HCSGD entry for IL4R

1. General information

Official gene symbolIL4R
Entrez ID3566
Gene full nameinterleukin 4 receptor
Other gene symbolsCD124 IL-4RA IL4RA
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002532Production of molecular mediator involved in inflammatory responseIEAbiological_process
GO:0004896Cytokine receptor activityIEAmolecular_function
GO:0004913Interleukin-4 receptor activityTASmolecular_function
GO:0005057Receptor signaling protein activityTASmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006955Immune responseTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019221Cytokine-mediated signaling pathwayTASbiological_process
GO:0030728OvulationIEAbiological_process
GO:0035556Intracellular signal transductionTASbiological_process
GO:0035771Interleukin-4-mediated signaling pathwayTASbiological_process
GO:0042127Regulation of cell proliferationIEAbiological_process
GO:0042832Defense response to protozoanIEAbiological_process
GO:0043032Positive regulation of macrophage activationIEAbiological_process
GO:0043235Receptor complexIDAcellular_component
GO:0043560Insulin receptor substrate bindingRCAmolecular_function
GO:0043627Response to estrogenIEAbiological_process
GO:0045626Negative regulation of T-helper 1 cell differentiationIEAbiological_process
GO:0045630Positive regulation of T-helper 2 cell differentiationIEAbiological_process
GO:0090197Positive regulation of chemokine secretionIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00942081610.81586695790.24860190381.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0006065278
GSE13712_SHEARUp0.0091431781
GSE13712_STATICUp0.1689110229
GSE19018Down-0.2024913131
GSE19899_A1Up0.5329658599
GSE19899_A2Up1.8131998627
PubMed_21979375_A1Up2.1130440168
PubMed_21979375_A2Up3.5512786753
GSE35957Down-0.7169805843
GSE36640Up0.4151258617
GSE54402Down-0.1273956872
GSE9593Down-0.2431442163
GSE43922Up1.3695319289
GSE24585Down-0.1319010959
GSE37065Up0.0914314062
GSE28863_A1Up0.0537300029
GSE28863_A2Up0.1980794339
GSE28863_A3Up0.0778121486
GSE28863_A4Up0.0979724338
GSE48662Up0.1261948421

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

AER001DB05078 -

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-331-3pMIMAT0000760MIRT043562CLASHFunctional MTI (Weak)23622248
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: This gene isn't in text-mining gene-sentence result.