HCSGD entry for IGFBP6

1. General information

Official gene symbolIGFBP6
Entrez ID3489
Gene full nameinsulin-like growth factor binding protein 6
Other gene symbolsIBP6
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001558Regulation of cell growthIEAbiological_process
GO:0005520Insulin-like growth factor bindingIEAmolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0007165Signal transductionNASbiological_process
GO:0008285Negative regulation of cell proliferationTASbiological_process
GO:0031994Insulin-like growth factor I bindingIEAmolecular_function
GO:0044267Cellular protein metabolic processTASbiological_process
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.19290597240.02701559970.85202086900.3138491615

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.8764760253
GSE13712_SHEARUp0.8367099889
GSE13712_STATICUp1.0779809423
GSE19018Up0.3391071536
GSE19899_A1Down-1.7344770475
GSE19899_A2Down-1.4345014472
PubMed_21979375_A1Down-1.0276301974
PubMed_21979375_A2Down-1.2751753049
GSE35957Down-0.7123418839
GSE36640Down-0.2067917870
GSE54402Down-1.4503793196
GSE9593Up0.2420660540
GSE43922--
GSE24585--
GSE37065--
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.2483677850

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Not regulated by drugs

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

21820463Among these was insulin-like growth factor binding protein-6 (IGFBP-6), which was chosen for further analysis
21820463When IGFBP-6 gene expression was downregulated, cell proliferation was inhibited and apoptotic cell death was increased
21820463Furthermore, downregulation of IGFBP-6 led to premature entry into cellular senescence
21820463Since IGFBP-6 overexpression increased cellular lifespan, the data suggest that IGFBP-6, in contrast to other IGF binding proteins, is a negative regulator of cellular senescence in human fibroblasts
15958393Insulin-like growth factor-binding protein-6 (IGFBP-6) consistently showed up in the conditioned medium of H2O2-treated cells but not from untreated cells
15958393Increased IGFBP-6 production due to H2O2 treatment was confirmed by RT-PCR and Western blot analyses
15958393While H2O2 induced a dose-dependent elevation of IGFBP-6 mRNA, Western blot analyses detected elevated levels of IGFBP-6 protein in the conditioned medium of H2O2-treated cells
15958393Using several types of toxins at sublethal doses, including cis-platin, hydroxyurea, colchicine, L-mimosine, rhodamine, dithiothreitol, or N-ethylmaleimide, we found that these agents induced increases of IGFBP-6 at mRNA and protein levels
15958393An increased level of IGFBP-6 protein was detected in the plasma of aging mice and of young mice treated with doxorubicin
15958393These data suggest that IGFBP-6 may serve as a sensitive biomarker of cell degeneration or injury in vitro and in vivo
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