HCSGD entry for AQP1

1. General information

Official gene symbolAQP1
Entrez ID358
Gene full nameaquaporin 1 (Colton blood group)
Other gene symbolsAQP-CHIP CHIP28 CO
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

color bar
This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0003097Renal water transportIDAbiological_process
GO:0005215Transporter activityIEAmolecular_function
GO:0005223Intracellular cGMP activated cation channel activityIDAmolecular_function
GO:0005267Potassium channel activityIMPmolecular_function
GO:0005372Water transmembrane transporter activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005886Plasma membraneIDA TAScellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005903Brush borderIDAcellular_component
GO:0006182CGMP biosynthetic processIDAbiological_process
GO:0006813Potassium ion transportISSbiological_process
GO:0006833Water transportIDA IMP TASbiological_process
GO:0006884Cell volume homeostasisIMPbiological_process
GO:0009925Basal plasma membraneIDAcellular_component
GO:0015079Potassium ion transmembrane transporter activityISSmolecular_function
GO:0015168Glycerol transmembrane transporter activityIDAmolecular_function
GO:0015250Water channel activityEXP IDA IMPmolecular_function
GO:0015670Carbon dioxide transportIDAbiological_process
GO:0015696Ammonium transportIDAbiological_process
GO:0015701Bicarbonate transportTASbiological_process
GO:0015793Glycerol transportIDAbiological_process
GO:0016021Integral component of membraneIEAcellular_component
GO:0016323Basolateral plasma membraneIDAcellular_component
GO:0016324Apical plasma membraneIDAcellular_component
GO:0019725Cellular homeostasisIDAbiological_process
GO:0020003Symbiont-containing vacuoleISScellular_component
GO:0020005Symbiont-containing vacuole membraneIDAcellular_component
GO:0021670Lateral ventricle developmentIEPbiological_process
GO:0022857Transmembrane transporter activityIDAmolecular_function
GO:0030157Pancreatic juice secretionIEPbiological_process
GO:0030184Nitric oxide transmembrane transporter activityIDAmolecular_function
GO:0030185Nitric oxide transportIDAbiological_process
GO:0030950Establishment or maintenance of actin cytoskeleton polarityIMPbiological_process
GO:0031526Brush border membraneIDAcellular_component
GO:0031965Nuclear membraneIDAcellular_component
GO:0033326Cerebrospinal fluid secretionIEPbiological_process
GO:0033554Cellular response to stressIDAbiological_process
GO:0034219Carbohydrate transmembrane transportIDAbiological_process
GO:0034220Ion transmembrane transportIDA IMP ISSbiological_process
GO:0034644Cellular response to UVIDAbiological_process
GO:0035377Transepithelial water transportIDAbiological_process
GO:0035378Carbon dioxide transmembrane transportIDAbiological_process
GO:0035379Carbon dioxide transmembrane transporter activityIDA TASmolecular_function
GO:0042383SarcolemmaIDAcellular_component
GO:0042476OdontogenesisIEPbiological_process
GO:0042493Response to drugIDAbiological_process
GO:0043066Negative regulation of apoptotic processIDAbiological_process
GO:0043154Negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIMPbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045177Apical part of cellIDAcellular_component
GO:0045766Positive regulation of angiogenesisIMPbiological_process
GO:0046878Positive regulation of saliva secretionIMPbiological_process
GO:0048146Positive regulation of fibroblast proliferationIDAbiological_process
GO:0050891Multicellular organismal water homeostasisIEPbiological_process
GO:0051739Ammonia transmembrane transporter activityIDAmolecular_function
GO:0055085Transmembrane transportTASbiological_process
GO:0070301Cellular response to hydrogen peroxideIDAbiological_process
GO:0071241Cellular response to inorganic substanceIDAbiological_process
GO:0071260Cellular response to mechanical stimulusIDAbiological_process
GO:0071280Cellular response to copper ionIDAbiological_process
GO:0071288Cellular response to mercury ionIDAbiological_process
GO:0071300Cellular response to retinoic acidIDAbiological_process
GO:0071320Cellular response to cAMPIDA IEPbiological_process
GO:0071456Cellular response to hypoxiaIDAbiological_process
GO:0071472Cellular response to salt stressIDAbiological_process
GO:0071474Cellular hyperosmotic responseIMPbiological_process
GO:0071549Cellular response to dexamethasone stimulusIDAbiological_process
GO:0071732Cellular response to nitric oxideIDAbiological_process
GO:0071805Potassium ion transmembrane transportIMP ISSbiological_process
GO:0085018Maintenance of symbiont-containing vacuole by hostIMPbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.73140777330.00444315190.99999024730.1354076037

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0092331877
GSE13712_SHEARDown-3.1303768034
GSE13712_STATICDown-4.9022975134
GSE19018Down-0.2142783254
GSE19899_A1Down-0.0952197128
GSE19899_A2Down-0.0529993997
PubMed_21979375_A1Up0.0234369822
PubMed_21979375_A2Down-0.3318391673
GSE35957Down-0.2917876862
GSE36640Down-0.1451013517
GSE54402Down-1.2001408622
GSE9593Down-0.0139465398
GSE43922Up0.0242306295
GSE24585Down-0.0788599175
GSE37065Down-0.7118786232
GSE28863_A1Down-0.2525354954
GSE28863_A2Up0.3802400247
GSE28863_A3Up0.6201735228
GSE28863_A4Down-0.0425562585
GSE48662Up0.7957183891

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-320aMIMAT0000510MIRT006497Luciferase reporter assayFunctional MTI20628061
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24164458We found that IGFBP5 (insulin-like growth factor binding protein 5), PLAT (plasminogen activator), SNAI2 (snail homolog 2), JAG1 (jagged 1), SPRY4 (Sprouty homolog 4), and CD44 were upregulated, whereas CFB (complement factor B), VCAM1 (vascular cell adhesion molecule 1), AQP1 (aquaporin 1), LOXL1 (lysyl oxidase-like 1), and RBPMS (RNA-binding protein with multiple splicing) were down- regulated in both radiation-damaged and old cells
19484468However, pCMBS, which inhibits AQP1, the major water exchange pathway, inhibited flickering in all cells, and yet it was restored by the membrane intercalating species dibutyl phthalate (DBP)
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