HCSGD entry for TNFRSF9
1. General information
| Official gene symbol | TNFRSF9 |
|---|---|
| Entrez ID | 3604 |
| Gene full name | tumor necrosis factor receptor superfamily, member 9 |
| Other gene symbols | 4-1BB CD137 CDw137 ILA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | IEA | molecular_function |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0006915 | Apoptotic process | TAS | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0019955 | Cytokine binding | IEA | molecular_function |
| GO:0070207 | Protein homotrimerization | IEA | biological_process |
| GO:2001180 | Negative regulation of interleukin-10 secretion | IEA | biological_process |
| GO:2001183 | Negative regulation of interleukin-12 secretion | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3287390335 | 0.6958550207 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0448524559 |
| GSE13712_SHEAR | Up | 0.1513116253 |
| GSE13712_STATIC | Up | 0.3216514617 |
| GSE19018 | Up | 0.1201005068 |
| GSE19899_A1 | Down | -0.0425799245 |
| GSE19899_A2 | Down | -0.0118239936 |
| PubMed_21979375_A1 | Up | 0.2787039200 |
| PubMed_21979375_A2 | Up | 0.0467792922 |
| GSE35957 | Down | -0.2800638861 |
| GSE36640 | Down | -0.2276725645 |
| GSE54402 | Down | -0.1757778293 |
| GSE9593 | Up | 0.0451477768 |
| GSE43922 | Up | 0.3840206367 |
| GSE24585 | Down | -0.2129206930 |
| GSE37065 | Up | 0.3557615705 |
| GSE28863_A1 | Down | -0.0192808412 |
| GSE28863_A2 | Down | -0.1379795348 |
| GSE28863_A3 | Up | 0.3337922392 |
| GSE28863_A4 | Up | 0.0497679803 |
| GSE48662 | Down | -0.0948674957 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017048 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-98-5p | MIMAT0000096 | MIRT027444 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26719346 | Therapeutic response was queried in immunodeficient mice, in mice with CCL5-deficient tumors, and in mice cotreated with CD137 agonist to activate TILs |
| 15130673 | Our data support the view that the accumulation of autolysosomes in senescent lymphocytes might aggravate cellular fragility, leading to apoptosis and necrosis mainly induced by lymphocyte activation |
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