HCSGD entry for FAS

1. General information

Official gene symbolFAS
Entrez ID355
Gene full nameFas cell surface death receptor
Other gene symbolsALPS1A APO-1 APT1 CD95 FAS1 FASTM TNFRSF6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0002377Immunoglobulin productionIEAbiological_process
GO:0003014Renal system processIEAbiological_process
GO:0004871Signal transducer activityTASmolecular_function
GO:0004872Receptor activityNASmolecular_function
GO:0004888Transmembrane signaling receptor activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005576Extracellular regionIEAcellular_component
GO:0005634NucleusIDAcellular_component
GO:0005737CytoplasmIDAcellular_component
GO:0005829CytosolNAScellular_component
GO:0005886Plasma membraneIDA IMP TAScellular_component
GO:0006461Protein complex assemblyTASbiological_process
GO:0006915Apoptotic processIDA IEA TASbiological_process
GO:0006919Activation of cysteine-type endopeptidase activity involved in apoptotic processTASbiological_process
GO:0006924Activation-induced cell death of T cellsIEAbiological_process
GO:0006925Inflammatory cell apoptotic processIEAbiological_process
GO:0006927Transformed cell apoptotic processIEAbiological_process
GO:0006955Immune responseIEAbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0008625Extrinsic apoptotic signaling pathway via death domain receptorsIEAbiological_process
GO:0009636Response to toxic substanceIEAbiological_process
GO:0009897External side of plasma membraneIEAcellular_component
GO:0009986Cell surfaceIDAcellular_component
GO:0010467Gene expressionIEAbiological_process
GO:0010940Positive regulation of necrotic cell deathIMPbiological_process
GO:0016020MembraneIEAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0019724B cell mediated immunityIEAbiological_process
GO:0019900Kinase bindingIPImolecular_function
GO:0031264Death-inducing signaling complexIDAcellular_component
GO:0031265CD95 death-inducing signaling complexIDAcellular_component
GO:0032464Positive regulation of protein homooligomerizationIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0042981Regulation of apoptotic processNASbiological_process
GO:0043065Positive regulation of apoptotic processIDA IMPbiological_process
GO:0043066Negative regulation of apoptotic processIEAbiological_process
GO:0045060Negative thymic T cell selectionIEAbiological_process
GO:0045121Membrane raftIDAcellular_component
GO:0045619Regulation of lymphocyte differentiationIEAbiological_process
GO:0045637Regulation of myeloid cell differentiationIEAbiological_process
GO:0048536Spleen developmentIEAbiological_process
GO:0050869Negative regulation of B cell activationIEAbiological_process
GO:0051260Protein homooligomerizationIEAbiological_process
GO:0051384Response to glucocorticoidIEAbiological_process
GO:0071260Cellular response to mechanical stimulusIEPbiological_process
GO:0071285Cellular response to lithium ionIEAbiological_process
GO:0071455Cellular response to hyperoxiaIMPbiological_process
GO:0097049Motor neuron apoptotic processIEAbiological_process
GO:0097190Apoptotic signaling pathwayTASbiological_process
GO:0097191Extrinsic apoptotic signaling pathwayIMPbiological_process
GO:0097192Extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
GO:2001239Regulation of extrinsic apoptotic signaling pathway in absence of ligandTASbiological_process
GO:2001241Positive regulation of extrinsic apoptotic signaling pathway in absence of ligandIEAbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.01494327340.66083869910.30395819171.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4308773583
GSE13712_SHEARUp1.5372149368
GSE13712_STATICUp1.5639236550
GSE19018Up0.0747281279
GSE19899_A1Down-0.2723098051
GSE19899_A2Down-0.1596793079
PubMed_21979375_A1Up0.2154736373
PubMed_21979375_A2Up0.7551270665
GSE35957Down-0.1215075076
GSE36640Up1.4614163744
GSE54402Down-1.2346394635
GSE9593Up0.4294630271
GSE43922Up0.2384902775
GSE24585Down-0.0162241783
GSE37065Up0.5722434981
GSE28863_A1Up0.1660923422
GSE28863_A2Down-0.0907173187
GSE28863_A3Down-0.5533708869
GSE28863_A4Up0.2458785367
GSE48662Down-0.0790977177

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-106a-5pMIMAT0000103MIRT006331Luciferase reporter assayFunctional MTI22431000
hsa-miR-21-5pMIMAT0000076MIRT002421MicroarrayFunctional MTI (Weak)20048743
hsa-miR-146a-5pMIMAT0000449MIRT005581Luciferase reporter assay//Western blotFunctional MTI20656888
hsa-miR-504-5pMIMAT0002875MIRT016252qRT-PCRFunctional MTI (Weak)20542001
hsa-miR-98-5pMIMAT0000096MIRT027598MicroarrayFunctional MTI (Weak)19088304
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    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 6 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

25392765The CD8 T cell phenotype was defined by the surface expression of CD28 and CD95
22613541The frequency of CD28 and CD95 demonstrated a "curved" rather than linear tendency by age
20137575Altered CD28 and CD95 mRNA expression in peripheral blood mononuclear cells from elderly patients with primary non-small cell lung cancer
20137575BACKGROUND: The expression of the co-stimulatory molecule CD28 and death receptor CD95 on T cells, which change with age, are considered as important immunological parameters of immunosenescence
20137575It is well established that CD28 and CD95 are associated with tumorgenesis and tumor progression, but the relationship between the age-related changes of these two immunological markers and cancer in the elderly is largely unknown
20137575METHODS: The levels of CD28 and CD95 mRNA in peripheral blood mononuclear cells (PBMCs) from sixty-three elderly patients (aged > or = 60 years) with primary non-small cell lung cancer (NSCLC) were analyzed by real-time fluorescence-based quantitative polymerase chain reaction (FQ-PCR)
20137575RESULTS: CD28 mRNA levels were significantly lower and CD95 mRNA levels were significantly higher in elderly patients with NSCLC than in the other groups
20137575By Logistic regression analysis an increased risk of NSCLC was markedly associated with aging, down-regulation of CD28 mRNA and up-regulation of CD95 mRNA, and CD28 mRNA had an obvious negative correlation with the CD95 mRNA
20137575In addition, the mRNA levels of CD28 and CD95 in the peripheral blood of the elderly patients was closely associated with the tumor node metastasis (TNM) stages, grade of cell differentiation and lymph node metastasis status, but not related to pathological types
20137575CONCLUSIONS: The results suggest a close relationship between T cell senescence and NSCLC tumour progress in the elderly, and that up-regulation of CD28 mRNA or down-regulation of CD95 mRNA in peripheral blood T cells may play an important role in inhibiting oncogenesis and development of primary NSCLC in the elderly
16951143In this study, we used chromatin immunoprecipitation to determine that p53 preferentially occupied the promoters of growth arrest genes p21 and GADD45 in senescent normal human diploid fibroblasts but not the promoters of other target genes that recruited p53 following doxorubicin-induced DNA damage, such as apoptosis regulators TNFRSF10b, TNFRSF6, and PUMA
15130673Cell death following stimulations: (i) corresponded to apoptosis, associated with necrosis at the end of the culture; (ii) was not, for its main part, mediated through CD95/CD178 or TNFRII/TNF alpha interactions; and (iii) occurred in spite of bcl-2 increased expression
8688670Regulation of CD95 (APO-1) expression and the induction of apoptosis in human T cells: changes in old age
8688670CD95 (APO-1) is a member of the TNF/nerve growth factor receptor superfamily, which is expressed on the surface of different types of cells
8688670Cross-linking of CD95 leads to the induction of apoptosis
8688670In view of the known decline of immune function in old age it seemed of interest to study the expression and inducibility of CD95 in peripheral blood T lymphocytes from young and old healthy subjects selected according to the guidelines laid down in the Senieur protocol of the European Community's Concerted Action Programme on Aging
8688670Resting T cells did not express CD95
8688670The activation-induced increase in CD95 expression was followed by a decrease, which was observed in both age groups, but was less pronounced in old subjects
8688670Under long-term culture conditions T cell lines derived from both young and old individuals progressively lost the capacity to decrease the expression of CD95 at the end of their activation cycle and an increasing susceptibility to activation-driven programmed cell death was noted
8688670The results suggest that a lowered sensitivity in the regulation of CD95 as well as an increased susceptibility to apoptosis-inducing mechanisms during clonal expansion are features of T cell senescence
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