HCSGD entry for KLK3
1. General information
| Official gene symbol | KLK3 |
|---|---|
| Entrez ID | 354 |
| Gene full name | kallikrein-related peptidase 3 |
| Other gene symbols | APS KLK2A1 PSA hK3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0004252 | Serine-type endopeptidase activity | IEA | molecular_function |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005576 | Extracellular region | NAS TAS | cellular_component |
| GO:0006508 | Proteolysis | IEA | biological_process |
| GO:0008236 | Serine-type peptidase activity | TAS | molecular_function |
| GO:0016525 | Negative regulation of angiogenesis | NAS | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5934552069 | 0.8936116257 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0440054552 |
| GSE13712_SHEAR | Up | 0.0095645465 |
| GSE13712_STATIC | Up | 0.1682972079 |
| GSE19018 | Up | 0.1262779349 |
| GSE19899_A1 | Up | 0.0456853497 |
| GSE19899_A2 | Up | 0.0925988276 |
| PubMed_21979375_A1 | Up | 0.1277259731 |
| PubMed_21979375_A2 | Down | -0.0202904690 |
| GSE35957 | Up | 0.0310762710 |
| GSE36640 | Up | 0.1893322125 |
| GSE54402 | Up | 0.1675149817 |
| GSE9593 | Down | -0.0689540795 |
| GSE43922 | Up | 0.0518043266 |
| GSE24585 | Down | -0.0772807817 |
| GSE37065 | Down | -0.0199975805 |
| GSE28863_A1 | Down | -0.0457698556 |
| GSE28863_A2 | Down | -0.0115110743 |
| GSE28863_A3 | Up | 0.1890307956 |
| GSE28863_A4 | Up | 0.1176710858 |
| GSE48662 | Down | -0.1005625775 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017222 | Microarray | Functional MTI (Weak) | 18185580 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 3 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25203674 | This suggests decreased DNA binding of the AR, which is further indicated by an impaired chromatin recruitment of the AR to the prostate-specific antigen promoter and enhancer shown by chromatin immunoprecipitation experiments |
| 20826091 | Further, the expression of the prostate specific antigen used as a diagnostic marker is also repressed |
| 14580871 | Cells stained positive for cytokeratins 8/18, but did not express other lumenal markers, such as prostate-specific antigen and androgen-receptors |
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