HCSGD entry for AREG
1. General information
| Official gene symbol | AREG |
|---|---|
| Entrez ID | 374 |
| Gene full name | amphiregulin |
| Other gene symbols | AR CRDGF SDGF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0007173 | Epidermal growth factor receptor signaling pathway | IDA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | IDA | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0045740 | Positive regulation of DNA replication | IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0002443106 | 0.9410979750 | 0.0444836601 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.6015292548 |
| GSE13712_SHEAR | Up | 0.4858262296 |
| GSE13712_STATIC | Down | -0.0108934708 |
| GSE19018 | Down | -0.3516095341 |
| GSE19899_A1 | Up | 2.0340956227 |
| GSE19899_A2 | Up | 1.2491278914 |
| PubMed_21979375_A1 | Up | 3.3494796988 |
| PubMed_21979375_A2 | Up | 2.8369081545 |
| GSE35957 | Down | -0.1302566646 |
| GSE36640 | Up | 0.6487063258 |
| GSE54402 | Up | 0.9873602061 |
| GSE9593 | Down | -0.3675939589 |
| GSE43922 | Up | 5.4351209685 |
| GSE24585 | Up | 1.3272276847 |
| GSE37065 | Up | 0.4562776854 |
| GSE28863_A1 | Down | -0.0454930223 |
| GSE28863_A2 | Down | -0.0204667259 |
| GSE28863_A3 | Up | 0.1472447838 |
| GSE28863_A4 | Up | 0.0269491275 |
| GSE48662 | Down | -0.3742735135 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT018541 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25077560 | Here we show in different models of senescence that the metalloprotease A disintegrin and metalloproteinase 17 (ADAM17) is activated and releases the epidermal growth factor receptor ligand amphiregulin and tumor necrosis factor receptor I (TNFRI) from the surface of senescent cells by ectodomain shedding |
| 25077560 | Interestingly, unlike amphiregulin and TNFRI, full-length intercellular adhesion molecule 1 (ICAM1) is released from senescent cells by microvesicles independently of ADAM17 |
| 16424011 | The paracrine-acting proteins fibroblast growth factor 7, hepatocyte growth factor, and amphiregulin (AREG) were elevated in the extracellular environment of senescent prostate fibroblasts |
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