HCSGD entry for IREB2
1. General information
| Official gene symbol | IREB2 |
|---|---|
| Entrez ID | 3658 |
| Gene full name | iron-responsive element binding protein 2 |
| Other gene symbols | ACO3 IRP2 IRP2AD |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003723 | RNA binding | IDA TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005737 | Cytoplasm | NAS | cellular_component |
| GO:0005739 | Mitochondrion | IEA | cellular_component |
| GO:0005829 | Cytosol | IEA | cellular_component |
| GO:0006417 | Regulation of translation | IEA | biological_process |
| GO:0006782 | Protoporphyrinogen IX biosynthetic process | IEA | biological_process |
| GO:0006826 | Iron ion transport | TAS | biological_process |
| GO:0006879 | Cellular iron ion homeostasis | IEA | biological_process |
| GO:0007568 | Aging | IEA | biological_process |
| GO:0008152 | Metabolic process | IEA | biological_process |
| GO:0009791 | Post-embryonic development | IEA | biological_process |
| GO:0010040 | Response to iron(II) ion | IEA | biological_process |
| GO:0030316 | Osteoclast differentiation | IEA | biological_process |
| GO:0030350 | Iron-responsive element binding | IEA TAS | molecular_function |
| GO:0032526 | Response to retinoic acid | IEA | biological_process |
| GO:0034101 | Erythrocyte homeostasis | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0050892 | Intestinal absorption | IEA | biological_process |
| GO:0051539 | 4 iron, 4 sulfur cluster binding | IEA | molecular_function |
| GO:0071456 | Cellular response to hypoxia | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8731553019 | 0.1371915885 | 0.9999902473 | 0.7134992689 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0616145990 |
| GSE13712_SHEAR | Up | 0.3664924859 |
| GSE13712_STATIC | Up | 0.2585327597 |
| GSE19018 | Down | -0.4481538982 |
| GSE19899_A1 | Down | -0.1794796438 |
| GSE19899_A2 | Down | -0.2049847245 |
| PubMed_21979375_A1 | Down | -0.1478966295 |
| PubMed_21979375_A2 | Down | -0.1286762384 |
| GSE35957 | Up | 0.1443657113 |
| GSE36640 | Down | -0.2602377144 |
| GSE54402 | Down | -0.0793928773 |
| GSE9593 | Down | -0.1109049891 |
| GSE43922 | Down | -0.1724677742 |
| GSE24585 | Up | 0.1115305002 |
| GSE37065 | Up | 0.0575259568 |
| GSE28863_A1 | Up | 0.2509647237 |
| GSE28863_A2 | Down | -0.0596448295 |
| GSE28863_A3 | Down | -0.4848094225 |
| GSE28863_A4 | Up | 0.1473939604 |
| GSE48662 | Down | -0.4287862009 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-9-5p | MIMAT0000441 | MIRT021362 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-21-5p | MIMAT0000076 | MIRT030688 | Microarray | Functional MTI (Weak) | 18591254 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040337 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
