HCSGD entry for IRF3

1. General information

Official gene symbolIRF3
Entrez ID3661
Gene full nameinterferon regulatory factor 3
Other gene symbols
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIEAbiological_process
GO:0000975Regulatory region DNA bindingIEAmolecular_function
GO:0002224Toll-like receptor signaling pathwayTASbiological_process
GO:0002756MyD88-independent toll-like receptor signaling pathwayTASbiological_process
GO:0003677DNA bindingNASmolecular_function
GO:0003700Sequence-specific DNA binding transcription factor activityIEAmolecular_function
GO:0003712Transcription cofactor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDA IEAcellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0005737CytoplasmIDA IEAcellular_component
GO:0005829CytosolTAScellular_component
GO:0006366Transcription from RNA polymerase II promoterTASbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006974Cellular response to DNA damage stimulusTASbiological_process
GO:0016032Viral processIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0031663Lipopolysaccharide-mediated signaling pathwayIEAbiological_process
GO:0032480Negative regulation of type I interferon productionTASbiological_process
GO:0032481Positive regulation of type I interferon productionTASbiological_process
GO:0032727Positive regulation of interferon-alpha productionIEA ISSbiological_process
GO:0032728Positive regulation of interferon-beta productionISS TASbiological_process
GO:0034138Toll-like receptor 3 signaling pathwayTASbiological_process
GO:0034142Toll-like receptor 4 signaling pathwayTASbiological_process
GO:0035666TRIF-dependent toll-like receptor signaling pathwayTASbiological_process
GO:0039530MDA-5 signaling pathwayTASbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042803Protein homodimerization activityIEA IPImolecular_function
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEAbiological_process
GO:0043330Response to exogenous dsRNAIEAbiological_process
GO:0044212Transcription regulatory region DNA bindingIEAmolecular_function
GO:0045087Innate immune responseTASbiological_process
GO:0045351Type I interferon biosynthetic processIEAbiological_process
GO:0045358Negative regulation of interferon-beta biosynthetic processIEAbiological_process
GO:0050689Negative regulation of defense response to virus by hostIEAbiological_process
GO:0050715Positive regulation of cytokine secretionIEAbiological_process
GO:0051607Defense response to virusIEA ISSbiological_process
GO:0060333Interferon-gamma-mediated signaling pathwayTASbiological_process
GO:0060337Type I interferon signaling pathwayTASbiological_process
GO:0060340Positive regulation of type I interferon-mediated signaling pathwayIEAbiological_process
GO:0071359Cellular response to dsRNAIEAbiological_process
GO:0071888Macrophage apoptotic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.05036656280.95055146080.49141612311.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8206880621
GSE13712_SHEARDown-0.0009973849
GSE13712_STATICDown-0.0621005240
GSE19018Down-0.2783092116
GSE19899_A1Up0.1724478332
GSE19899_A2Up0.4656077473
PubMed_21979375_A1Up0.9375781220
PubMed_21979375_A2Up0.2885236330
GSE35957Down-0.1919913005
GSE36640Down-0.3477644637
GSE54402Up0.3857642292
GSE9593Down-0.1684146678
GSE43922Up0.2178454262
GSE24585Up0.2386070265
GSE37065Up0.1205314233
GSE28863_A1Up0.1200367495
GSE28863_A2Up0.1262297819
GSE28863_A3Up0.1220726630
GSE28863_A4Up0.1395215429
GSE48662Up0.1731258093

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

16513254Interferon regulatory factor 3 activates p53-dependent cell growth inhibition
16513254Interferon regulatory factor 3 (IRF3) is a transcriptional factor that plays a crucial role in activation of innate immunity and inflammation in response to viral infection
16513254We investigated the biological function of IRF3 overexpressed in somatic cells such as fibroblasts and astrocytes
16513254Similar to overexpression of oncogenic H-ras in the normal human fibroblast, overexpression of IRF3 in human fibroblast BJ cells was shown to decrease cell growth and increase senescence-associated beta-galactosidase activity by activating a p53 tumor suppressor
16513254BCNU, a DNA damage agent, further accelerated p53 function and cell death in the IRF3-overexpressed BJ cells compared to control BJ cells, without increased expression of IRF3 target genes
16513254IRF3 failed to activate p53 function and cell growth inhibition in BJ cells downregulating p53 by RNAi-mediated p53 knockdown
16513254Furthermore, enforced expression of IRF3 did not show any effect of cell growth inhibition in astrocytes or embryonic fibroblasts derived from the p53(-/-) mouse
16513254When compared to control BJ cells, BJ cells which downregulated IRF3 by RNAi-mediated IRF3 knockdown showed extended in vitro life span
16513254Taken together, the present study indicates that IRF3 should be a novel inducer of cell growth inhibition and cellular senescence through activation of p53 tumor suppressor
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