HCSGD entry for IVL
1. General information
| Official gene symbol | IVL |
|---|---|
| Entrez ID | 3713 |
| Gene full name | involucrin |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001533 | Cornified envelope | IDA IEA | cellular_component |
| GO:0005198 | Structural molecule activity | IDA | molecular_function |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0010224 | Response to UV-B | IDA | biological_process |
| GO:0018149 | Peptide cross-linking | IDA | biological_process |
| GO:0018153 | Isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine | TAS | biological_process |
| GO:0030216 | Keratinocyte differentiation | IDA | biological_process |
| GO:0030674 | Protein binding, bridging | IDA | molecular_function |
| GO:0031424 | Keratinization | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0002769842 | 0.9816322062 | 0.0454074534 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.2144729039 |
| GSE13712_SHEAR | Up | 0.1206290835 |
| GSE13712_STATIC | Up | 0.1115439258 |
| GSE19018 | Up | 0.2112679777 |
| GSE19899_A1 | Up | 0.8331831062 |
| GSE19899_A2 | Up | 7.3072395834 |
| PubMed_21979375_A1 | Up | 8.0276884844 |
| PubMed_21979375_A2 | Up | 8.3109241588 |
| GSE35957 | Down | -0.0497132796 |
| GSE36640 | Up | 0.0265683971 |
| GSE54402 | Up | 2.3246028689 |
| GSE9593 | Up | 0.2570121023 |
| GSE43922 | Up | 0.9803846916 |
| GSE24585 | Up | 0.0018015430 |
| GSE37065 | Down | -0.0128031742 |
| GSE28863_A1 | Down | -0.2027005158 |
| GSE28863_A2 | Up | 0.4264577497 |
| GSE28863_A3 | Down | -0.0758271272 |
| GSE28863_A4 | Down | -0.0162952202 |
| GSE48662 | Up | 0.0782940887 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017980 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26731545 | TE increased collagen-I, involucrin and filaggrin synthesis by 70 |
| 26731545 | TE increased the mRNA expression of collagen-I, elastin, superoxide dismutase (SOD-2), aquaporin-3 (AQP-3), filaggrin, involucrin, transglutaminase in HDF or HaCaT cells, and decreased the mRNA levels of tyrosinase in B16F10 cells |
| 25840344 | Epidermal differentiation markers loricrin, filaggrin, involucrin and transglutaminase, also strongly decreased |
| 25810219 | Collagen-I, elastin and involucrin syntheses in human dermal fibroblasts or keratinocytes were up regulated by AAN-II |
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