HCSGD entry for ITIH4
1. General information
| Official gene symbol | ITIH4 |
|---|---|
| Entrez ID | 3700 |
| Gene full name | inter-alpha-trypsin inhibitor heavy chain family, member 4 |
| Other gene symbols | GP120 H4P IHRP ITI-HC4 ITIHL1 PK-120 PK120 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004866 | Endopeptidase inhibitor activity | TAS | molecular_function |
| GO:0004867 | Serine-type endopeptidase inhibitor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | NAS | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006953 | Acute-phase response | IEP | biological_process |
| GO:0010951 | Negative regulation of endopeptidase activity | TAS | biological_process |
| GO:0030212 | Hyaluronan metabolic process | IEA | biological_process |
| GO:0034097 | Response to cytokine | IEP | biological_process |
| GO:0052548 | Regulation of endopeptidase activity | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9017606132 | 0.8318986513 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0101615836 |
| GSE13712_SHEAR | Up | 0.0440383139 |
| GSE13712_STATIC | Down | -0.0517624898 |
| GSE19018 | Up | 0.0097811522 |
| GSE19899_A1 | Up | 0.0259236076 |
| GSE19899_A2 | Down | -0.0311888363 |
| PubMed_21979375_A1 | Down | -0.0997639250 |
| PubMed_21979375_A2 | Down | -0.0926518654 |
| GSE35957 | Down | -0.0482060748 |
| GSE36640 | Up | 0.1157332921 |
| GSE54402 | Up | 0.0158519196 |
| GSE9593 | Down | -0.0552749722 |
| GSE43922 | - | - |
| GSE24585 | - | - |
| GSE37065 | - | - |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0945500599 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-375 | MIMAT0000728 | MIRT019901 | Microarray | Functional MTI (Weak) | 20215506 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
