HCSGD entry for KCNJ2
1. General information
| Official gene symbol | KCNJ2 |
|---|---|
| Entrez ID | 3759 |
| Gene full name | potassium inwardly-rectifying channel, subfamily J, member 2 |
| Other gene symbols | ATFB9 HHBIRK1 HHIRK1 IRK1 KIR2.1 LQT7 SQT3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005242 | Inward rectifier potassium channel activity | IDA | molecular_function |
| GO:0005546 | Phosphatidylinositol-4,5-bisphosphate binding | IDA | molecular_function |
| GO:0005790 | Smooth endoplasmic reticulum | IEA | cellular_component |
| GO:0005791 | Rough endoplasmic reticulum | IEA | cellular_component |
| GO:0005794 | Golgi apparatus | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006813 | Potassium ion transport | IDA | biological_process |
| GO:0007268 | Synaptic transmission | TAS | biological_process |
| GO:0008076 | Voltage-gated potassium channel complex | IDA | cellular_component |
| GO:0010107 | Potassium ion import | IDA | biological_process |
| GO:0014704 | Intercalated disc | IEA | cellular_component |
| GO:0014861 | Regulation of skeletal muscle contraction via regulation of action potential | IMP | biological_process |
| GO:0015693 | Magnesium ion transport | IEA | biological_process |
| GO:0030007 | Cellular potassium ion homeostasis | TAS | biological_process |
| GO:0030315 | T-tubule | IEA | cellular_component |
| GO:0031224 | Intrinsic component of membrane | IDA | cellular_component |
| GO:0042802 | Identical protein binding | IEA | molecular_function |
| GO:0043025 | Neuronal cell body | IEA | cellular_component |
| GO:0043197 | Dendritic spine | IEA | cellular_component |
| GO:0051289 | Protein homotetramerization | IDA | biological_process |
| GO:0055119 | Relaxation of cardiac muscle | IMP | biological_process |
| GO:0060075 | Regulation of resting membrane potential | TAS | biological_process |
| GO:0060306 | Regulation of membrane repolarization | IDA | biological_process |
| GO:0071260 | Cellular response to mechanical stimulus | IEA | biological_process |
| GO:0071805 | Potassium ion transmembrane transport | IDA | biological_process |
| GO:0086002 | Cardiac muscle cell action potential involved in contraction | IMP | biological_process |
| GO:0086008 | Voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization | IMP | molecular_function |
| GO:0086011 | Membrane repolarization during action potential | IMP | biological_process |
| GO:0086012 | Membrane depolarization during cardiac muscle cell action potential | TAS | biological_process |
| GO:0086013 | Membrane repolarization during cardiac muscle cell action potential | IMP TAS | biological_process |
| GO:0086091 | Regulation of heart rate by cardiac conduction | IMP | biological_process |
| GO:0090076 | Relaxation of skeletal muscle | IMP | biological_process |
| GO:1901381 | Positive regulation of potassium ion transmembrane transport | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0039100908 | 0.0417272444 | 0.1678915171 | 0.3842519762 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 2.2431395247 |
| GSE13712_SHEAR | Down | -0.3192537086 |
| GSE13712_STATIC | Up | 0.7107859584 |
| GSE19018 | Down | -0.2789482772 |
| GSE19899_A1 | Down | -1.1292236454 |
| GSE19899_A2 | Up | 0.5648885229 |
| PubMed_21979375_A1 | Up | 0.3094362149 |
| PubMed_21979375_A2 | Down | -0.3441457830 |
| GSE35957 | Down | -2.1726668638 |
| GSE36640 | Up | 4.5618494764 |
| GSE54402 | Down | -1.5085548014 |
| GSE9593 | Up | 0.4269205272 |
| GSE43922 | Down | -0.9657009301 |
| GSE24585 | Up | 0.4743071743 |
| GSE37065 | Up | 1.0567123881 |
| GSE28863_A1 | Down | -0.2984717405 |
| GSE28863_A2 | Up | 1.0403889318 |
| GSE28863_A3 | Up | 0.5825918665 |
| GSE28863_A4 | Up | 0.0462861531 |
| GSE48662 | Down | -0.4828190547 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001983 | Luciferase reporter assay//Reporter assay;Other | Functional MTI | 17401374 |
| hsa-miR-1 | MIMAT0000416 | MIRT001983 | Luciferase reporter assay | Functional MTI | 19775284 |
| hsa-miR-1 | MIMAT0000416 | MIRT001983 | qRT-PCR | Functional MTI (Weak) | 21169019 |
| hsa-miR-212-3p | MIMAT0000269 | MIRT007044 | Immunoblot//Luciferase reporter assay//qRT-PCR | Functional MTI | 22880819 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | 1 | hsa-miR-1 | 17401374 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
