HCSGD entry for AR
1. General information
| Official gene symbol | AR |
|---|---|
| Entrez ID | 367 |
| Gene full name | androgen receptor |
| Other gene symbols | AIS DHTR HUMARA HYSP1 KD NR3C4 SBMA SMAX1 TFM |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000790 | Nuclear chromatin | IDA | cellular_component |
| GO:0001085 | RNA polymerase II transcription factor binding | IPI | molecular_function |
| GO:0001701 | In utero embryonic development | IEA | biological_process |
| GO:0003073 | Regulation of systemic arterial blood pressure | IEA | biological_process |
| GO:0003677 | DNA binding | NAS | molecular_function |
| GO:0003682 | Chromatin binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IDA | molecular_function |
| GO:0004879 | Ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity | IDA | molecular_function |
| GO:0004882 | Androgen receptor activity | IDA IEA IMP NAS TAS | molecular_function |
| GO:0005102 | Receptor binding | IPI | molecular_function |
| GO:0005496 | Steroid binding | IEA | molecular_function |
| GO:0005497 | Androgen binding | NAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA IEA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005886 | Plasma membrane | IEA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IDA | biological_process |
| GO:0006367 | Transcription initiation from RNA polymerase II promoter | TAS | biological_process |
| GO:0006810 | Transport | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007267 | Cell-cell signaling | TAS | biological_process |
| GO:0007283 | Spermatogenesis | IEA | biological_process |
| GO:0007548 | Sex differentiation | NAS | biological_process |
| GO:0008013 | Beta-catenin binding | IDA IPI TAS | molecular_function |
| GO:0008134 | Transcription factor binding | IPI | molecular_function |
| GO:0008219 | Cell death | IEA | biological_process |
| GO:0008270 | Zinc ion binding | IEA | molecular_function |
| GO:0008283 | Cell proliferation | NAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | IDA | biological_process |
| GO:0008584 | Male gonad development | IEA | biological_process |
| GO:0010467 | Gene expression | TAS | biological_process |
| GO:0016049 | Cell growth | NAS | biological_process |
| GO:0019102 | Male somatic sex determination | IEA | biological_process |
| GO:0019899 | Enzyme binding | IPI | molecular_function |
| GO:0030424 | Axon | IEA | cellular_component |
| GO:0030425 | Dendrite | IEA | cellular_component |
| GO:0030521 | Androgen receptor signaling pathway | IDA | biological_process |
| GO:0030522 | Intracellular receptor signaling pathway | IDA | biological_process |
| GO:0030850 | Prostate gland development | NAS | biological_process |
| GO:0032868 | Response to insulin | IEA | biological_process |
| GO:0033148 | Positive regulation of intracellular estrogen receptor signaling pathway | IEA | biological_process |
| GO:0042327 | Positive regulation of phosphorylation | IMP | biological_process |
| GO:0043234 | Protein complex | IDA | cellular_component |
| GO:0043410 | Positive regulation of MAPK cascade | IEA | biological_process |
| GO:0043565 | Sequence-specific DNA binding | IEA | molecular_function |
| GO:0043568 | Positive regulation of insulin-like growth factor receptor signaling pathway | IEA | biological_process |
| GO:0044212 | Transcription regulatory region DNA binding | IDA | molecular_function |
| GO:0045720 | Negative regulation of integrin biosynthetic process | IDA | biological_process |
| GO:0045726 | Positive regulation of integrin biosynthetic process | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA IMP | biological_process |
| GO:0045945 | Positive regulation of transcription from RNA polymerase III promoter | IDA | biological_process |
| GO:0046983 | Protein dimerization activity | NAS | molecular_function |
| GO:0048638 | Regulation of developmental growth | IEA | biological_process |
| GO:0048645 | Organ formation | IEA | biological_process |
| GO:0048808 | Male genitalia morphogenesis | IEA | biological_process |
| GO:0050680 | Negative regulation of epithelial cell proliferation | IEA | biological_process |
| GO:0050681 | Androgen receptor binding | IEA | molecular_function |
| GO:0050790 | Regulation of catalytic activity | IEA | biological_process |
| GO:0051092 | Positive regulation of NF-kappaB transcription factor activity | IMP | biological_process |
| GO:0051259 | Protein oligomerization | IDA | biological_process |
| GO:0060520 | Activation of prostate induction by androgen receptor signaling pathway | IEA | biological_process |
| GO:0060571 | Morphogenesis of an epithelial fold | IEA | biological_process |
| GO:0060599 | Lateral sprouting involved in mammary gland duct morphogenesis | IEA | biological_process |
| GO:0060685 | Regulation of prostatic bud formation | IEA | biological_process |
| GO:0060736 | Prostate gland growth | IEA | biological_process |
| GO:0060740 | Prostate gland epithelium morphogenesis | IEA | biological_process |
| GO:0060742 | Epithelial cell differentiation involved in prostate gland development | IEA | biological_process |
| GO:0060748 | Tertiary branching involved in mammary gland duct morphogenesis | IEA | biological_process |
| GO:0060749 | Mammary gland alveolus development | IEA | biological_process |
| GO:0070974 | POU domain binding | IEA | molecular_function |
| GO:0090003 | Regulation of establishment of protein localization to plasma membrane | IDA | biological_process |
| GO:2001237 | Negative regulation of extrinsic apoptotic signaling pathway | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5671447779 | 0.0123839558 | 0.9999902473 | 0.2196455219 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.1280560818 |
| GSE13712_SHEAR | Down | -0.6893680082 |
| GSE13712_STATIC | Down | -0.3488663322 |
| GSE19018 | Up | 1.4953954075 |
| GSE19899_A1 | Down | -0.1511691311 |
| GSE19899_A2 | Down | -0.7908694082 |
| PubMed_21979375_A1 | Down | -0.2890869768 |
| PubMed_21979375_A2 | Down | -0.2496315290 |
| GSE35957 | Up | 0.3675894799 |
| GSE36640 | Down | -1.3087316662 |
| GSE54402 | Down | -0.3884640115 |
| GSE9593 | Up | 0.1979944391 |
| GSE43922 | Down | -0.0000703426 |
| GSE24585 | Down | -0.7456308228 |
| GSE37065 | Down | -0.5467004622 |
| GSE28863_A1 | Up | 0.4055759540 |
| GSE28863_A2 | Down | -0.3298486390 |
| GSE28863_A3 | Up | 0.2750974280 |
| GSE28863_A4 | Down | -0.2916794389 |
| GSE48662 | Up | 0.0985540987 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
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- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT006451 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 22386953 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT006451 | Luciferase reporter assay | Functional MTI | 23069658 |
| hsa-miR-488-5p | MIMAT0002804 | MIRT003789 | Luciferase reporter assay//qRT-PCR//Western blot | Functional MTI | 21064106 |
| hsa-miR-488-5p | MIMAT0002804 | MIRT003789 | Luciferase reporter assay//qRT-PCR | Functional MTI | 21710544 |
| hsa-miR-185-5p | MIMAT0000455 | MIRT035517 | Luciferase reporter assay | Functional MTI | 23417242 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT052016 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 12 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27305909 | A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling |
| 27305909 | The androgen receptor (AR) is a transcriptional factor that has a pivotal role in the development of normal and also cancerous prostate |
| 26993046 | The tumor suppressor ING1b is a novel corepressor for the androgen receptor and induces cellular senescence in prostate cancer cells |
| 26993046 | The androgen receptor (AR) signaling is critical for prostate cancer (PCa) progression to the castration-resistant stage with poor clinical outcome |
| 26511486 | Given that human prostate cancer arises from precancerous lesions such as high-grade prostatic intraepithelial neoplasia (HG-PIN), which frequently have lost phosphatase and tensin homolog (PTEN) tumor suppressor permitting phosphatidylinositol-3-OH kinase (PI3K)-protein kinase B (AKT) oncogenic signaling, we tested the efficacy of MSeA to inhibit HG-PIN progression in Pten prostate-specific knockout (KO) mice and assessed the mechanistic involvement of p53-mediated cellular senescence and of the androgen receptor (AR) |
| 25772238 | We found that C/EBPbeta expression is negatively regulated by androgen receptor (AR) activity and that treatment of androgen-sensitive cell lines with anti-androgens increases C/EBPbeta mRNA and protein levels |
| 25216853 | The androgen receptor (AR) and AR-agonists (androgens) are required for the development and progression of the normal prostate as well as PCa |
| 25203674 | A natural androgen receptor antagonist induces cellular senescence in prostate cancer cells |
| 25203674 | Atraric acid (AA) inhibits the transactivation of the androgen receptor (AR) and androgen-mediated growth of AR-expressing human prostate cancer (PCa) cell lines |
| 22403609 | The accepted androgen receptor (AR) role is to promote proliferation and survival of prostate epithelium and thus prostate cancer progression |
| 21677876 | These data demonstrate a previously unrecognized link between inhibition of androgen receptor signaling, down-regulation of S-phase kinase-associated protein 2, and the appearance of secretory, tumor-promoting senescent cells in prostate tumors |
| 20826091 | 20-Aminosteroids as a novel class of selective and complete androgen receptor antagonists and inhibitors of prostate cancer cell growth |
| 20826091 | Here, the synthesis and the evaluation of novel 20-aminosteroids on androgen receptor (AR) activity is reported |
| 17339605 | Importantly, increased expression of IFI16 in LNCaP cells was associated with decreases in the expression of androgen receptor and apoptosis of cells |
| 17339605 | Conversely, knockdown of IFI16 expression in TSA-treated LNCaP cells increased androgen receptor protein levels with concomitant decreases in apoptosis |
| 15355435 | DNA samples were extracted from peripheral blood and analyzed by a methylation-based assay at the androgen receptor locus |
| 12511612 | Role of the promyelocytic leukemia body in the dynamic interaction between the androgen receptor and steroid receptor coactivator-1 in living cells |
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