HCSGD entry for AQP3

1. General information

Official gene symbolAQP3
Entrez ID360
Gene full nameaquaporin 3 (Gill blood group)
Other gene symbolsAQP-3 GIL
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002684Positive regulation of immune system processIDAbiological_process
GO:0005215Transporter activityNASmolecular_function
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005911Cell-cell junctionIDAcellular_component
GO:0006810TransportNASbiological_process
GO:0006833Water transportTASbiological_process
GO:0007588ExcretionTASbiological_process
GO:0015250Water channel activityEXP TASmolecular_function
GO:0015254Glycerol channel activityIDAmolecular_function
GO:0015840Urea transportIEAbiological_process
GO:0016021Integral component of membraneICcellular_component
GO:0016323Basolateral plasma membraneIEAcellular_component
GO:0032526Response to retinoic acidIDAbiological_process
GO:0033280Response to vitamin DTASbiological_process
GO:0034219Carbohydrate transmembrane transportIDAbiological_process
GO:0042476OdontogenesisIEPbiological_process
GO:0045616Regulation of keratinocyte differentiationTASbiological_process
GO:0051592Response to calcium ionTASbiological_process
GO:0055085Transmembrane transportTASbiological_process
GO:0070295Renal water absorptionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.39437536570.03988120130.99999024730.3763761563

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.0869860360
GSE13712_SHEARDown-1.0597194359
GSE13712_STATICDown-0.2474531753
GSE19018Down-2.0363797740
GSE19899_A1Down-0.0429740888
GSE19899_A2Down-1.1955686915
PubMed_21979375_A1Down-0.4568151813
PubMed_21979375_A2Down-0.3301919325
GSE35957Down-0.1038802540
GSE36640Up0.5783938327
GSE54402Down-1.7293620263
GSE9593Up0.1973629358
GSE43922Up0.0566207318
GSE24585Up0.7460653438
GSE37065Up0.0269409434
GSE28863_A1Up0.2001265328
GSE28863_A2Up0.3237168299
GSE28863_A3Up0.2289469535
GSE28863_A4Up0.0991184671
GSE48662Up0.0350209536

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-615-3pMIMAT0003283MIRT040256CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26731545TE increased the mRNA expression of collagen-I, elastin, superoxide dismutase (SOD-2), aquaporin-3 (AQP-3), filaggrin, involucrin, transglutaminase in HDF or HaCaT cells, and decreased the mRNA levels of tyrosinase in B16F10 cells
19484468There were measurable differences in the membrane fluctuation characteristics in populations of young and old cells, but there was no significant change in the flickering time series on changing the temperature of an individual cell, by depleting it of ATP, or by competing with the minor water exchange pathway via AQP3 using glycerol
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