HCSGD entry for JARID2
1. General information
| Official gene symbol | JARID2 |
|---|---|
| Entrez ID | 3720 |
| Gene full name | jumonji, AT rich interactive domain 2 |
| Other gene symbols | JMJ |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | IEA | biological_process |
| GO:0001889 | Liver development | IEA | biological_process |
| GO:0003677 | DNA binding | IEA | molecular_function |
| GO:0003682 | Chromatin binding | ISS | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0007417 | Central nervous system development | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | IEA | biological_process |
| GO:0031061 | Negative regulation of histone methylation | ISS | biological_process |
| GO:0032452 | Histone demethylase activity | ISS | molecular_function |
| GO:0035097 | Histone methyltransferase complex | ISS | cellular_component |
| GO:0035098 | ESC/E(Z) complex | IDA | cellular_component |
| GO:0045892 | Negative regulation of transcription, DNA-templated | ISS | biological_process |
| GO:0048536 | Spleen development | IEA | biological_process |
| GO:0048538 | Thymus development | IEA | biological_process |
| GO:0048863 | Stem cell differentiation | ISS | biological_process |
| GO:0051574 | Positive regulation of histone H3-K9 methylation | ISS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1235119942 | 0.6125510581 | 0.7181266181 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0418648683 |
| GSE13712_SHEAR | Down | -0.1955094308 |
| GSE13712_STATIC | Down | -0.1574098246 |
| GSE19018 | Down | -0.0401867461 |
| GSE19899_A1 | Down | -0.5531944321 |
| GSE19899_A2 | Up | 0.5905917074 |
| PubMed_21979375_A1 | Up | 1.0713047431 |
| PubMed_21979375_A2 | Up | 0.9705172330 |
| GSE35957 | Down | -0.0071402007 |
| GSE36640 | Down | -0.6375138290 |
| GSE54402 | Up | 0.2217605088 |
| GSE9593 | Down | -0.3433498896 |
| GSE43922 | Up | 0.2940461570 |
| GSE24585 | Down | -0.1354166717 |
| GSE37065 | Up | 0.5276479391 |
| GSE28863_A1 | Up | 0.1548781046 |
| GSE28863_A2 | Up | 0.1351847381 |
| GSE28863_A3 | Up | 0.1500698365 |
| GSE28863_A4 | Down | -0.0867633762 |
| GSE48662 | Up | 0.4346919687 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-155-5p | MIMAT0000646 | MIRT001075 | qRT-PCR//Luciferase reporter assay | Functional MTI | 19759154 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001075 | Luciferase reporter assay | Functional MTI | 23185331 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT001075 | Reporter assay;Other | Functional MTI | 20584899 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT005834 | Microarray | Functional MTI (Weak) | 21282569 |
| hsa-miR-130b-3p | MIMAT0000691 | MIRT020338 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT030356 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-24-3p | MIMAT0000080 | MIRT030615 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031266 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT032070 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040394 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-let-7c-5p | MIMAT0000064 | MIRT051813 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-125b-5p | MIMAT0000423 | NA | hsa-miR-125b | 18056640 | |||
| hsa-miR-155-5p | MIMAT0000646 | 1 | hsa-miR-155 | 19759154 | |||
| hsa-miR-155-5p | MIMAT0000646 | 2 | hsa-miR-155 | 19759154 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
