HCSGD entry for IGFBP7
1. General information
| Official gene symbol | IGFBP7 |
|---|---|
| Entrez ID | 3490 |
| Gene full name | insulin-like growth factor binding protein 7 |
| Other gene symbols | AGM FSTL2 IBP-7 IGFBP-7 IGFBP-7v IGFBPRP1 MAC25 PSF RAMSVPS TAF |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001558 | Regulation of cell growth | IEA | biological_process |
| GO:0005515 | Protein binding | IPI | molecular_function |
| GO:0005520 | Insulin-like growth factor binding | IEA | molecular_function |
| GO:0005615 | Extracellular space | IDA | cellular_component |
| GO:0007155 | Cell adhesion | IDA | biological_process |
| GO:0007566 | Embryo implantation | IEA | biological_process |
| GO:0008285 | Negative regulation of cell proliferation | TAS | biological_process |
| GO:0009408 | Response to heat | IEA | biological_process |
| GO:0031012 | Extracellular matrix | IDA | cellular_component |
| GO:0032526 | Response to retinoic acid | IEA | biological_process |
| GO:0032870 | Cellular response to hormone stimulus | IEA | biological_process |
| GO:0048839 | Inner ear development | IEA | biological_process |
| GO:0050810 | Regulation of steroid biosynthetic process | IEA | biological_process |
| GO:0051414 | Response to cortisol | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.6434140344 | 0.0346994491 | 0.9999902473 | 0.3527386898 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.3948380778 |
| GSE13712_SHEAR | Up | 0.1650553725 |
| GSE13712_STATIC | Up | 0.0481225453 |
| GSE19018 | Up | 0.3790261957 |
| GSE19899_A1 | Down | -0.1727114563 |
| GSE19899_A2 | Down | -0.2753290351 |
| PubMed_21979375_A1 | Down | -1.0693918779 |
| PubMed_21979375_A2 | Down | -0.5369632466 |
| GSE35957 | Up | 0.1694441742 |
| GSE36640 | Up | 1.4069017043 |
| GSE54402 | Down | -0.4278992722 |
| GSE9593 | Up | 0.2395956792 |
| GSE43922 | Down | -0.5214209500 |
| GSE24585 | Down | -0.0609726759 |
| GSE37065 | Up | 0.3850260346 |
| GSE28863_A1 | Down | -0.9914403628 |
| GSE28863_A2 | Down | -0.0109823018 |
| GSE28863_A3 | Up | 0.0636272100 |
| GSE28863_A4 | Down | -0.0317484143 |
| GSE48662 | Down | -0.0273591017 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Name | Drug | Accession number |
|---|---|---|
| Insulin Pork | DB00071 | BTD00031 | BIOD00031 |
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-124-3p | MIMAT0000422 | MIRT022719 | Proteomics;Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-1 | MIMAT0000416 | MIRT023758 | Proteomics | Functional MTI (Weak) | 18668040 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 25466460 | Sensitive and selective analysis of a wide concentration range of IGFBP7 using a surface plasmon resonance biosensor |
| 25466460 | A sensitive method for selectively detecting insulin-like growth factor-binding protein 7 (IGFBP7) over a wide range of concentrations based on the surface plasmon resonance (SPR) biosensing techniques is described |
| 25466460 | IGFBP7 has been shown to regulate cell proliferation, cell adhesion, cellular senescence, apoptosis, and angiogenesis in several different cancer cell lines |
| 25466460 | Since the concentration of IGFBP7 can vary widely in the body, determining the precise concentration of IGFBP7 over a wide range of concentrations is important, since it serves as an inducible biomarker for both disease diagnosis and subsequent therapy |
| 25466460 | The SPR sensing method is based on the selective interaction of IGFBP7 with specific anti-IGFBP7 proteins on a gold thin film, which was covalently bound to the Fc-binding domain of protein G on a mixed self-assembled monolayer composed of DSNHS (S2(CH2)11COO(CH2)2COO-(N-hydroxysuccinimide)) and mercaptoundecanol, and effect of this on changes in the SPR profiles |
| 25466460 | The SPR biosensor also shows specificity for IGFBP7 compared to that for biologically relevant interleukin (IL) derivatives including IL4, IL23, IL29, and IFG1 |
| 25466460 | These molecules are also present along with IGFBP7 in the cell culture medium and have the potential to interfere with the analysis |
| 25466460 | Finally, the level secretion of IGFBP7 from cancer cells detected by the SPR biosensor showed a good correlation with a commercial kit using an IGFBP7 enzyme-linked immunosorbent assay |
| 25466460 | The findings reported herein indicate that the SPR biosensor for IGFBP7 would be applicable in a wide variety of biomedical fields |
| 24201810 | To delineate a hallmark of stem cells SASP, we have characterized the factors secreted by senescent MSC identifying insulin-like growth factor binding proteins 4 and 7 (IGFBP4 and IGFBP7) as key components needed for triggering senescence in young MSC |
| 24201810 | The pro-senescent effects of IGFBP4 and IGFBP7 are reversed by single or simultaneous immunodepletion of either proteins from senescent-CM |
| 22363855 | Redundant, secondary senescence systems are also present and include the p14-p53-p21 pathway, the IGFBP7 pathway, the FBXO31 pathway, and the PI3K mediated stress induced endoplasmic reticulum unfolded protein response |
| 21795858 | Insulin-like growth factor binding protein 7 exhibits tumor suppressive and vessel stabilization properties in U87MG and T98G glioblastoma cell lines |
| 21795858 | Insulin-like growth factor binding protein 7 (IGFBP7) is downregulated in several solid cancers |
| 21795858 | IGFBP7 has been proposed to act as a tumor suppressor gene through mechanisms involving senescence and apoptotic pathways |
| 21795858 | The tumor suppressor effect of IGFBP7 in glioblastoma multiforme (GBM) was examined in this study using two human GBM cell lines, U87MG and T98G |
| 21795858 | Exogenously applied IGFBP7 (20 and 100 nM) significantly reduced U87MG (~70 and ~75%, respectively) and T98G (~37 and ~50%, respectively) cell growth in soft agar |
| 21795858 | The inhibitory effect of IGFBP7 on U87MG cell growth was further assessed in vivo using U87MG cells grafted on the chick chorioallantoic membrane |
| 21795858 | In this model, U87MG cells formed solid and highly vascularized tumors that were reduced in size (~40%) when treated with 500 nM IGFBP7 compared with control tumors |
| 21795858 | IGFBP7 induced both aortic smooth muscle cell (AoSMC) chemoattraction and endothelial cell (EC) transdifferentiation into a SM-like cell phenotype |
| 21795858 | U87MG conditioned media-induced IGFBP7 expression in ECs was significantly inhibited by the cross-talk/interaction with SMCs |
| 21795858 | This study indicates that IGFBP7 suppresses U87MG tumor cell growth, induces cell senescence and participates in tumor vessel stabilization by promoting SMC/pericyte recruitment and differentiation |
| 21047732 | In DAOY cells, senescence-associated secretory factors, such as interleukin-6 and insulin-like growth factor binding protein 7, were strongly upregulated after OTX2 induction |
| 20464481 | Previously, we have shown that insulin-like growth factor binding protein-7 (IGFBP-7) expression is inversely correlated with disease progression in breast cancer and is associated with poor outcome |
| 20464481 | To further investigate the role of IGFBP-7 in the growth and metastatic behavior of breast cancer, primary breast tumors and metastatic tumors derived from the same patients were analyzed for IGFBP-7 expression |
| 20464481 | Immunohistochemical analysis revealed that IGFBP-7 is downregulated in half of the human metastatic breast tumors tested |
| 20464481 | IGFBP-7 has been linked to suppression of oncogenic pathways and can directly restore cellular senescence in melanomas, leading to their regression |
| 20464481 | Expression of IGFBP-7 was downregulated upon each serial implantation |
| 20464481 | To investigate the role of IGFBP-7 in breast tumor suppression, IGFBP-7 was overexpressed in the triple negative MDA-MB-468 human breast cancer line by stable transfection of a pSec-tag2-IGFBP-7 vector |
| 20464481 | The parental MDA-MB-468 breast cancer cells expressed extremely low levels of endogenous IGFBP-7 |
| 20464481 | The production of IGFBP-7 protein by the MDA-MB-468 cells stably transfected with IGFBP-7 was confirmed by immunoblotting with anti-IGFBP-7 antibody |
| 20464481 | Ectopic overexpression of IGFBP-7 significantly reduced the growth of the IGFBP-7 transfected MDA-MB-468 cells compared to the parental MDA-MB-468 cells |
| 20464481 | IGFBP-7 strongly suppressed the phosphorylation of the mitogen-activated protein kinases (MAPK) ERK-1/2, suggesting that IGFBP-7 mediates its anti-proliferative effects through negative feedback signaling |
| 20464481 | When injected subcutaneously into NOD/SCID mice, the increased expression of IGFBP-7 in the MDA-MB-468 transfected cells reduced the rate of tumor growth in comparison to the parental MDA-MB-468 controls |
| 20464481 | These results suggest that the growth of breast cancer could be prevented by the forced expression of IGFBP-7 protein |
| 20027224 | Furthermore, we identified CIMP-dependent DNA hypermethylation of IGFBP7, which has been shown to mediate BRAF(V600E)-induced cellular senescence and apoptosis |
| 20027224 | Promoter DNA hypermethylation of IGFBP7 was associated with silencing of the gene |
| 20027224 | CIMP-specific inactivation of BRAF(V600E)-induced senescence and apoptosis pathways by IGFBP7 DNA hypermethylation might create a favorable context for the acquisition of BRAF(V600E) in CIMP+ colorectal cancer |
| 18838863 | Importantly, our data adds to that presented by several groups suggesting that also other factors secreted during senescence (such as PAI-1, IGFBP-7 or IL-6) contribute to the senescent response |
| 18267066 | In addition, IGFBP7 triggers apoptosis in cells that have progressed to melanoma, suggesting a new approach for melanoma treatment |
| 17451653 | Overexpression of IGFBP3 or IGFBPrP1 in the immortal LFS cell lines suppressed cell growth and inhibited colony formation |
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