HCSGD entry for IGFBP1
1. General information
| Official gene symbol | IGFBP1 |
|---|---|
| Entrez ID | 3484 |
| Gene full name | insulin-like growth factor binding protein 1 |
| Other gene symbols | AFBP IBP1 IGF-BP25 PP12 hIGFBP-1 |
| Links to Entrez Gene | Links to Entrez Gene |
2. Neighbors in the network
This gene isn't in PPI subnetwork.
3. Gene ontology annotation
GO ID | GO term | Evidence | Category |
|---|---|---|---|
| GO:0001558 | Regulation of cell growth | IEA | biological_process |
| GO:0005520 | Insulin-like growth factor binding | IEA | molecular_function |
| GO:0005576 | Extracellular region | IEA TAS | cellular_component |
| GO:0005615 | Extracellular space | IEA | cellular_component |
| GO:0006987 | Activation of signaling protein activity involved in unfolded protein response | TAS | biological_process |
| GO:0007165 | Signal transduction | TAS | biological_process |
| GO:0008286 | Insulin receptor signaling pathway | IEA | biological_process |
| GO:0030307 | Positive regulation of cell growth | IEA | biological_process |
| GO:0030968 | Endoplasmic reticulum unfolded protein response | TAS | biological_process |
| GO:0042246 | Tissue regeneration | IEA | biological_process |
| GO:0044267 | Cellular protein metabolic process | TAS | biological_process |
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4. Expression levels in datasets
- Meta-analysis result
| p-value up | p-value down | FDR up | FDR down |
|---|---|---|---|
| 0.1674493560 | 0.4238124577 | 0.8073703059 | 1.0000000000 |
- Individual experiment result
( "-" represent NA in the specific microarray platform )
( "-" represent NA in the specific microarray platform )
| Data source | Up or down | Log fold change |
|---|---|---|
| GSE11954 | Up | 0.0824823808 |
| GSE13712_SHEAR | Up | 0.2491847455 |
| GSE13712_STATIC | Down | -0.4795211995 |
| GSE19018 | Up | 0.0661495386 |
| GSE19899_A1 | Down | -0.0340534218 |
| GSE19899_A2 | Up | 0.1055422516 |
| PubMed_21979375_A1 | Up | 0.1451298580 |
| PubMed_21979375_A2 | Down | -0.0423980670 |
| GSE35957 | Down | -1.1654823903 |
| GSE36640 | Down | -0.1041308213 |
| GSE54402 | Down | -0.1088160859 |
| GSE9593 | Up | 1.3552127852 |
| GSE43922 | Up | 0.0685338544 |
| GSE24585 | Down | -0.0031017167 |
| GSE37065 | Up | 0.2944310283 |
| GSE28863_A1 | Down | -0.2388828129 |
| GSE28863_A2 | Up | 0.1729577389 |
| GSE28863_A3 | Up | 0.4322305635 |
| GSE28863_A4 | Down | -0.0024476068 |
| GSE48662 | Up | 0.2248212717 |
5. Regulation relationships with compounds/drugs/microRNAs
- Compounds
Not regulated by compounds
- Drugs
Not regulated by drugs
- MicroRNAs
- mirTarBase
- mirTarBase
MiRNA_name | mirBase ID | miRTarBase ID | Experiment | Support type | References (Pubmed ID) |
|---|---|---|---|---|---|
| hsa-miR-29c-3p | MIMAT0000681 | MIRT006386 | Luciferase reporter assay | Functional MTI | 21436257 |
| hsa-miR-124-3p | MIMAT0000422 | MIRT022268 | Microarray | Functional MTI (Weak) | 18668037 |
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- mirRecord
No target information from mirRecord
- mirRecord
6. Text-mining results about the gene
Gene occurances in abstracts of cellular senescence-associated articles: 2 abstracts the gene occurs.
PubMed ID of the article | Sentenece the gene occurs |
|---|---|
| 26577046 | Overexpression of constitutively active FOXO1 in PR-A-expressing cells conferred robust ligand-dependent upregulation of the PR-B target genes GZMA, IGFBP1, and p21, and induced cellular senescence |
| 24169561 | Knock-down of CRT expression in cultured ESCs significantly inhibited PKA-selective cAMP analog- or PKA-selective cAMP analog plus EPAC-selective cAMP analog-induced PRL and IGFBP1 expression |
| 24169561 | Furthermore, CRT knock-down suppressed the ovarian steroid-stimulated PRL and IGFBP1 expression and morphological differentiation, and silencing of EPAC2 or CRT significantly increased senescence-associated beta-galactosidase activity with enhanced p21 expression and decreased p53 expression |
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