HCSGD entry for IRF2
1. General information
| Official gene symbol | IRF2 |
|---|---|
| Entrez ID | 3660 |
| Gene full name | interferon regulatory factor 2 |
| Other gene symbols | IRF-2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000122 | Negative regulation of transcription from RNA polymerase II promoter | TAS | biological_process |
| GO:0000975 | Regulatory region DNA binding | IEA | molecular_function |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003700 | Sequence-specific DNA binding transcription factor activity | IEA IMP | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005654 | Nucleoplasm | TAS | cellular_component |
| GO:0005730 | Nucleolus | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0005925 | Focal adhesion | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006355 | Regulation of transcription, DNA-templated | IMP | biological_process |
| GO:0007596 | Blood coagulation | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0060333 | Interferon-gamma-mediated signaling pathway | TAS | biological_process |
| GO:0060337 | Type I interferon signaling pathway | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0774444246 | 0.5951056875 | 0.5871010081 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0122758886 |
| GSE13712_SHEAR | Down | -0.0028793216 |
| GSE13712_STATIC | Down | -0.1906157932 |
| GSE19018 | Up | 0.8682185823 |
| GSE19899_A1 | Down | -0.0455069506 |
| GSE19899_A2 | Up | 0.5705330539 |
| PubMed_21979375_A1 | Up | 0.4625420014 |
| PubMed_21979375_A2 | Up | 0.3694750448 |
| GSE35957 | Down | -0.4985133123 |
| GSE36640 | Down | -0.6479992012 |
| GSE54402 | Up | 0.0670129151 |
| GSE9593 | Up | 0.2034284600 |
| GSE43922 | Down | -0.1677448719 |
| GSE24585 | Up | 0.6804420692 |
| GSE37065 | Up | 0.3753702247 |
| GSE28863_A1 | Up | 0.2671882056 |
| GSE28863_A2 | Up | 0.4000385928 |
| GSE28863_A3 | Down | -0.2262823032 |
| GSE28863_A4 | Down | -0.2019323757 |
| GSE48662 | Down | -0.1054185034 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017202 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-30d-5p | MIMAT0000245 | MIRT047780 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
