HCSGD entry for IL10RB
1. General information
| Official gene symbol | IL10RB |
|---|---|
| Entrez ID | 3588 |
| Gene full name | interleukin 10 receptor, beta |
| Other gene symbols | CDW210B CRF2-4 CRFB4 D21S58 D21S66 IL-10R2 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004872 | Receptor activity | TAS | molecular_function |
| GO:0004920 | Interleukin-10 receptor activity | TAS | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0006955 | Immune response | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0016021 | Integral component of membrane | TAS | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | TAS | biological_process |
| GO:0032002 | Interleukin-28 receptor complex | NAS | cellular_component |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.3189450705 | 0.1055343072 | 0.9999902473 | 0.6222599686 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.5505082789 |
| GSE13712_SHEAR | Up | 0.0282029557 |
| GSE13712_STATIC | Up | 0.3165411994 |
| GSE19018 | Up | 0.0868926668 |
| GSE19899_A1 | Down | -0.9977025411 |
| GSE19899_A2 | Down | -0.1656643757 |
| PubMed_21979375_A1 | Down | -1.2486972050 |
| PubMed_21979375_A2 | Down | -0.5239036031 |
| GSE35957 | Up | 0.2187714008 |
| GSE36640 | Up | 1.1818877560 |
| GSE54402 | Down | -0.4461923568 |
| GSE9593 | Up | 0.2419276407 |
| GSE43922 | Down | -0.3569717414 |
| GSE24585 | Up | 0.4045004972 |
| GSE37065 | Up | 0.0047842594 |
| GSE28863_A1 | Up | 0.2987370830 |
| GSE28863_A2 | Up | 0.2398829023 |
| GSE28863_A3 | Down | -0.1330754648 |
| GSE28863_A4 | Down | -0.0158309347 |
| GSE48662 | Up | 0.2722213096 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 22473749 | In this study, we identified high levels of IL-10R2 and IL-22R1 expression on hepatic stellate cells (HSCs), the predominant cell type involved in liver fibrogenesis in response to liver damage |
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