HCSGD entry for JUNB

1. General information

Official gene symbolJUNB
Entrez ID3726
Gene full namejun B proto-oncogene
Other gene symbolsAP-1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000785ChromatinTAScellular_component
GO:0000977RNA polymerase II regulatory region sequence-specific DNA bindingIEAmolecular_function
GO:0001570VasculogenesisIEAbiological_process
GO:0001649Osteoblast differentiationIEAbiological_process
GO:0001829Trophectodermal cell differentiationIEAbiological_process
GO:0003677DNA bindingTASmolecular_function
GO:0003690Double-stranded DNA bindingIEAmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003713Transcription coactivator activityTASmolecular_function
GO:0003714Transcription corepressor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005730NucleolusIDAcellular_component
GO:0006351Transcription, DNA-templatedTASbiological_process
GO:0006357Regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0006367Transcription initiation from RNA polymerase II promoterTASbiological_process
GO:0007179Transforming growth factor beta receptor signaling pathwayTASbiological_process
GO:0009416Response to light stimulusIEAbiological_process
GO:0009612Response to mechanical stimulusIEAbiological_process
GO:0010467Gene expressionTASbiological_process
GO:0030316Osteoclast differentiationIEAbiological_process
GO:0032570Response to progesteroneIEAbiological_process
GO:0032870Cellular response to hormone stimulusIEAbiological_process
GO:0033687Osteoblast proliferationIEAbiological_process
GO:0034097Response to cytokineIEAbiological_process
GO:0042493Response to drugIEAbiological_process
GO:0043434Response to peptide hormoneIEAbiological_process
GO:0045597Positive regulation of cell differentiationIEAbiological_process
GO:0045944Positive regulation of transcription from RNA polymerase II promoterTASbiological_process
GO:0046697DecidualizationIEAbiological_process
GO:0051412Response to corticosteroneIEAbiological_process
GO:0051591Response to cAMPIEAbiological_process
GO:0051726Regulation of cell cycleIEAbiological_process
GO:0060136Embryonic process involved in female pregnancyIEAbiological_process
GO:0060716Labyrinthine layer blood vessel developmentIEAbiological_process
GO:0071277Cellular response to calcium ionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00082289430.44687605330.07972205881.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-1.9561883120
GSE13712_SHEARUp0.1281608176
GSE13712_STATICUp0.1142423100
GSE19018Down-1.0989215449
GSE19899_A1Up1.0889866820
GSE19899_A2Up1.0672180985
PubMed_21979375_A1Up1.5923780661
PubMed_21979375_A2Up2.1292821058
GSE35957Up0.0983710533
GSE36640Up0.0294583823
GSE54402Up0.6552685817
GSE9593Down-0.5720346973
GSE43922Up1.1439649213
GSE24585Up1.0969309333
GSE37065Up0.1991365195
GSE28863_A1Up1.2820735701
GSE28863_A2Up0.4137247219
GSE28863_A3Down-0.2830645986
GSE28863_A4Up0.2745579954
GSE48662Up0.7120140100

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-199a-3pMIMAT0000232MIRT000783Microarray//Northern blotFunctional MTI (Weak)16331254
hsa-miR-199a-5pMIMAT0000231MIRT004391Microarray//Northern blotFunctional MTI (Weak)16331254
hsa-miR-663aMIMAT0003326MIRT005353Luciferase reporter assay//Microarray//qRT-PCR//Western blotFunctional MTI20622002
hsa-miR-155-5pMIMAT0000646MIRT020720ProteomicsFunctional MTI (Weak)18668040
hsa-miR-1226-3pMIMAT0005577MIRT036441CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21289643In contrast, JunB was not induced in a majority of human SCC cells
21289643Moreover, exogenous expression of JunB inhibited tumorigenesis driven by Ras or spontaneous human SCC cells
21289643Conversely, the dominant-negative JunB mutant (DNJunB) promoted tumorigenesis, which is in contrast to the tumor-suppressor function of the corresponding c-Jun mutant
21289643At the cellular level, JunB induced epidermal cell senescence and slowed cell growth in a cell-autonomous manner
21289643Consistently, coexpression of JunB and Ras induced premature epidermal differentiation concomitant with upregulation of p16 and filaggrin and downregulation of cyclin D1 and cyclin-dependent kinase 4 (CDK4)
21289643These findings indicate that JunB and c-Jun differentially regulate cell growth and differentiation and induce opposite effects on epidermal neoplasia
19340300Of these, 56 are annotated as transcription factors, including two previously reported activators of the locus, ETS2 and JUNB
18628455Function of JunB in transient amplifying cell senescence and progression of human prostate cancer
18628455CONCLUSIONS: JunB is an essential upstream regulator of p16 and contributes to maintain cell senescence that blocks malignant transformation of TAC
18628455JunB thus apparently plays an important role in controlling prostate carcinogenesis and may be a new target for cancer prevention and therapy
18316603The stress-induced translocation of alternative reading frame (ARF) is JNK dependent and mediated by two activator proteins, c-Jun and JunB
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