HCSGD entry for ITGB4
1. General information
| Official gene symbol | ITGB4 |
|---|---|
| Entrez ID | 3691 |
| Gene full name | integrin, beta 4 |
| Other gene symbols | CD104 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005604 | Basement membrane | IEA | cellular_component |
| GO:0005886 | Plasma membrane | IDA TAS | cellular_component |
| GO:0007155 | Cell adhesion | NAS | biological_process |
| GO:0007160 | Cell-matrix adhesion | IEA | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | IEA | biological_process |
| GO:0007275 | Multicellular organismal development | IEA | biological_process |
| GO:0008305 | Integrin complex | IEA | cellular_component |
| GO:0009611 | Response to wounding | IDA | biological_process |
| GO:0009925 | Basal plasma membrane | IEA | cellular_component |
| GO:0009986 | Cell surface | IDA | cellular_component |
| GO:0030056 | Hemidesmosome | IDA | cellular_component |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0031252 | Cell leading edge | IDA | cellular_component |
| GO:0031581 | Hemidesmosome assembly | IDA IEA TAS | biological_process |
| GO:0034329 | Cell junction assembly | TAS | biological_process |
| GO:0043235 | Receptor complex | IDA | cellular_component |
| GO:0046847 | Filopodium assembly | IEA | biological_process |
| GO:0048870 | Cell motility | IEA IMP | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3395882451 | 0.6166913377 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0543520758 |
| GSE13712_SHEAR | Down | -0.2908161361 |
| GSE13712_STATIC | Down | -0.7175188178 |
| GSE19018 | Up | 0.1258689219 |
| GSE19899_A1 | Down | -0.0283755926 |
| GSE19899_A2 | Up | 0.1733872480 |
| PubMed_21979375_A1 | Down | -0.0388440729 |
| PubMed_21979375_A2 | Down | -0.0235646018 |
| GSE35957 | Up | 0.0423672908 |
| GSE36640 | Up | 0.0721379497 |
| GSE54402 | Down | -0.0228114194 |
| GSE9593 | Up | 0.0149256455 |
| GSE43922 | Up | 0.0757878577 |
| GSE24585 | Up | 0.4658436070 |
| GSE37065 | Down | -0.0126580058 |
| GSE28863_A1 | Down | -0.1272103225 |
| GSE28863_A2 | Down | -0.0057155428 |
| GSE28863_A3 | Up | 0.4025965154 |
| GSE28863_A4 | Up | 0.1702244768 |
| GSE48662 | Down | -0.0200748096 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| R1295 | DB05122 | - |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-1 | MIMAT0000416 | MIRT001362 | pSILAC//Proteomics;Other | Functional MTI (Weak) | 18668040 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT018576 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020864 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-30a-5p | MIMAT0000087 | MIRT028554 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-16-5p | MIMAT0000069 | MIRT031876 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | NA | hsa-miR-204 | 20369013 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24265816 | We have recently identified the interaction between netrin-4 (NTN4) and integrin beta-4 (ITGB4), which promotes glioblastoma cell proliferation via activating AKT-mTOR signaling pathway |
| 24265816 | We report here that the suppression of either ITGB4 or NTN4 in glioblastoma cell lines significantly enhances cellular senescence |
| 24265816 | NTN4 partially inhibited TMZ induced cell senescence and rescued AKT from dephosphorylation in U251MG cells, a cell line bearing decent levels of ITGB4 |
| 24265816 | However, addition of exogenous NTN4 displayed no significant effect on TMZ induced senescence rescue or AKT activation in U87MG cells, which expressed ITGB4 at low levels |
| 24265816 | Furthermore, overexpression of ITGB4 combined with exogenous NTN4 significantly attenuated U87MG cell senescence induced by TMZ |
| 24265816 | These data suggest that NTN4 protects glioblastoma cells from TMZ induced senescence, probably via rescuing TMZ triggered ITGB4 dependent AKT dephosphorylation |
| 24265816 | This suggests that interfering the interaction between NTN4 and ITGB4 or concomitant use of the inhibitors of the AKT pathway may improve the therapeutic efficiency of TMZ |
| 20509141 | Modulation of vascular endothelial cell senescence by integrin beta4 |
| 20509141 | Previously, we found that integrin beta4 was involved in VEC senescence |
| 20509141 | However, the mechanism underlying VEC senescence mediated by integrin beta4 remains poorly understand |
| 20509141 | In this study, we used a mouse in vivo model and showed that the level of integrin beta4 in the endothelium of mouse thoracic aorta was increased during natural aging and atherosclerosis |
| 20509141 | Knockdown of integrin beta4 could attenuate HUVEC senescent features, including increased interleukin-8 (IL-8) release and decreased endothelial nitric oxide synthase (eNOS) and NO levels and mitochondrial membrane potential in vitro |
| 20509141 | Integrin beta4 might be a potential target for therapy in cardiovascular diseases |
| 19626662 | To understand the mechanism underlying the senescence, we investigated the activity of phosphatidylcholine-specific phospholipase C (PC-PLC) and levels of integrin beta4, caveolin-1 and ROS with BMSC senescence |
| 19626662 | The activity of PC-PLC and levels of integrin beta4, caveolin-1 and ROS increased greatly during cell senescence |
| 19626662 | Moreover, D609 suppressed the elevated levels of integrin beta4, caveolin-1 and ROS |
| 19626662 | The data suggest that PC-PLC is involved in senescence of BMSCs, and its function is associated with integrin beta4, caveolin-1 and ROS |
| 17964297 | Vascular endothelial cell senescence mediated by integrin beta4 in vitro |
| 17964297 | To understand whether integrin beta4 is involved in vascular endothelial cell (VEC) senescence, we examined integrin beta4 level changes, as well as P53 and reactive oxygen species (ROS) levels and alterations of phosphatidylcholine-specific phospholipase C (PC-PLC) activity before and after knocking-down integrin beta4 by small interfering RNA |
| 17964297 | We found integrin beta4, P53 and ROS levels increased significantly, while Ca(2+)-independent PC-PLC activity obviously decreased during VEC senescence |
| 17964297 | On the other hand, integrin beta4 down-regulation attenuated the senescence phenotype and reversed Ca(2+)-independent PC-PLC activity, and P53 and ROS levels |
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