HCSGD entry for ITGA7
1. General information
| Official gene symbol | ITGA7 |
|---|---|
| Entrez ID | 3679 |
| Gene full name | integrin, alpha 7 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005178 | Integrin binding | IEA | molecular_function |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0005927 | Muscle tendon junction | IEA | cellular_component |
| GO:0007155 | Cell adhesion | IEA | biological_process |
| GO:0007160 | Cell-matrix adhesion | TAS | biological_process |
| GO:0007229 | Integrin-mediated signaling pathway | IEA | biological_process |
| GO:0007517 | Muscle organ development | TAS | biological_process |
| GO:0007519 | Skeletal muscle tissue development | IEA | biological_process |
| GO:0008305 | Integrin complex | IEA | cellular_component |
| GO:0008360 | Regulation of cell shape | IEA | biological_process |
| GO:0009986 | Cell surface | IEA | cellular_component |
| GO:0016477 | Cell migration | IEA | biological_process |
| GO:0030198 | Extracellular matrix organization | TAS | biological_process |
| GO:0031594 | Neuromuscular junction | IEA | cellular_component |
| GO:0034677 | Alpha7-beta1 integrin complex | IEA | cellular_component |
| GO:0042383 | Sarcolemma | IEA | cellular_component |
| GO:0043236 | Laminin binding | IEA | molecular_function |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0046982 | Protein heterodimerization activity | IEA | molecular_function |
| GO:0048514 | Blood vessel morphogenesis | IEA | biological_process |
| GO:0050839 | Cell adhesion molecule binding | IEA | molecular_function |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0671647126 | 0.3435809392 | 0.5580310606 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1000758653 |
| GSE13712_SHEAR | Up | 0.1805785926 |
| GSE13712_STATIC | Down | -0.0877834456 |
| GSE19018 | Up | 0.3287530351 |
| GSE19899_A1 | Down | -0.0099161857 |
| GSE19899_A2 | Down | -0.2176657994 |
| PubMed_21979375_A1 | Down | -0.6443921335 |
| PubMed_21979375_A2 | Down | -0.5199813330 |
| GSE35957 | Up | 0.7213101273 |
| GSE36640 | Down | -0.0937826417 |
| GSE54402 | Down | -0.1090452738 |
| GSE9593 | Up | 0.0838708196 |
| GSE43922 | Down | -0.2152513758 |
| GSE24585 | Up | 0.1543063550 |
| GSE37065 | Down | -0.2021752093 |
| GSE28863_A1 | Up | 0.4104633494 |
| GSE28863_A2 | Up | 0.4926440774 |
| GSE28863_A3 | Up | 0.2900577596 |
| GSE28863_A4 | Up | 0.1923854913 |
| GSE48662 | Up | 1.1918993216 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-615-3p | MIMAT0003283 | MIRT040010 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 23763475 | The present study found that H2 O2 (25-100 mumol/L) decreased iPSC adhesion to matrix proteins and endothelial cells, and downregulated gene expression levels of adhesion-related molecules, such as integrin alpha 7, cadherin 1 and 5, melanoma cell adhesion molecule, vascular cell adhesion molecule 1, and monocyte chemoattractant protein-1 |
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