH/LH surge |
| 24112790 | Furthermore, in kisspeptin neurons, the expression of estrogen receptor alpha (ERalpha), but not progesterone receptor (PR), decreased with age |
| 24112790 | Interestingly, some kisspeptin neurons in the RP3V, but none of the GnRH neurons in the rostral preoptic area (rPOA), had a characteristic cellular senescence in middle-aged mice and old mice |
| 24112790 | These data suggest that, among the groups of neurons involved in reproductive control, the kisspeptin neurons in the RP3V are likely among the earliest to undergo aging processes and thus participate in initiating the early reproductive decline |
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