HCSGD entry for INSM1

1. General information

Official gene symbolINSM1
Entrez ID3642
Gene full nameinsulinoma-associated 1
Other gene symbolsIA-1 IA1
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0001047Core promoter bindingIDAmolecular_function
GO:0001933Negative regulation of protein phosphorylationIDAbiological_process
GO:0003309Type B pancreatic cell differentiationISSbiological_process
GO:0003310Pancreatic A cell differentiationISSbiological_process
GO:0003323Type B pancreatic cell developmentIEAbiological_process
GO:0003358Noradrenergic neuron developmentISSbiological_process
GO:0003700Sequence-specific DNA binding transcription factor activityIDAmolecular_function
GO:0005634NucleusISScellular_component
GO:0005654NucleoplasmTAScellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0008285Negative regulation of cell proliferationIDAbiological_process
GO:0010468Regulation of gene expressionISSbiological_process
GO:0017053Transcriptional repressor complexIDAcellular_component
GO:0030332Cyclin bindingIPImolecular_function
GO:0031018Endocrine pancreas developmentTASbiological_process
GO:0031490Chromatin DNA bindingIDAmolecular_function
GO:0042421Norepinephrine biosynthetic processISSbiological_process
GO:0042826Histone deacetylase bindingIPImolecular_function
GO:0043254Regulation of protein complex assemblyIDAbiological_process
GO:0045597Positive regulation of cell differentiationISSbiological_process
GO:0046872Metal ion bindingIEAmolecular_function
GO:0060290TransdifferentiationIDAbiological_process
GO:0061104Adrenal chromaffin cell differentiationISSbiological_process
GO:0061549Sympathetic ganglion developmentISSbiological_process
GO:0071158Positive regulation of cell cycle arrestIDAbiological_process
GO:2000179Positive regulation of neural precursor cell proliferationISSbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.38001595680.94720644350.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0445829382
GSE13712_SHEARUp0.0685565681
GSE13712_STATICDown-0.0518310463
GSE19018Up0.0746104134
GSE19899_A1Up0.0912469650
GSE19899_A2Up0.1849369092
PubMed_21979375_A1Up0.0760552499
PubMed_21979375_A2Down-0.0916204349
GSE35957Up0.1102649300
GSE36640Up0.2091427909
GSE54402Up0.1072626215
GSE9593Down-0.0257637604
GSE43922Up0.0868584641
GSE24585Down-0.0099222772
GSE37065Down-0.0986971640
GSE28863_A1Down-0.0189898801
GSE28863_A2Up0.0590468464
GSE28863_A3Up0.4239826815
GSE28863_A4Up0.1545584220
GSE48662Up0.0115524146

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

23030720The mRNA levels of MMP-1, MMP-3 and type I (alpha1) collagen were determined by quantitative real-time PCR
9079631The pattern of WS9-14 gene expression by fibroblasts parallels pro-collagen I-alpha1 expression
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