HCSGD entry for IGFBP4
1. General information
| Official gene symbol | IGFBP4 |
|---|---|
| Entrez ID | 3487 |
| Gene full name | insulin-like growth factor binding protein 4 |
| Other gene symbols | BP-4 HT29-IGFBP IBP4 IGFBP-4 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001501 | Skeletal system development | TAS | biological_process |
| GO:0001558 | Regulation of cell growth | IEA | biological_process |
| GO:0005520 | Insulin-like growth factor binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006259 | DNA metabolic process | TAS | biological_process |
| GO:0006954 | Inflammatory response | IEA | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008283 | Cell proliferation | TAS | biological_process |
| GO:0010906 | Regulation of glucose metabolic process | IEA | biological_process |
| GO:0043410 | Positive regulation of MAPK cascade | IEA | biological_process |
| GO:0043568 | Positive regulation of insulin-like growth factor receptor signaling pathway | IEA | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
| GO:0044342 | Type B pancreatic cell proliferation | IEA | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.5502905285 | 0.0522583944 | 0.9999902473 | 0.4301104440 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Down | -0.0556430015 |
| GSE13712_SHEAR | Down | -0.9186692044 |
| GSE13712_STATIC | Down | -1.1122680534 |
| GSE19018 | Down | -0.1039929223 |
| GSE19899_A1 | Down | -0.3395966782 |
| GSE19899_A2 | Down | -0.0230354937 |
| PubMed_21979375_A1 | Down | -0.6057852240 |
| PubMed_21979375_A2 | Down | -0.4423694357 |
| GSE35957 | Up | 0.0469572875 |
| GSE36640 | Up | 0.4424534896 |
| GSE54402 | Down | -0.8757401489 |
| GSE9593 | Down | -0.0952660228 |
| GSE43922 | Down | -0.1391905118 |
| GSE24585 | Up | 0.0966674458 |
| GSE37065 | Up | 0.1592288093 |
| GSE28863_A1 | Up | 0.1080731791 |
| GSE28863_A2 | Up | 0.5752614481 |
| GSE28863_A3 | Up | 0.2286687465 |
| GSE28863_A4 | Down | -0.0290518809 |
| GSE48662 | Up | 0.5134982618 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-335-5p | MIMAT0000765 | MIRT017871 | Microarray | Functional MTI (Weak) | 18185580 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022691 | Microarray | Functional MTI (Weak) | 18668037 |
| hsa-miR-7-5p | MIMAT0000252 | MIRT025735 | Microarray | Functional MTI (Weak) | 19073608 |
| hsa-miR-26b-5p | MIMAT0000083 | MIRT029547 | Microarray | Functional MTI (Weak) | 19088304 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 24201810 | To delineate a hallmark of stem cells SASP, we have characterized the factors secreted by senescent MSC identifying insulin-like growth factor binding proteins 4 and 7 (IGFBP4 and IGFBP7) as key components needed for triggering senescence in young MSC |
| 24201810 | The pro-senescent effects of IGFBP4 and IGFBP7 are reversed by single or simultaneous immunodepletion of either proteins from senescent-CM |
| 24201810 | The blocking of IGFBP4/7 also reduces apoptosis and promotes cell growth, suggesting that they may have a pleiotropic effect on MSC biology |
| 7517406 | IGFBP-4 was degraded by a protease that appeared to be different from the protease(s) involved in degradation of the other IGFBPs |
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