HCSGD entry for ILF3
1. General information
| Official gene symbol | ILF3 |
|---|---|
| Entrez ID | 3609 |
| Gene full name | interleukin enhancer binding factor 3, 90kDa |
| Other gene symbols | CBTF DRBF DRBP76 MMP4 MPHOSPH4 MPP4 NF-AT-90 NF110 NF110b NF90 NF90a NF90b NFAR NFAR-1 NFAR2 TCP110 TCP80 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000279 | M phase | NAS | biological_process |
| GO:0003677 | DNA binding | IDA | molecular_function |
| GO:0003723 | RNA binding | NAS | molecular_function |
| GO:0003725 | Double-stranded RNA binding | IDA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005634 | Nucleus | IDA NAS | cellular_component |
| GO:0005730 | Nucleolus | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IDA IEA | cellular_component |
| GO:0005739 | Mitochondrion | IDA | cellular_component |
| GO:0006351 | Transcription, DNA-templated | IEA | biological_process |
| GO:0006468 | Protein phosphorylation | IDA IEA | biological_process |
| GO:0017148 | Negative regulation of translation | IEA ISS | biological_process |
| GO:0030529 | Ribonucleoprotein complex | IDA | cellular_component |
| GO:0045071 | Negative regulation of viral genome replication | IEA ISS | biological_process |
| GO:0045892 | Negative regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IDA | biological_process |
| GO:0051607 | Defense response to virus | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7301344858 | 0.0197604878 | 0.9999902473 | 0.2735574658 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.2342658393 |
| GSE13712_SHEAR | Up | 0.1542542104 |
| GSE13712_STATIC | Down | -0.0232571416 |
| GSE19018 | Down | -0.2765737576 |
| GSE19899_A1 | Down | -0.5391414503 |
| GSE19899_A2 | Down | -0.5888462321 |
| PubMed_21979375_A1 | Down | -0.2568306799 |
| PubMed_21979375_A2 | Down | -0.7575259693 |
| GSE35957 | Down | -0.6717479468 |
| GSE36640 | Down | -1.5278890798 |
| GSE54402 | Up | 0.0562842984 |
| GSE9593 | Down | -0.4197360906 |
| GSE43922 | Down | -0.3585398536 |
| GSE24585 | Down | -0.1898801135 |
| GSE37065 | Down | -0.2240730407 |
| GSE28863_A1 | Up | 0.8375446072 |
| GSE28863_A2 | Up | 0.7143652127 |
| GSE28863_A3 | Up | 0.2467245788 |
| GSE28863_A4 | Up | 0.1815383033 |
| GSE48662 | Down | -0.3288813228 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025730 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-1296-5p | MIMAT0005794 | MIRT036091 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-532-3p | MIMAT0004780 | MIRT037927 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-769-5p | MIMAT0003886 | MIRT039142 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-615-3p | MIMAT0003283 | MIRT040110 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-92b-3p | MIMAT0003218 | MIRT040678 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-484 | MIMAT0002174 | MIRT041999 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-200c-3p | MIMAT0000617 | MIRT044381 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-320a | MIMAT0000510 | MIRT044800 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-186-5p | MIMAT0000456 | MIRT045018 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-149-5p | MIMAT0000450 | MIRT045490 | CLASH | Functional MTI (Weak) | 23622248 |
| hsa-miR-17-5p | MIMAT0000070 | MIRT050983 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26491010 | Senescence-associated Long Non-coding RNA (SALNR) Delays Oncogene-induced Senescence through NF90 Regulation |
| 26491010 | Furthermore, we found that SALNR interacts with NF90 (nuclear factor of activated T-cells, 90 kDa), an RNA-binding protein suppressing miRNA biogenesis |
| 26491010 | Moreover, our data showed that Ras-induced stress promotes NF90 nucleolus translocation and suppresses its ability to suppress senescence-associated miRNA biogenesis, which could be rescued by SALNR overexpression |
| 26491010 | These data suggest that lncRNA SALNR modulates cellular senescence at least partly through changing NF90 activity |
| 23117626 | NF90 coordinately represses the senescence-associated secretory phenotype |
| 23117626 | Using two models of human fibroblast senescence (WI-38 and IDH4 cells), we report the identification of RNA-binding protein NF90 as a post-transcriptional repressor of several SASP factors |
| 23117626 | In 'young', proliferating fibroblasts, NF90 was highly abundant, associated with numerous SASP mRNAs, and inhibited their expression |
| 23117626 | By contrast, senescent cells expressed low levels of NF90, thus allowing SASP factor expression to increase |
| 23117626 | NF90 elicited these effects mainly by repressing the translation of target SASP mRNAs, since silencing NF90 did not increase the steady-state levels of SASP mRNAs but elevated key SASP factors including MCP-1, GROa, IL-6, and IL-8 |
| 23117626 | Our findings indicate that NF90 contributes to maintaining low levels of SASP factors in non-senescent cells, while NF90 reduction in senescent cells allows SASP factor expression to rise |
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