HCSGD entry for IMPDH1
1. General information
| Official gene symbol | IMPDH1 |
|---|---|
| Entrez ID | 3614 |
| Gene full name | IMP (inosine 5'-monophosphate) dehydrogenase 1 |
| Other gene symbols | IMPD IMPD1 LCA11 RP10 sWSS2608 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0003676 | Nucleic acid binding | IDA | molecular_function |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003723 | RNA binding | IEA | molecular_function |
| GO:0003938 | IMP dehydrogenase activity | IEA | molecular_function |
| GO:0005634 | Nucleus | IDA | cellular_component |
| GO:0005737 | Cytoplasm | IDA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006144 | Purine nucleobase metabolic process | TAS | biological_process |
| GO:0006164 | Purine nucleotide biosynthetic process | IEA | biological_process |
| GO:0006177 | GMP biosynthetic process | IEA | biological_process |
| GO:0009168 | Purine ribonucleoside monophosphate biosynthetic process | TAS | biological_process |
| GO:0030554 | Adenyl nucleotide binding | IEA | molecular_function |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
| GO:0046651 | Lymphocyte proliferation | IEA | biological_process |
| GO:0046872 | Metal ion binding | IEA | molecular_function |
| GO:0055086 | Nucleobase-containing small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1143743057 | 0.3987141712 | 0.6952531409 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2517020357 |
| GSE13712_SHEAR | Down | -0.2740759896 |
| GSE13712_STATIC | Down | -0.1222025163 |
| GSE19018 | Up | 0.0133052065 |
| GSE19899_A1 | Up | 0.2694946259 |
| GSE19899_A2 | Up | 0.5544124406 |
| PubMed_21979375_A1 | Up | 1.6238495839 |
| PubMed_21979375_A2 | Up | 0.6848601420 |
| GSE35957 | Up | 0.0405707617 |
| GSE36640 | Up | 0.0828965405 |
| GSE54402 | Up | 0.1405486299 |
| GSE9593 | Down | -0.0716365486 |
| GSE43922 | Up | 0.2591771334 |
| GSE24585 | Down | -0.4134674483 |
| GSE37065 | Down | -0.2346482137 |
| GSE28863_A1 | Down | -0.0192562903 |
| GSE28863_A2 | Up | 0.4728827553 |
| GSE28863_A3 | Up | 0.4253895888 |
| GSE28863_A4 | Down | -0.4590093103 |
| GSE48662 | Down | -0.2273126213 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| NADH | DB00157 | NUTR00041 | DB01907 | EXPT02287 | DB03527 |
| Mycophenolate mofetil | DB00688 | APRD01602 |
| Ribavirin | DB00811 | APRD00081 | EXPT02825 | DB01693 |
| Mycophenolic acid | DB01024 | APRD01603 | EXPT02208 |
| 6-Chloropurine Riboside, 5'-Monophosphate | DB03948 | EXPT01004 |
| VX-148 | DB06103 | - |
| Mercaptopurine | DB01033 | APRD01096 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29a-3p | MIMAT0000086 | MIRT003737 | Luciferase reporter assay | Non-Functional MTI | 17724173 |
| hsa-miR-1 | MIMAT0000416 | MIRT024021 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-34a-5p | MIMAT0000255 | MIRT025513 | Proteomics | Functional MTI (Weak) | 21566225 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT027238 | Reporter assay | Non-Functional MTI | 17724173 |
| hsa-miR-29b-3p | MIMAT0000100 | MIRT027238 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027855 | Microarray | Functional MTI (Weak) | 19088304 |
| hsa-miR-19b-3p | MIMAT0000074 | MIRT031290 | Sequencing | Functional MTI (Weak) | 20371350 |
| hsa-let-7b-5p | MIMAT0000063 | MIRT032495 | Proteomics | Functional MTI (Weak) | 18668040 |
| hsa-miR-1301-3p | MIMAT0005797 | MIRT036018 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040148 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-28-5p | MIMAT0000085 | MIRT049993 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
