HCSGD entry for KCNH2

1. General information

Official gene symbolKCNH2
Entrez ID3757
Gene full namepotassium voltage-gated channel, subfamily H (eag-related), member 2
Other gene symbolsERG1 HERG HERG1 Kv11.1 LQT2 SQT1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000155Phosphorelay sensor kinase activityIEAmolecular_function
GO:0003064Regulation of heart rate by hormoneTASbiological_process
GO:0005242Inward rectifier potassium channel activityIDAmolecular_function
GO:0005249Voltage-gated potassium channel activityIDAmolecular_function
GO:0005251Delayed rectifier potassium channel activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005635Nuclear envelopeIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0007268Synaptic transmissionTASbiological_process
GO:0008076Voltage-gated potassium channel complexIDAcellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0031625Ubiquitin protein ligase bindingIPImolecular_function
GO:0035690Cellular response to drugIDAbiological_process
GO:0042391Regulation of membrane potentialIDAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIPImolecular_function
GO:0055075Potassium ion homeostasisIDAbiological_process
GO:0060048Cardiac muscle contractionIMPbiological_process
GO:0060306Regulation of membrane repolarizationIDAbiological_process
GO:0060307Regulation of ventricular cardiac muscle cell membrane repolarizationIMPbiological_process
GO:0071435Potassium ion exportIDAbiological_process
GO:0071805Potassium ion transmembrane transportIDAbiological_process
GO:0086005Ventricular cardiac muscle cell action potentialIMPbiological_process
GO:0086010Membrane depolarization during action potentialIDAbiological_process
GO:0086011Membrane repolarization during action potentialIDAbiological_process
GO:0086013Membrane repolarization during cardiac muscle cell action potentialIMPbiological_process
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:1901379Regulation of potassium ion transmembrane transportIDAbiological_process
GO:1901380Negative regulation of potassium ion transmembrane transportIDAbiological_process
GO:1901381Positive regulation of potassium ion transmembrane transportIDAbiological_process
GO:1902282Voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarizationIMPmolecular_function
GO:1902303Negative regulation of potassium ion exportIDAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.88395665060.31158684700.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0184076111
GSE13712_SHEARDown-0.0027237377
GSE13712_STATICUp0.0742986181
GSE19018Down-0.1579010149
GSE19899_A1Down-0.3403314615
GSE19899_A2Down-0.1441704557
PubMed_21979375_A1Down-0.0819396215
PubMed_21979375_A2Down-0.4336733768
GSE35957Down-0.0828412960
GSE36640Down-0.0742385143
GSE54402Down-0.2035636344
GSE9593Down-0.1487488352
GSE43922Up0.1453561098
GSE24585Down-0.1399029136
GSE37065Down-0.0886696640
GSE28863_A1Up0.3259035257
GSE28863_A2Up0.2374678341
GSE28863_A3Up0.0487020137
GSE28863_A4Up0.1076910115
GSE48662Up0.0274859274

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

DofetilideDB00204 APRD00367
AmsacrineDB00276 APRD00064
IbutilideDB00308 APRD01025
TerfenadineDB00342 APRD00606
AlfuzosinDB00346 APRD00490
PrazosinDB00457 APRD00020
SotalolDB00489 APRD01230
AstemizoleDB00637 APRD00585
VerapamilDB00661 APRD00335
PimozideDB01100 APRD00218
MiconazoleDB01110 APRD01115
AmiodaroneDB01118 APRD00288
CarvedilolDB01136 APRD00091
DoxepinDB01142 APRD00398
TerazosinDB01162 APRD00667
PropafenoneDB01182 APRD00261
ClarithromycinDB01211 APRD00181
HalofantrineDB01218 APRD00419
DronedaroneDB04855 -
AzimilideDB04957 -
SertindoleDB06144 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-133a-3pMIMAT0000427MIRT004831Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI17344217
hsa-miR-133bMIMAT0000770MIRT004832Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI17344217
hsa-miR-335-5pMIMAT0000765MIRT016707MicroarrayFunctional MTI (Weak)18185580
hsa-miR-7-5pMIMAT0000252MIRT025630MicroarrayFunctional MTI (Weak)19073608
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.