HCSGD entry for GSTK1
1. General information
| Official gene symbol | GSTK1 |
|---|---|
| Entrez ID | 373156 |
| Gene full name | glutathione S-transferase kappa 1 |
| Other gene symbols | GST GST 13-13 GST13 GST13-13 GSTK1-1 hGSTK1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004364 | Glutathione transferase activity | IDA | molecular_function |
| GO:0004602 | Glutathione peroxidase activity | IDA | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005622 | Intracellular | IDA | cellular_component |
| GO:0005743 | Mitochondrial inner membrane | IEA | cellular_component |
| GO:0005759 | Mitochondrial matrix | IEA | cellular_component |
| GO:0005777 | Peroxisome | IDA | cellular_component |
| GO:0006749 | Glutathione metabolic process | IEA | biological_process |
| GO:0015035 | Protein disulfide oxidoreductase activity | IEA | molecular_function |
| GO:0043231 | Intracellular membrane-bounded organelle | IDA | cellular_component |
| GO:0055114 | Oxidation-reduction process | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8153186125 | 0.1362141712 | 0.9999902473 | 0.7115929776 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0878244545 |
| GSE13712_SHEAR | Down | -0.3541883828 |
| GSE13712_STATIC | Down | -0.0396528273 |
| GSE19018 | Down | -0.2530376322 |
| GSE19899_A1 | Down | -0.4436957509 |
| GSE19899_A2 | Down | -0.1859980873 |
| PubMed_21979375_A1 | Up | 0.1488525628 |
| PubMed_21979375_A2 | Down | -0.0886249957 |
| GSE35957 | Down | -0.0433284252 |
| GSE36640 | Up | 0.6933336866 |
| GSE54402 | Down | -0.2996453784 |
| GSE9593 | Down | -0.0339018817 |
| GSE43922 | Down | -0.3585300549 |
| GSE24585 | Up | 0.4062353709 |
| GSE37065 | Up | 0.0049439618 |
| GSE28863_A1 | Up | 0.1392762392 |
| GSE28863_A2 | Up | 0.2831916821 |
| GSE28863_A3 | Down | -0.3627863651 |
| GSE28863_A4 | Down | -0.2092325980 |
| GSE48662 | Down | -0.1144802138 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Glutathione | DB00143 | NUTR00029 | EXPT01650 |
| GLUTATHIONE SULFINATE | DB04700 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022421 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-196a-5p | MIMAT0000226 | MIRT048157 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23988789 | We show that the phototoxic effects of peroxisomal KillerRed induce mitochondria-mediated cell death and that this process can be counteracted by targeted overexpression of a select set of antioxidant enzymes, including peroxisomal glutathione S-transferase kappa 1, superoxide dismutase 1, and mitochondrial catalase |
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