HCSGD entry for IL12RB2
1. General information
| Official gene symbol | IL12RB2 |
|---|---|
| Entrez ID | 3595 |
| Gene full name | interleukin 12 receptor, beta 2 |
| Other gene symbols | |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004896 | Cytokine receptor activity | TAS | molecular_function |
| GO:0005887 | Integral component of plasma membrane | TAS | cellular_component |
| GO:0007166 | Cell surface receptor signaling pathway | TAS | biological_process |
| GO:0008284 | Positive regulation of cell proliferation | TAS | biological_process |
| GO:0009897 | External side of plasma membrane | IEA | cellular_component |
| GO:0018108 | Peptidyl-tyrosine phosphorylation | IEA | biological_process |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0019901 | Protein kinase binding | IEA | molecular_function |
| GO:0032496 | Response to lipopolysaccharide | IEA | biological_process |
| GO:0032609 | Interferon-gamma production | IEA | biological_process |
| GO:0032729 | Positive regulation of interferon-gamma production | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.7000221838 | 0.3215298241 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0462876519 |
| GSE13712_SHEAR | Up | 0.0665454181 |
| GSE13712_STATIC | Down | -0.1376735771 |
| GSE19018 | Up | 0.2156298082 |
| GSE19899_A1 | Down | -0.0268989939 |
| GSE19899_A2 | Up | 0.2501834169 |
| PubMed_21979375_A1 | Up | 0.3677706688 |
| PubMed_21979375_A2 | Down | -0.0377342726 |
| GSE35957 | Up | 0.2273304203 |
| GSE36640 | Up | 0.2086515271 |
| GSE54402 | Up | 0.1371686364 |
| GSE9593 | Down | -0.1036517405 |
| GSE43922 | Up | 0.0138019784 |
| GSE24585 | Down | -1.2063098035 |
| GSE37065 | Up | 0.0323553344 |
| GSE28863_A1 | Down | -0.1766640859 |
| GSE28863_A2 | Down | -0.0626792047 |
| GSE28863_A3 | Up | 0.1037637407 |
| GSE28863_A4 | Down | -0.0443397745 |
| GSE48662 | Up | 0.0652271959 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-7-5p | MIMAT0000252 | MIRT025732 | Microarray | Functional MTI (Weak) | 17612493 |
| hsa-miR-625-5p | MIMAT0003294 | MIRT039597 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
