HCSGD entry for FASLG

1. General information

Official gene symbolFASLG
Entrez ID356
Gene full nameFas ligand (TNF superfamily, member 6)
Other gene symbolsALPS1B APT1LG1 APTL CD178 CD95-L CD95L FASL TNFSF6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000122Negative regulation of transcription from RNA polymerase II promoterIDAbiological_process
GO:0005102Receptor bindingTASmolecular_function
GO:0005125Cytokine activityIEAmolecular_function
GO:0005164Tumor necrosis factor receptor bindingIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionTAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0005901CaveolaIEAcellular_component
GO:0006351Transcription, DNA-templatedIEAbiological_process
GO:0006915Apoptotic processTASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processIGI IMP TASbiological_process
GO:0006925Inflammatory cell apoptotic processIEAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007267Cell-cell signalingTASbiological_process
GO:0008284Positive regulation of cell proliferationIEAbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIDAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0016525Negative regulation of angiogenesisIDAbiological_process
GO:0030644Cellular chloride ion homeostasisIEAbiological_process
GO:0032496Response to lipopolysaccharideIEAbiological_process
GO:0043065Positive regulation of apoptotic processIDAbiological_process
GO:0043123Positive regulation of I-kappaB kinase/NF-kappaB signalingIEPbiological_process
GO:0043202Lysosomal lumenIEAcellular_component
GO:0043525Positive regulation of neuron apoptotic processIEAbiological_process
GO:0045742Positive regulation of epidermal growth factor receptor signaling pathwayIEAbiological_process
GO:0046666Retinal cell programmed cell deathIEAbiological_process
GO:0048388Endosomal lumen acidificationIEAbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0060205Cytoplasmic membrane-bounded vesicle lumenIEAcellular_component
GO:0070062Extracellular vesicular exosomeIDAcellular_component
GO:0070231T cell apoptotic processIDAbiological_process
GO:0070265Necrotic cell deathIDAbiological_process
GO:0070266Necroptotic processIDAbiological_process
GO:0070848Response to growth factorIEAbiological_process
GO:0097190Apoptotic signaling pathwayIDA TASbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIDAbiological_process
GO:0097527Necroptotic signaling pathwayIDAbiological_process
GO:2000353Positive regulation of endothelial cell apoptotic processIDAbiological_process
GO:2001239Regulation of extrinsic apoptotic signaling pathway in absence of ligandTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.75430428180.79867025190.99999024731.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Down-0.0358370461
GSE13712_SHEARDown-0.1991987364
GSE13712_STATICDown-0.0027877240
GSE19018Up0.0914220564
GSE19899_A1Up0.0005871478
GSE19899_A2Up0.1030260509
PubMed_21979375_A1Up0.1169225993
PubMed_21979375_A2Down-0.1039864364
GSE35957Down-0.1116891849
GSE36640Up0.0613436767
GSE54402Down-0.0190136252
GSE9593Down-0.0865315049
GSE43922Up0.1624375143
GSE24585Down-0.0682011634
GSE37065Up0.0164303446
GSE28863_A1Down-0.0270571836
GSE28863_A2Up0.0035255705
GSE28863_A3Up0.2824054677
GSE28863_A4Up0.1810882498
GSE48662Down-0.0166070969

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-21-5pMIMAT0000076MIRT006989Luciferase reporter assay//Western blotFunctional MTI21820586
hsa-miR-21-5pMIMAT0000076MIRT006989Luciferase reporter assay//qRT-PCR//Western blotFunctional MTI23177026
hsa-miR-21-5pMIMAT0000076MIRT006989Reporter assay;Western blot;OtherFunctional MTI20371612
hsa-miR-26b-5pMIMAT0000083MIRT029780MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25448133Fas-ligand was analysed since it functions in both apoptosis and inflammation
25448133Serum miR-21 and miR-146a levels and FasL concentrations were lower in HRT users compared to their non-using co-twins, demonstrating their responsiveness to HRT
25448133Based on the pairwise FasL analysis, FasL concentration is likely to be genetically controlled
15882354In addition, CD28(null) memory CD8(+) T cells expressed several natural killer cell receptors and high levels of granzymes, perforin, and FasL, indicating an increasing capacity for cytotoxicity during memory CD8(+) T-cell aging
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