HCSGD entry for ILK

1. General information

Official gene symbolILK
Entrez ID3611
Gene full nameintegrin-linked kinase
Other gene symbolsILK-1 ILK-2 P59 p59ILK
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001658Branching involved in ureteric bud morphogenesisIEAbiological_process
GO:0001954Positive regulation of cell-matrix adhesionIEAbiological_process
GO:0004672Protein kinase activityIEAmolecular_function
GO:0004674Protein serine/threonine kinase activityIDA IEAmolecular_function
GO:0004871Signal transducer activityIEAmolecular_function
GO:0005178Integrin bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005524ATP bindingIEAmolecular_function
GO:0005829CytosolTAScellular_component
GO:0005886Plasma membraneIEAcellular_component
GO:0005911Cell-cell junctionIEAcellular_component
GO:0005925Focal adhesionIEAcellular_component
GO:0006468Protein phosphorylationIDAbiological_process
GO:0006469Negative regulation of protein kinase activityIEAbiological_process
GO:0007050Cell cycle arrestIEAbiological_process
GO:0007160Cell-matrix adhesionTASbiological_process
GO:0007229Integrin-mediated signaling pathwayIDA IEAbiological_process
GO:0007569Cell agingIEAbiological_process
GO:0008283Cell proliferationNASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0010667Negative regulation of cardiac muscle cell apoptotic processIEAbiological_process
GO:0014912Negative regulation of smooth muscle cell migrationIEAbiological_process
GO:0017124SH3 domain bindingIEAmolecular_function
GO:0018105Peptidyl-serine phosphorylationIEAbiological_process
GO:0019901Protein kinase bindingIPImolecular_function
GO:0021675Nerve developmentIEAbiological_process
GO:0022011Myelination in peripheral nervous systemIEAbiological_process
GO:0030017SarcomereIEAcellular_component
GO:0030027LamellipodiumIEAcellular_component
GO:0030335Positive regulation of cell migrationIEAbiological_process
GO:0030513Positive regulation of BMP signaling pathwayIEAbiological_process
GO:0032288Myelin assemblyIEAbiological_process
GO:0032956Regulation of actin cytoskeleton organizationIEAbiological_process
GO:0034329Cell junction assemblyTASbiological_process
GO:0034446Substrate adhesion-dependent cell spreadingIEA IMPbiological_process
GO:0042327Positive regulation of phosphorylationIMPbiological_process
GO:0043025Neuronal cell bodyIEAcellular_component
GO:0043034CostamereIEAcellular_component
GO:0043195Terminal boutonIEAcellular_component
GO:0043198Dendritic shaftIEAcellular_component
GO:0043206Extracellular fibril organizationIEAbiological_process
GO:0043234Protein complexIEAcellular_component
GO:0043406Positive regulation of MAP kinase activityIEAbiological_process
GO:0043491Protein kinase B signalingIEAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0045197Establishment or maintenance of epithelial cell apical/basal polarityIEAbiological_process
GO:0045663Positive regulation of myoblast differentiationIEAbiological_process
GO:0045669Positive regulation of osteoblast differentiationIEAbiological_process
GO:0045773Positive regulation of axon extensionIEAbiological_process
GO:0045893Positive regulation of transcription, DNA-templatedIMPbiological_process
GO:0048662Negative regulation of smooth muscle cell proliferationIEAbiological_process
GO:0048812Neuron projection morphogenesisIEAbiological_process
GO:0050775Positive regulation of dendrite morphogenesisIEAbiological_process
GO:0051291Protein heterooligomerizationIEAbiological_process
GO:0051897Positive regulation of protein kinase B signalingIEAbiological_process
GO:0090263Positive regulation of canonical Wnt signaling pathwayIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.96912112380.01921791730.99999024730.2708311064

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.6098811625
GSE13712_SHEARUp0.0829214193
GSE13712_STATICDown-0.1425556804
GSE19018Down-0.0405208553
GSE19899_A1Down-1.4520187267
GSE19899_A2Down-0.6926539433
PubMed_21979375_A1Down-0.0772617408
PubMed_21979375_A2Down-0.1646596697
GSE35957Down-0.4647386115
GSE36640Down-0.1404535888
GSE54402Down-0.0133679640
GSE9593Up0.0166803040
GSE43922Down-0.3040517317
GSE24585Up0.4124054676
GSE37065Down-0.2091244924
GSE28863_A1Down-0.1603576045
GSE28863_A2Down-0.3333605673
GSE28863_A3Down-0.4580641017
GSE28863_A4Up0.0661467320
GSE48662Down-0.1110036768

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-625-5pMIMAT0003294MIRT006720Immunoblot//Immunohistochemistry//Luciferase reporter assay//qRT-PCRFunctional MTI22677169
hsa-miR-542-3pMIMAT0003389MIRT007009Immunoblot//Immunocytochemistry//Luciferase reporter assayFunctional MTI21860426
hsa-miR-145-5pMIMAT0000437MIRT007180Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23104321
hsa-miR-744-5pMIMAT0004945MIRT037481CLASHFunctional MTI (Weak)23622248
hsa-miR-222-3pMIMAT0000279MIRT046790CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 4 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26583057In this work, we were searching for novel intermediaries in oxidative stress-induced senescence, focusing our interest on integrin-linked kinase (ILK), a scaffold protein at cell-extracellular matrix (ECM) adhesion sites, and on the Klotho gene
25346044Suppression of PINCH-2 resulted in decreased formation of the PINCH-2-IPP (PINCH-2, integrin-linked kinase and alpha-parvin) complex and reciprocally increased formation of the PINCH-1-IPP complex
24213576Decreased p-AKT activity results from repression of integrin-linked kinase (ILK) and phosphoinositide-dependent protein kinase-1 (PDPK1) expression
17234816Integrin-linked kinase induces both senescence-associated alterations and extracellular fibronectin assembly in aging cardiac fibroblasts
17234816Integrin-linked kinase (ILK) is an integrin-binding cytoplasmic protein that is involved in regulating numerous cellular processes and extracellular matrix accumulation
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