HCSGD entry for JUP

1. General information

Official gene symbolJUP
Entrez ID3728
Gene full namejunction plakoglobin
Other gene symbolsARVD12 CTNNG DP3 DPIII PDGB PKGB
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIKRbiological_process
GO:0000902Cell morphogenesisIBAbiological_process
GO:0002159Desmosome assemblyIDA IEAbiological_process
GO:0003136Negative regulation of heart induction by canonical Wnt signaling pathwayIBAbiological_process
GO:0003181Atrioventricular valve morphogenesisIBAbiological_process
GO:0003308Negative regulation of Wnt signaling pathway involved in heart developmentIBAbiological_process
GO:0003713Transcription coactivator activityIDAmolecular_function
GO:0005198Structural molecule activityIBA IEA NASmolecular_function
GO:0005199Structural constituent of cell wallICmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIMPcellular_component
GO:0005667Transcription factor complexIKRcellular_component
GO:0005737CytoplasmIMPcellular_component
GO:0005829CytosolIEA ISScellular_component
GO:0005856CytoskeletonISScellular_component
GO:0005882Intermediate filamentIEAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0005913Cell-cell adherens junctionIDAcellular_component
GO:0005915Zonula adherensIBA ISScellular_component
GO:0005916Fascia adherensIBA IEAcellular_component
GO:0007016Cytoskeletal anchoring at plasma membraneIBA NASbiological_process
GO:0007369GastrulationIBAbiological_process
GO:0007398Ectoderm developmentIBAbiological_process
GO:0007399Nervous system developmentIBAbiological_process
GO:0009898Cytoplasmic side of plasma membraneIBA IEA ISScellular_component
GO:0014704Intercalated discIDAcellular_component
GO:0015629Actin cytoskeletonIBAcellular_component
GO:0016323Basolateral plasma membraneIBAcellular_component
GO:0016327Apicolateral plasma membraneIEAcellular_component
GO:0016328Lateral plasma membraneIEAcellular_component
GO:0016331Morphogenesis of embryonic epitheliumIBAbiological_process
GO:0016337Cell-cell adhesionIDA IEAbiological_process
GO:0016342Catenin complexIDAcellular_component
GO:0016477Cell migrationIMPbiological_process
GO:0019901Protein kinase bindingIBA IEAmolecular_function
GO:0019903Protein phosphatase bindingIPImolecular_function
GO:0030018Z discIBA IEAcellular_component
GO:0030056HemidesmosomeISScellular_component
GO:0030057DesmosomeIDA IEAcellular_component
GO:0032993Protein-DNA complexIDAcellular_component
GO:0034329Cell junction assemblyTASbiological_process
GO:0034332Adherens junction organizationTASbiological_process
GO:0042127Regulation of cell proliferationIDAbiological_process
GO:0042307Positive regulation of protein import into nucleusIDAbiological_process
GO:0042803Protein homodimerization activityISSmolecular_function
GO:0043588Skin developmentIBA IEAbiological_process
GO:0045216Cell-cell junction organizationTASbiological_process
GO:0045294Alpha-catenin bindingIEA IPImolecular_function
GO:0045296Cadherin bindingIPImolecular_function
GO:0048599Oocyte developmentIBAbiological_process
GO:0050982Detection of mechanical stimulusIDAbiological_process
GO:0051091Positive regulation of sequence-specific DNA binding transcription factor activityIDAbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0071603Endothelial cell-cell adhesionISSbiological_process
GO:0071665Gamma-catenin-TCF7L2 complexIDAcellular_component
GO:0071681Cellular response to indole-3-methanolIDAbiological_process
GO:0086005Ventricular cardiac muscle cell action potentialIMPbiological_process
GO:0086069Bundle of His cell to Purkinje myocyte communicationIMPbiological_process
GO:0086091Regulation of heart rate by cardiac conductionIMPbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayICbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00102504840.96346322710.08642076681.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.2601449239
GSE13712_SHEARUp0.2006301408
GSE13712_STATICDown-0.0924047120
GSE19018Up0.2373017096
GSE19899_A1Up2.3058819822
GSE19899_A2Up1.6063010162
PubMed_21979375_A1Up0.8269535392
PubMed_21979375_A2Up3.9182503442
GSE35957Up0.0964010306
GSE36640Up0.9960333421
GSE54402Down-0.0264485039
GSE9593Down-0.7802685466
GSE43922Up1.0976076509
GSE24585Up0.8224207518
GSE37065Down-0.1601558372
GSE28863_A1Down-0.1062393222
GSE28863_A2Up0.6219474655
GSE28863_A3Up0.3333994703
GSE28863_A4Down-0.0088657271
GSE48662Up0.1144939127

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016884MicroarrayFunctional MTI (Weak)18185580
hsa-miR-155-5pMIMAT0000646MIRT020514ProteomicsFunctional MTI (Weak)18668040
hsa-miR-124-3pMIMAT0000422MIRT022247Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-1MIMAT0000416MIRT023549Proteomics;MicroarrayFunctional MTI (Weak)18668037
hsa-miR-30a-5pMIMAT0000087MIRT028441ProteomicsFunctional MTI (Weak)18668040
hsa-miR-615-3pMIMAT0003283MIRT039967CLASHFunctional MTI (Weak)23622248
hsa-miR-30c-5pMIMAT0000244MIRT047927CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.