HCSGD entry for CXCR1
1. General information
| Official gene symbol | CXCR1 |
|---|---|
| Entrez ID | 3577 |
| Gene full name | chemokine (C-X-C motif) receptor 1 |
| Other gene symbols | C-C C-C-CKR-1 CD128 CD181 CDw128a CKR-1 CMKAR1 IL8R1 IL8RA IL8RBA |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0002407 | Dendritic cell chemotaxis | TAS | biological_process |
| GO:0004918 | Interleukin-8 receptor activity | IDA | molecular_function |
| GO:0004930 | G-protein coupled receptor activity | TAS | molecular_function |
| GO:0004950 | Chemokine receptor activity | TAS | molecular_function |
| GO:0005886 | Plasma membrane | TAS | cellular_component |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0007166 | Cell surface receptor signaling pathway | IDA | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0016020 | Membrane | TAS | cellular_component |
| GO:0016021 | Integral component of membrane | IEA | cellular_component |
| GO:0019221 | Cytokine-mediated signaling pathway | IDA TAS | biological_process |
| GO:0019959 | Interleukin-8 binding | IPI | molecular_function |
| GO:0031623 | Receptor internalization | IDA | biological_process |
| GO:0038112 | Interleukin-8-mediated signaling pathway | IDA | biological_process |
| GO:0070098 | Chemokine-mediated signaling pathway | IDA TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8128103264 | 0.7676182288 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0907620246 |
| GSE13712_SHEAR | Down | -0.0913161349 |
| GSE13712_STATIC | Up | 0.0533619784 |
| GSE19018 | Down | -0.1524883540 |
| GSE19899_A1 | Up | 0.0347506356 |
| GSE19899_A2 | Down | -0.0675545443 |
| PubMed_21979375_A1 | Up | 0.1488456699 |
| PubMed_21979375_A2 | Down | -0.0617652348 |
| GSE35957 | Up | 0.2244020880 |
| GSE36640 | Up | 0.1678373021 |
| GSE54402 | Up | 0.0519870336 |
| GSE9593 | Down | -0.0738125691 |
| GSE43922 | Up | 0.0150501795 |
| GSE24585 | Up | 0.0955741919 |
| GSE37065 | Down | -0.0394321029 |
| GSE28863_A1 | Up | 0.1419531142 |
| GSE28863_A2 | Down | -0.0123524419 |
| GSE28863_A3 | Up | 0.0676655034 |
| GSE28863_A4 | Down | -0.0167844325 |
| GSE48662 | Down | -0.0617783332 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Ketoprofen | DB01009 | APRD01059 | DB05823 | DB05335 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017488 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029277 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26601012 | A regular spectral change related to the cell senescence was found in the ratio of two peaks at 1157 cm(-1) and 1174 cm(-1), which are assigned to C-C, C-N stretching vibrations in proteins and C-H bending vibrations in tyrosine and phenylalanine, respectively |
| 25191991 | RECENT FINDINGS: Studies from the animal models and human beings implicate novel molecular pathways such as Wnts, the chemokines, chemokine (C-X-C motif) ligand 4 and chemokine (C-C motif) ligand 2, and the lipid mediators lysophosphatidic acid and sphingosine-1-phosphate in the pathogenesis of SSc |
| 24691968 | Hydroxytyrosol inhibits chemokine C-C motif ligand 5 mediated aged quiescent fibroblast-induced stimulation of breast cancer cell proliferation |
| 24691968 | Chemokine C-C motif ligand 5 (CCL5) expression was found to be approximately 8-fold higher in old compared to that in young quiescent NHFs, which correlated with an increase in the ERK1/2-cyclin D1 pro-proliferative pathway in MB231 cells |
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