HCSGD entry for NMNAT3
1. General information
| Official gene symbol | NMNAT3 |
|---|---|
| Entrez ID | 349565 |
| Gene full name | nicotinamide nucleotide adenylyltransferase 3 |
| Other gene symbols | PNAT-3 PNAT3 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0000309 | Nicotinamide-nucleotide adenylyltransferase activity | IEA TAS | molecular_function |
| GO:0004515 | Nicotinate-nucleotide adenylyltransferase activity | IDA | molecular_function |
| GO:0005524 | ATP binding | IEA | molecular_function |
| GO:0005739 | Mitochondrion | IDA IEA | cellular_component |
| GO:0005829 | Cytosol | TAS | cellular_component |
| GO:0006766 | Vitamin metabolic process | TAS | biological_process |
| GO:0006767 | Water-soluble vitamin metabolic process | TAS | biological_process |
| GO:0009435 | NAD biosynthetic process | IC IEA | biological_process |
| GO:0009611 | Response to wounding | IEA | biological_process |
| GO:0016779 | Nucleotidyltransferase activity | IEA | molecular_function |
| GO:0019674 | NAD metabolic process | TAS | biological_process |
| GO:0044281 | Small molecule metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.9094207211 | 0.6175420045 | 0.9999902473 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.1484713346 |
| GSE13712_SHEAR | Down | -0.4610685601 |
| GSE13712_STATIC | Down | -0.0882562409 |
| GSE19018 | Up | 0.0784975106 |
| GSE19899_A1 | Down | -0.1442111806 |
| GSE19899_A2 | Up | 0.1957985144 |
| PubMed_21979375_A1 | Up | 0.0962066114 |
| PubMed_21979375_A2 | Down | -0.1316929789 |
| GSE35957 | Down | -0.0337834156 |
| GSE36640 | Down | -0.1201184969 |
| GSE54402 | Down | -0.0256747096 |
| GSE9593 | Down | -0.0939549180 |
| GSE43922 | Up | 0.0242141093 |
| GSE24585 | Down | -0.0395202506 |
| GSE37065 | Up | 0.1517702571 |
| GSE28863_A1 | - | - |
| GSE28863_A2 | - | - |
| GSE28863_A3 | - | - |
| GSE28863_A4 | - | - |
| GSE48662 | Up | 0.0239592484 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Alpha,Beta-Methyleneadenosine-5'-Triphosphate | DB02596 | EXPT00539 |
| Nicotinamide Mononucleotide | DB03227 | EXPT02366 |
| Deamido-Nad+ | DB04099 | EXPT01234 |
- MicroRNAs
- mirTarBase
No target information from mirTarBase
- mirTarBase
- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 20457531 | In humans, three isozymes have been identified: NMNAT1, which is widely expressed in all tissues, NMNAT2 and NMNAT3, which show a tissue-specific expression and whose mRNA levels are generally lower compared to NMNAT1 |
| 20457531 | RBC represent the first human cell type with a remarkable predominance of NMNAT3, and this unique expression pattern is discussed in light of the catalytic properties of the isozymes and in consideration of the biochemical microenvironment of RBC |
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