HCSGD entry for IL5
1. General information
| Official gene symbol | IL5 |
|---|---|
| Entrez ID | 3567 |
| Gene full name | interleukin 5 (colony-stimulating factor, eosinophil) |
| Other gene symbols | EDF IL-5 TRF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0005125 | Cytokine activity | IEA | molecular_function |
| GO:0005137 | Interleukin-5 receptor binding | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | IDA IEA TAS | cellular_component |
| GO:0005615 | Extracellular space | TAS | cellular_component |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0006955 | Immune response | IEA | biological_process |
| GO:0008083 | Growth factor activity | IEA | molecular_function |
| GO:0019221 | Cytokine-mediated signaling pathway | IEA | biological_process |
| GO:0030890 | Positive regulation of B cell proliferation | IEA | biological_process |
| GO:0045645 | Positive regulation of eosinophil differentiation | IEA | biological_process |
| GO:0045893 | Positive regulation of transcription, DNA-templated | IEA | biological_process |
| GO:0046427 | Positive regulation of JAK-STAT cascade | IEA | biological_process |
| GO:0050731 | Positive regulation of peptidyl-tyrosine phosphorylation | ISS | biological_process |
| GO:0051024 | Positive regulation of immunoglobulin secretion | IEA | biological_process |
| GO:0051091 | Positive regulation of sequence-specific DNA binding transcription factor activity | IEA | biological_process |
| GO:0071803 | Positive regulation of podosome assembly | IDA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.8164682953 | 0.6470072946 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1563344525 |
| GSE13712_SHEAR | Down | -0.2828158516 |
| GSE13712_STATIC | Up | 0.0078325282 |
| GSE19018 | Down | -0.1192423139 |
| GSE19899_A1 | Down | -0.0940350461 |
| GSE19899_A2 | Up | 0.3999254069 |
| PubMed_21979375_A1 | Up | 0.2045393967 |
| PubMed_21979375_A2 | Down | -0.2168721980 |
| GSE35957 | Down | -0.0527358942 |
| GSE36640 | Down | -0.0223460708 |
| GSE54402 | Down | -0.0172026719 |
| GSE9593 | Down | -0.0056358916 |
| GSE43922 | Up | 0.0138019784 |
| GSE24585 | Up | 0.1600054757 |
| GSE37065 | Up | 0.0078859836 |
| GSE28863_A1 | Down | -0.2563499904 |
| GSE28863_A2 | Up | 0.0336015694 |
| GSE28863_A3 | Up | 0.0436188563 |
| GSE28863_A4 | Up | 0.0387380442 |
| GSE48662 | Up | 0.0489218857 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017691 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-454-5p | MIMAT0003884 | MIRT039253 | CLASH | Functional MTI (Weak) | 23622248 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.
