HCSGD entry for IL7R

1. General information

Official gene symbolIL7R
Entrez ID3575
Gene full nameinterleukin 7 receptor
Other gene symbolsCD127 CDW127 IL-7R-alpha IL7RA ILRA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000018Regulation of DNA recombinationTASbiological_process
GO:0000902Cell morphogenesisIEAbiological_process
GO:0001915Negative regulation of T cell mediated cytotoxicityIEAbiological_process
GO:0002377Immunoglobulin productionIEAbiological_process
GO:0003823Antigen bindingTASmolecular_function
GO:0004896Cytokine receptor activityIEAmolecular_function
GO:0004917Interleukin-7 receptor activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006955Immune responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007166Cell surface receptor signaling pathwayTASbiological_process
GO:0008361Regulation of cell sizeIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0010628Positive regulation of gene expressionIEAbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016049Cell growthIEAbiological_process
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0030217T cell differentiationIEAbiological_process
GO:0033089Positive regulation of T cell differentiation in thymusIEAbiological_process
GO:0038111Interleukin-7-mediated signaling pathwayTASbiological_process
GO:0042100B cell proliferationIEAbiological_process
GO:0048535Lymph node developmentIEAbiological_process
GO:0048872Homeostasis of number of cellsIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.10290779990.01034740320.66780971400.2004076527

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0710755208
GSE13712_SHEARUp1.4332850215
GSE13712_STATICUp0.7431944597
GSE19018Down-0.0398106038
GSE19899_A1Down-1.1181370887
GSE19899_A2Down-0.3972754278
PubMed_21979375_A1Down-1.2600601229
PubMed_21979375_A2Down-0.0400411266
GSE35957Down-0.0118066125
GSE36640Up0.6948746307
GSE54402Down-0.2826625634
GSE9593Down-1.2328370227
GSE43922Down-0.3286133864
GSE24585Up0.1316349588
GSE37065Up0.8614971115
GSE28863_A1Down-0.9325409274
GSE28863_A2Up0.1144355626
GSE28863_A3Down-0.8777650409
GSE28863_A4Up0.3748046551
GSE48662Up0.1026104923

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-26b-5pMIMAT0000083MIRT029787MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 5 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24499954Downregulation of CD127 after culture with IL-7 correlated inversely with CD4 T-cell counts and directly with Ki67 expression
24499954CD127 expression correlated inversely with proportions of CD4CD57 T cells, and pSTAT5 induction correlated inversely with CD4 T-cell expression of HLA-DR and CD57
22396780Instead a set of surface markers including IL-7Ralpha and KLRG1 is commonly used to predict the potential of CD8 effector T cells to differentiate into memory cells
21300823Although isolating human Tregs exhibiting low expression of CD127 markedly increases purity, the resulting Treg populations are still heterogeneous
21300823To examine the complexity of the Tregs defined by the CD127 phenotype in comparison with the previously described CD4(+)CD25(hi) subpopulations, we subdivided the CD25(hi) population of memory Tregs into subsets based on expression of CD127 and HLA-DR
18354208They exhibited increased expression of CD122 and CD127, akin to the Ag-independent T cell clonal expansions found in old specific pathogen-free laboratory mice
16365422By contrast, animals lacking only one of the MHC class I molecules (Kb or Db), or IL-7R, or devoid of T cell renewal via adult thymectomy, all exhibited significant increases in TCE incidence
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