HCSGD entry for IL8
1. General information
| Official gene symbol | IL8 |
|---|---|
| Entrez ID | 3576 |
| Gene full name | interleukin 8 |
| Other gene symbols | CXCL8 GCP-1 GCP1 LECT LUCT LYNAP MDNCF MONAP NAF NAP-1 NAP1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001525 | Angiogenesis | TAS | biological_process |
| GO:0002237 | Response to molecule of bacterial origin | IDA | biological_process |
| GO:0005153 | Interleukin-8 receptor binding | IEA IPI | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006928 | Cellular component movement | TAS | biological_process |
| GO:0006935 | Chemotaxis | TAS | biological_process |
| GO:0006954 | Inflammatory response | TAS | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0007050 | Cell cycle arrest | IDA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0007186 | G-protein coupled receptor signaling pathway | TAS | biological_process |
| GO:0008009 | Chemokine activity | IEA TAS | molecular_function |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0019722 | Calcium-mediated signaling | TAS | biological_process |
| GO:0030155 | Regulation of cell adhesion | IDA | biological_process |
| GO:0030593 | Neutrophil chemotaxis | IEA IGI | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0031623 | Receptor internalization | IDA | biological_process |
| GO:0034976 | Response to endoplasmic reticulum stress | IDA | biological_process |
| GO:0035556 | Intracellular signal transduction | IDA | biological_process |
| GO:0042119 | Neutrophil activation | IEA TAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0044344 | Cellular response to fibroblast growth factor stimulus | IEP | biological_process |
| GO:0045091 | Regulation of single stranded viral RNA replication via double stranded DNA intermediate | IDA | biological_process |
| GO:0045744 | Negative regulation of G-protein coupled receptor protein signaling pathway | IDA | biological_process |
| GO:0048566 | Embryonic digestive tract development | IEP | biological_process |
| GO:0050930 | Induction of positive chemotaxis | IGI | biological_process |
| GO:0071222 | Cellular response to lipopolysaccharide | IDA | biological_process |
| GO:0071347 | Cellular response to interleukin-1 | IEP | biological_process |
| GO:0071356 | Cellular response to tumor necrosis factor | IEP | biological_process |
| GO:0090023 | Positive regulation of neutrophil chemotaxis | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.0000093993 | 0.7830266517 | 0.0115777778 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.8782350696 |
| GSE13712_SHEAR | Up | 2.8855313158 |
| GSE13712_STATIC | Up | 1.7521438747 |
| GSE19018 | Down | -2.6027594393 |
| GSE19899_A1 | Up | 3.7976655295 |
| GSE19899_A2 | Up | 5.1181119276 |
| PubMed_21979375_A1 | Up | 10.1266754643 |
| PubMed_21979375_A2 | Up | 7.9015214315 |
| GSE35957 | Up | 0.0086676998 |
| GSE36640 | Up | 1.8115120650 |
| GSE54402 | Up | 0.6269965293 |
| GSE9593 | Up | 0.7371567647 |
| GSE43922 | Up | 5.9904888766 |
| GSE24585 | Down | -0.0849849127 |
| GSE37065 | Up | 1.3288056909 |
| GSE28863_A1 | Up | 0.2036925110 |
| GSE28863_A2 | Up | 0.5880329701 |
| GSE28863_A3 | Down | -0.1718621536 |
| GSE28863_A4 | Down | -0.1468803094 |
| GSE48662 | Up | 0.4536256624 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-146a-5p | MIMAT0000449 | MIRT004409 | Western blot//Northern blot | Functional MTI | 18504431 |
| hsa-miR-146a-5p | MIMAT0000449 | MIRT004409 | Microarray | Functional MTI (Weak) | 20124483 |
| hsa-miR-204-5p | MIMAT0000265 | MIRT005832 | ELISA//Microarray | Functional MTI (Weak) | 21282569 |
| hsa-miR-335-5p | MIMAT0000765 | MIRT019032 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-155-5p | MIMAT0000646 | MIRT020979 | Western blot | Functional MTI | 21030878 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT023079 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT024086 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
- mirRecord
MicroRNA name | mirBase ID | Target site number | MiRNA mature ID | Test method inter | MiRNA regulation site | Reporter target site | Pubmed ID |
|---|---|---|---|---|---|---|---|
| hsa-miR-17-5p | MIMAT0000070 | 1 | hsa-miR-17-5p | 20406904 |
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6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 68 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 27899899 | Moreover, in the first passages, MSCs were capable to release IL1beta, IL6, and IL8, as well as to produce active MMPs allowing them to migrate |
| 27812125 | Genes-toll-interacting protein (TOLLIP), mitogen-activated protein kinase 9 (MAPK9), interleukin-1beta (IL-1beta), interleukin-8 (IL-8), and chemokine (C-X-C motif) ligand 1 (CXCL1)-related to these two pathways were validated using western blotting |
| 27329245 | In a study of SASP markers, the expressions of IL6 and IL8 were also more upregulated in human non-pathological prostatic glands after ADT than in untreated specimens |
| 27329245 | IL6, IL8, and MMP2 were expressed more strongly in human prostate cancer specimens resected after ADT than in untreated tumors |
| 27311854 | Although gemcitabine also enhanced CXCL8 expression, anti-CXCL8 antibody failed to reduce gemcitabine-induced increases in SA beta-Gal-positive cell numbers |
| 27311854 | These observations would indicate that cell senescence can proceed independently of CXCL8 expression, a characteristic feature of senescence-associated secretion phenotype |
| 27115165 | Expressions of IL-6 and IL-8 in RPE/choroid were analyzed using RT-PCR |
| 27115165 | Expressions of proinflammatory IL-6 and IL-8 were significantly upregulated in RPE/choroid of aged SAMP8 mice |
| 27106773 | To evaluate the expression of markers correlated with cellular senescence and DNA damage (8-hydroxy-2'-deoxy-guanosine (8-OHdG), p53, p21, APE1/Ref-1 (APE1), interleukin (IL-6 and IL-8) in placentas from healthy and pathologic pregnancies |
| 27106773 | In placentas of cases affected by PE, HELLP, or IUGR, there was an increased expression of 8-OHdG, p53, APE1, and IL-6 compared to controls (only IL-8 was significantly decreased in cases) |
| 27106773 | Placentas from pathological pregnancies had an altered expression of 8-OHdG, p53, p21, APE1, IL-6, and IL-8 |
| 26654980 | Senescent cells upregulated the proinflammatory cytokines IL-6 and IL-8, the main markers of the senescence-associated secretory phenotype (SASP) |
| 26506233 | Down-regulation of COX5B in breast cancer cell lines can suppress cell proliferation and induced cell senescence which was accompanied by elevating production of IL-8 and other cytokines |
| 26506233 | Cytokines such as IL-8 secreted by senescent cells may in turn alter the microenvironment which could enhance cell migration |
| 26506233 | These findings may provide a novel paradigm for the treatment which combined anti-cancer drugs with particular cytokine inhibitors such as IL-8 blockers |
| 26433963 | In this report we show that senescent human peritoneal mesothelial cells (HPMCs) alter the secretory profile of ovarian cancer cells (A2780, OVCAR-3, SKOV-3) by increasing the release of four angiogenic agents: CXCL1, CXCL8, HGF, and VEGF |
| 26397719 | In vitro treatment of primary human amnion epithelial cells with 40 muM T-oligos ([TTAGGG]2) that mimic telomere fragments, activated p38MAPK, produced senescence-associated (SA) beta-gal staining and increased interleukin (IL)-6 and IL-8 production compared to cells treated with complementary DNA sequences (Cont-oligos, [AATCCC]2) |
| 26284488 | The search for mediators of senescent HPMC activity showed that increased SW480 cell proliferation was stimulated by IL-6, migration by CXCL8 and CCL2, invasion by IL-6, MMP-3 and uPA, and epithelial-mesenchymal transition by TGF-beta1 |
| 25921542 | Microarray analysis identified differentially regulated genes in response to LPC, which included the components of senescence-associated secretory phenotype (SASP) including interleukin-8 (IL-8), IL-6, transforming growth factor-beta and plasminogen activator inhibitor-1 |
| 25635860 | The mRNAs and proteins of SASP components, such as IL-6 and IL-8, quickly accumulated in SIRT1-depleted cells, and the levels of these factors were also higher than those in control cells, indicating that SIRT1 negatively regulated the expression of SASP factors at the transcriptional level |
| 25635860 | SIRT1 bound to the promoter regions of IL-8 and IL-6, but dissociated from them during cellular senescence |
| 25635860 | The acetylation of Histone H3 (K9) and H4 (K16) of the IL-8 and IL-6 promoter regions gradually increased during cellular senescence |
| 25635535 | Silencing Arg-II or p38alpha in senescent cells recouples eNOS and inhibits IL-6 and IL-8 secretion |
| 25574956 | Markers of T-cell activation and senescence were determined by flow cytometry, and plasma levels of interleukin-6, interleukin-8, and C-reactive protein (CRP) were measured, as was telomere length of peripheral blood mononuclear cells (PBMC) |
| 25572145 | Another observation in the present study is the significant up-regulation of key senescence messaging factors regulated by NF-kappaB namely interleukin (IL)-6, IL-8, high-mobility group protein A (HMGA)1 and B (HMGB)1 in E2-transfected cells treated with TNF-alpha |
| 25548483 | The hepatocyte SASP included characteristic factors such as interleukin (IL)-8 and IL-6, as well as novel components such as SAA4, IL-32 and Fibrinogen, which were validated by qPCR and/or chemokine protein array |
| 25412309 | Moreover, we demonstrate that PKCeta creates a positive loop for reinforcing senescence by increasing the transcription of both IL-6 and IL-6 receptor, whereas the expression of IL-8 is specifically suppressed by PKCeta |
| 25385658 | In addition, Abeta(1-42) upregulated interleukin (IL)-6 and IL-8 gene expression in the RPE-choroid |
| 25257149 | Emphasis was on the influence of egg-oil on cell migration and IL-8 production in HaCaT cells, respiration, mitochondrial membrane potential, reactive oxygen (ROS) production and proliferation in HUVEC and HaCaT cells, cytokine and interleukin production in PBML and UV-light induced damage of FTSM |
| 25220188 | Six genes independently correlated with either age (IL-6, TNFRSF-11B, IGFBP-3, SAA4, and COPG), prognosis (IL-6, SAA4), or the grade of the glioma (IL-6, IL-8, ICAM-1, IGFBP-3, and COPG) |
| 25196711 | Molecule activity was assessed on reactive oxygen species (ROS) production, on superoxide dismutase (SOD) and catalase activities and, finally, on inflammatory factor production IL-6, IL-8 and IL-1beta |
| 25093008 | Large subpopulations of tumor cells expressed the RBL2 pocket protein and senescence associated heterochromatin 1gamma and IL8 receptor beta |
| 25046437 | Interleukin-6 (IL-6) and IL-8 (protein and mRNA) were both increased compared with NHCs and H69s (all P<0 |
| 24828530 | PKD1 is activated by oncogenic Ras expression and PKD1 promotes Ras OIS by mediating inflammatory cytokines interleukin-6 (IL-6) and interleukin-8 (IL-8) via modulation of NF-kappaB activity |
| 24337384 | We identified a conserved TNFR-associated factor 6 (TRAF6) binding motif, which was required for CD158d-induced NF-kappaB activation and IL-8 secretion, TRAF6 association with CD158d, and TRAF6 recruitment to CD158d(+) endosomes in transfected cells |
| 23873025 | Melanoma cells facilitate endothelial gap formation, the first step during tumor transendothelial migration, which is mediated by both adhesion and endogenously produced chemokines (in particular, interleukin-8 (IL-8)) |
| 23873025 | Taken together, these studies provide a rationale for using drug therapies that restore CD82 expression and inhibit IL-8 production to inhibit late-stage melanoma cell extravasation and subsequent metastasis development |
| 23781024 | Senescent cells secrete various growth factors and cytokines, such as IL6 and IL8, which collectively constitute the senescence-associated secretory phenotype (SASP) |
| 23781024 | RNAi-mediated knockdown of IkappaBzeta impaired IL6 and IL8 expression, whereas transgenic IkappaBzeta expression resulted in enhanced SASP cytokine expression |
| 23597430 | Interleukin-8 (IL-8) has been shown to play an important role in tumor growth, angiogenesis, and metastasis, and has close relationship with oxidative stress |
| 23597430 | The objective of this study was to determine if IL-8 might be able to prevent oxidative stress-induced senescence of endothelial cells and the mechanisms |
| 23597430 | Human umbilical vein endothelial cells (HUVECs) were cultured and stimulated with hydrogen peroxide in the absence or presence of IL-8 |
| 23597430 | IL-8 dose-dependently inhibited the onset of HUVEC senescence |
| 23597430 | IL-8 also increased telomerase activity which was accompanied with upregulation of the catalytic subunit, telomerase reverse transcriptase (TERT), whereas these effects were significantly attenuated by SB 225002 (selective non-peptide CXCR2 antagonist) |
| 23597430 | In conclusion, IL-8 exerted protective effects against endothelial senescence, which may be related to the activation of telomerase |
| 23557734 | Expressions of IL-8 and MMPs were analyzed by RT-PCR, ELISA, and gelatin zymography |
| 23557734 | RESULTS: Abeta promotes RPE cells to enter senescence and secrete higher concentrations of IL-8 and MMP-9 |
| 23557734 | Secretion of MMP-9 is associated with compromised barrier integrity and with processing of IL-8 to a more activated form |
| 23385065 | Cellular senescence, a permanent state of cell cycle arrest that provides a barrier against tumorigenesis, is accompanied by elevated proinflammatory cytokines such as IL1, IL6, IL8 and TNFalpha |
| 23117626 | NF90 elicited these effects mainly by repressing the translation of target SASP mRNAs, since silencing NF90 did not increase the steady-state levels of SASP mRNAs but elevated key SASP factors including MCP-1, GROa, IL-6, and IL-8 |
| 22904099 | Compared with young EC, senescent cells displayed increased expression of senescence-associated beta-galactosidase, nitric oxide synthase (eNOS), and AKT kinase, and secreted increased amounts of growth factors (VEGF, TGF-beta), cytokines (IL-6, IL-8, MCP-1), adhesion molecules (sICAM-1), and matrix proteins (fibronectin) |
| 22789011 | Furthermore, hPTTG1 overexpression activated NF-kappaB signaling to transactivate the expression of interleukin (IL)-8 and growth-regulated oncogene alpha (GROalpha) to execute CXCR2 signaling in MCF-7 cells |
| 22374671 | We found that STAT3 was required for the events leading to senescence, including the initial early-phase ROS increase and the induction of IL1alpha/beta, IL6 and CXCL8 mRNAs 4-5 d after IL6/sIL6R stimulation, suggesting that STAT3's role is indirect |
| 22319624 | Both fatty acids appeared to abolish H(2)O(2) mediated stimulation of nuclear factor kappaB and IL-6, but not IL-1alpha and IL-8 |
| 21980054 | Secretion of IL-8, a hallmark of senescence-associated secretary phenotype, was measured by ELISA |
| 21980054 | CKB inhibition alone induced cell senescence, and further enhanced CSE-induced cell senescence and IL-8 secretion |
| 21336305 | We demonstrate that retinoic-acid-inducible gene-I (RIG-I) is induced through the ataxia telangiectasia mutated-interferon regulatory factor 1 (ATM-IRF1) axis in senescent cells and that RIG-I signalling mediates the expression of two important mediators of inflammation, interleukin-6 (IL-6) and IL-8 |
| 21336305 | We show here that the intracellular, but not the secreted, form of klotho interacts with RIG-I and that this interaction inhibits RIG-I-induced expression of IL-6 and IL-8 both in vitro and in vivo |
| 21084274 | Many of these induced mRNA changes are in secreted proteins, IL-6, IL-8, and IL-11 and chemokines CXCL2 and CXCL5, or genes associated with an "inflammatory" phenotype |
| 20937593 | Chromatin immunoprecipitation assay on DNA isolated from IKKbeta immunoprecipitated samples showed PCR amplification of interleukin-8 promoter sequences, a binding site of NFkappaB, indicating an interaction between IKKbeta and NFkappaB |
| 20647331 | In 22Rv1 human prostate cells, but not in Du145 or RWPE-2, PIM1 overexpression was associated with marked increases in cellular senescence, as shown by changes in the levels of beta-galactosidase (SA-beta-Gal), p21, interleukin (IL)-6 and IL-8 mRNA and protein |
| 20509141 | Knockdown of integrin beta4 could attenuate HUVEC senescent features, including increased interleukin-8 (IL-8) release and decreased endothelial nitric oxide synthase (eNOS) and NO levels and mitochondrial membrane potential in vitro |
| 20053980 | Protein levels of IRAK1 and PAI-1 were analyzed by Western blot and those of IL6 and IL8 by ELISA |
| 20016134 | RESULTS: Senescent A549 cells and HDMECs, whether stimulated with lipopolysaccharide or not, produced greater amounts of IL-6, IL-8 and TNF-alpha, which paralleled NF-kappaB activation, than did presenescent cells |
| 19935801 | In addition, these cells secrete higher levels of IL-6 and IL-8 representing key components of the senescence-associated secretory phenotype (SASP) with the ability to impact on neighbouring cells |
| 19805069 | We show that cell surface-bound IL-1alpha is essential for signaling the senescence-associated secretion of IL-6 and IL-8, 2 proinflammatory cytokines that also reinforce the senescence growth arrest |
| 19650831 | This characteristic phenotype included persistently activated DNA damage signalling (detected as 53BP1/gammaH2AX(+) foci), enhanced senescence-associated beta-galactosidase activity, expansion of promyelocytic leukaemia nuclear compartments and induced expression of several cytokines (especially interleukins IL-6, IL-8 and IL-24), overall features shared by cells undergoing replicative or premature cellular senescence |
| 19584087 | We have identified a significantly altered cellular phenotype in response to chronic hypoxia as characterized by increased receptor-mediated apoptotic resistance, the induction of cellular senescence, increased invasion and the increased secretion of IL-1 beta, IL6, IL8 and TNFalpha cytokines |
| 19484468 | This analysis was used to compare cells from young and old populations, and after perturbing normal conditions, with changes in temperature, adenosine triphosphate (ATP) concentration (using NaF, an inhibitor of glycolysis, and alpha-toxin, a pore-forming molecule used to permeabilize red cells to ATP), and water transport rates [using glycerol, and p-chloromercuriphenylsulfonic acid (pCMBS) to inhibit aquaporins, AQPs] |
| 19407340 | Herein, we show that lithium induces a rapid and pronounced up-regulation of the matrix metalloproteinase (MMP)-1, an inflammation and senescent cell marker, at the mRNA and protein levels, whereas the induction of two other senescent cell markers is either weak (interleukin-8) or delayed (plasminogen activator inhibitor-1) |
| 19325234 | IL-6 and IL-8, two well-known proinflammatory cytokines, seem to play a central role in premature cellular senescence induction |
| 19298284 | The neutrophil chemoattractant interleukin (IL)-8 was low while the constitutive production of monocyte chemoattractant protein (MCP)-1 was highly elevated in medium from cultured CRL-7815 fibroblasts |
| 19053174 | In cultured premalignant epithelial cells, SASPs induced an epithelial-mesenchyme transition and invasiveness, hallmarks of malignancy, by a paracrine mechanism that depended largely on the SASP factors interleukin (IL)-6 and IL-8 |
| 19027816 | Resveratrol treatment effectively prevented increased production of intracellular reactive oxygen species (iROS) and inflammatory markers (IL1alpha, IL6, IL8, and ELAM-1), and reduced expression of the senescence markers sa-beta-gal, lipofuscin, and accumulation of carbonylated proteins |
| 18842679 | In this study, we compared the biological behavior of CAFs that were isolated from a prostate tumor to their normal-associated fibroblast (NAF) counterparts |
| 18838863 | While some of these factors have been previously shown to possess different pro-tumorigenic activities, we recently demonstrated that the secretion of CXCR2-binding chemokines (such as IL-8 or GROalpha) by senescent cells contribute to reinforce senescence via activation of the p53 pathway |
| 18555778 | Furthermore, we demonstrate that the transcription factor C/EBPbeta cooperates with IL-6 to amplify the activation of the inflammatory network, including IL-8 |
| 18555778 | In human colon adenomas, IL-8 specifically colocalized with arrested, p16(INK4A)-positive epithelium |
| 18313665 | TRAIL-stimulated production of several cytokines, IL-8, RANTES, MCP-1 and bFGF, and activation of caspases 1 and 8 was essential for this effect |
| 18313665 | Antibodies to IL-8, RANTES, and bFGF blocked TRAIL-induced cell proliferation and further stimulated apoptosis |
| 17955335 | DARC binds ELR + angiogenic chemokines such as IL-8 (CXCL8) |
| 17955335 | Moreover, addition of excess IL-8 during incubation had the similar effect |
| 16626901 | In particular, a significant upregulation of interleukin-8, VEGI, and the IGF-binding proteins 3 and 5 was observed |
| 16626901 | In the case of interleukin-8, a roughly 50-fold upregulation of the protein was also found in cellular supernatants |
| 16626901 | The extracellular proteins encoded by these genes are well known for their ability to modulate the apoptotic response of human cells, and in the case of interleukin-8, clear links to the establishment of atherosclerotic lesions have been defined |
| 16444871 | Exogenous ADMA also stimulated secretion of monocyte chemotactic protein-1 and interleukin-8 |
| 16161253 | We have previously reported that sodium fluoride (NaF) showed slightly higher cytotoxicity against human oral tumor cell lines than normal human oral cells |
| 16161253 | Possible changes in the NaF sensitivity of three normal human oral cell types (gingival fibroblast HGF, pulp cell HPC, periodontal ligament fibroblast HPLF) during in vitro ageing were investigated in the present study |
| 16161253 | NaF dose-dependently reduced the viable cell number, but did not show any beneficial (growth promoting) effect (so-called "hormesis") at lower concentrations |
| 16161253 | NaF produced large DNA fragments, without induction of internucleosomal DNA fragmentation, possibly due to weak activation of caspases -3, -8 and -9 |
| 16161253 | Higher concentrations of NaF were required to reduce the number of viable senescent cells than younger cells, indicating that cells become resistant to cytotoxicity of NaF with in vitro ageing |
| 15308550 | Exogenous ADMA also stimulated secretion of MCP-1 and interleukin-8 |
| 10811143 | The cAMP enhancers, caffeine, NaF, and forskolin significantly increased the thymulin-stimulated release of gonadotropins |
| 9892847 | The cAMP enhancers, caffeine, NaF and forskolin significantly increased the thymulin-stimulated release of GH while trifluoperazine, a protein kinase C inhibitor, had no effect |
| 9818729 | The cAMP enhancers, caffeine, NaF and forskolin, significantly increased the thymulin-stimulated release of PRL and TSH, while trifluoperazine, a protein kinase C inhibitor, had no effect |
| 9680181 | The activation of NF-kappaB has been recognized to regulate a number of genes necessary for normal T cell responses including IL-2, IL-6, IL-8, and several T cell surface receptors |
| 7737374 | On exposure to TNF, senescent HDF produced IL-6 and IL-8, but to a much lower degree than that produced by young HDF |
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