HCSGD entry for ITGB2

1. General information

Official gene symbolITGB2
Entrez ID3689
Gene full nameintegrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Other gene symbolsCD18 LAD LCAMB LFA-1 MAC-1 MF17 MFI7
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001948Glycoprotein bindingIPImolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0004872Receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005886Plasma membraneTAScellular_component
GO:0006915Apoptotic processNASbiological_process
GO:0006954Inflammatory responseNASbiological_process
GO:0007155Cell adhesionTASbiological_process
GO:0007159Leukocyte cell-cell adhesionIDAbiological_process
GO:0007160Cell-matrix adhesionIEAbiological_process
GO:0007229Integrin-mediated signaling pathwayIEA NASbiological_process
GO:0007267Cell-cell signalingNASbiological_process
GO:0007275Multicellular organismal developmentIEAbiological_process
GO:0007596Blood coagulationTASbiological_process
GO:0008305Integrin complexIEA NAScellular_component
GO:0008360Regulation of cell shapeNASbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0030593Neutrophil chemotaxisIDAbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0045087Innate immune responseTASbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0050730Regulation of peptidyl-tyrosine phosphorylationIDAbiological_process
GO:0050776Regulation of immune responseTASbiological_process
GO:0050900Leukocyte migrationTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.28294182590.82606295350.98177312151.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0598952907
GSE13712_SHEARDown-0.1055137308
GSE13712_STATICDown-0.0109153919
GSE19018Down-0.0052026558
GSE19899_A1Down-0.0138239243
GSE19899_A2Up0.0914653354
PubMed_21979375_A1Down-0.2372829691
PubMed_21979375_A2Up0.0370658552
GSE35957Up0.2495416618
GSE36640Up0.0471906650
GSE54402Up0.0606271927
GSE9593Down-0.0934213888
GSE43922Up0.0216358580
GSE24585Up0.1868930558
GSE37065Up0.0208226334
GSE28863_A1Down-0.2826421204
GSE28863_A2Up0.2225813692
GSE28863_A3Up0.4028253543
GSE28863_A4Up0.1424244896
GSE48662Up0.6280733710

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-335-5pMIMAT0000765MIRT016972MicroarrayFunctional MTI (Weak)18185580
hsa-miR-146a-5pMIMAT0000449MIRT021220MicroarrayFunctional MTI (Weak)18057241
hsa-miR-26b-5pMIMAT0000083MIRT028899MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.