HCSGD entry for IL11
1. General information
| Official gene symbol | IL11 |
|---|---|
| Entrez ID | 3589 |
| Gene full name | interleukin 11 |
| Other gene symbols | AGIF IL-11 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005142 | Interleukin-11 receptor binding | IEA NAS | molecular_function |
| GO:0005576 | Extracellular region | IC | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0005737 | Cytoplasm | IEA | cellular_component |
| GO:0007267 | Cell-cell signaling | IC | biological_process |
| GO:0008083 | Growth factor activity | IDA | molecular_function |
| GO:0008284 | Positive regulation of cell proliferation | IDA IEA | biological_process |
| GO:0030183 | B cell differentiation | NAS | biological_process |
| GO:0030219 | Megakaryocyte differentiation | NAS | biological_process |
| GO:0033138 | Positive regulation of peptidyl-serine phosphorylation | IDA | biological_process |
| GO:0043410 | Positive regulation of MAPK cascade | IDA | biological_process |
| GO:0045444 | Fat cell differentiation | NAS | biological_process |
| GO:0045944 | Positive regulation of transcription from RNA polymerase II promoter | IDA | biological_process |
| GO:0046888 | Negative regulation of hormone secretion | IDA | biological_process |
| GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0030733217 | 0.0404338323 | 0.1498016667 | 0.3794149376 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.8696776294 |
| GSE13712_SHEAR | Up | 0.2286209803 |
| GSE13712_STATIC | Down | -0.0049900430 |
| GSE19018 | Down | -1.9455139676 |
| GSE19899_A1 | Up | 1.4307069212 |
| GSE19899_A2 | Up | 1.7623271350 |
| PubMed_21979375_A1 | Up | 2.5317366026 |
| PubMed_21979375_A2 | Up | 1.0276840539 |
| GSE35957 | Down | -0.7556721629 |
| GSE36640 | Down | -1.4711562925 |
| GSE54402 | Up | 1.9343619969 |
| GSE9593 | Down | -0.7948557524 |
| GSE43922 | Up | 1.1886319544 |
| GSE24585 | Up | 0.2925889946 |
| GSE37065 | Up | 0.2271586300 |
| GSE28863_A1 | Down | -0.3247301643 |
| GSE28863_A2 | Down | -0.3477955953 |
| GSE28863_A3 | Up | 0.3465920687 |
| GSE28863_A4 | Down | -0.1347048317 |
| GSE48662 | Up | 0.8460536955 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-204-5p | MIMAT0000265 | MIRT005829 | ELISA//Microarray | Functional MTI (Weak) | 21282569 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT005829 | Luciferase reporter assay | Functional MTI | 22629385 |
| hsa-miR-211-5p | MIMAT0000268 | MIRT007023 | Luciferase reporter assay | Functional MTI | 22629385 |
| hsa-miR-379-5p | MIMAT0000733 | MIRT007025 | Luciferase reporter assay | Functional MTI | 22629385 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022448 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023653 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 21084274 | Many of these induced mRNA changes are in secreted proteins, IL-6, IL-8, and IL-11 and chemokines CXCL2 and CXCL5, or genes associated with an "inflammatory" phenotype |
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