HCSGD entry for JAK1
1. General information
| Official gene symbol | JAK1 |
|---|---|
| Entrez ID | 3716 |
| Gene full name | Janus kinase 1 |
| Other gene symbols | JAK1A JAK1B JTK3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004713 | Protein tyrosine kinase activity | EXP TAS | molecular_function |
| GO:0004715 | Non-membrane spanning protein tyrosine kinase activity | IEA | molecular_function |
| GO:0005131 | Growth hormone receptor binding | ISS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005856 | Cytoskeleton | IEA | cellular_component |
| GO:0006468 | Protein phosphorylation | TAS | biological_process |
| GO:0007167 | Enzyme linked receptor protein signaling pathway | IEA | biological_process |
| GO:0012505 | Endomembrane system | IEA | cellular_component |
| GO:0016020 | Membrane | IEA | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0019903 | Protein phosphatase binding | IPI | molecular_function |
| GO:0031730 | CCR5 chemokine receptor binding | IEA | molecular_function |
| GO:0035556 | Intracellular signal transduction | TAS | biological_process |
| GO:0038110 | Interleukin-2-mediated signaling pathway | IDA | biological_process |
| GO:0046677 | Response to antibiotic | IDA | biological_process |
| GO:0046777 | Protein autophosphorylation | IEA | biological_process |
| GO:0060333 | Interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0060334 | Regulation of interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
| GO:0060338 | Regulation of type I interferon-mediated signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1053518103 | 0.8956373200 | 0.6741952346 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1561904681 |
| GSE13712_SHEAR | Up | 0.4871314540 |
| GSE13712_STATIC | Up | 0.1864695610 |
| GSE19018 | Up | 0.2196694994 |
| GSE19899_A1 | Down | -0.2520014236 |
| GSE19899_A2 | Down | -0.1164162945 |
| PubMed_21979375_A1 | Up | 0.2299372819 |
| PubMed_21979375_A2 | Up | 0.1276148980 |
| GSE35957 | Up | 0.4198679018 |
| GSE36640 | Up | 0.0192197922 |
| GSE54402 | Up | 0.0751624137 |
| GSE9593 | Up | 0.4556528559 |
| GSE43922 | Down | -0.0409399754 |
| GSE24585 | Up | 0.4846526859 |
| GSE37065 | Down | -0.0357529077 |
| GSE28863_A1 | Up | 0.3479271627 |
| GSE28863_A2 | Up | 0.4463448989 |
| GSE28863_A3 | Down | -0.0711248480 |
| GSE28863_A4 | Down | -0.2691448792 |
| GSE48662 | Down | -0.1533648088 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Name | Drug | Accession number |
|---|---|---|
| 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE | DB04716 | - |
| 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile | DB08183 | - |
| Ruxolitinib | DB08877 | - |
| Tofacitinib | DB08895 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-17-5p | MIMAT0000070 | MIRT000482 | Luciferase reporter assay//Western blot | Functional MTI | 20299512 |
| hsa-miR-106b-5p | MIMAT0000680 | MIRT020460 | Microarray | Functional MTI (Weak) | 17242205 |
| hsa-miR-128-3p | MIMAT0000424 | MIRT021877 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-23b-3p | MIMAT0000418 | MIRT046312 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-15b-5p | MIMAT0000417 | MIRT046471 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26687007 | Eight weeks-treatment with ruxolitinib, an FDA-approved JAK1/2 inhibitor, reduced circulating activin A, preserved fat mass, reduced lipotoxicity, and increased insulin sensitivity in 22-month-old mice |
| 20699642 | Chemical inhibition of all JAK kinases and RNAi-mediated knock-down of JAK1 suppressed PML expression, implicating JAK/STAT-mediated signaling in regulation of the PML gene |
| 19802007 | JAK1/STAT-activating ligands, interleukin 10 (IL10), IL20, IL24, interferon gamma (IFNgamma), IFNbeta and IL6, were also expressed by senescent cells, supporting autocrine/paracrine activation of JAK1/STAT |
| 19802007 | RNA interference-mediated knockdown of JAK1 abolished expression of ISGs, but not DNA damage signaling or senescence |
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