HCSGD entry for IGF2R

1. General information

Official gene symbolIGF2R
Entrez ID3482
Gene full nameinsulin-like growth factor 2 receptor
Other gene symbolsCD222 CIMPR M6P-R MPR1 MPRI
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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This gene isn't in PPI subnetwork.

3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0001889Liver developmentIEAbiological_process
GO:0001948Glycoprotein bindingIDAmolecular_function
GO:0001965G-protein alpha-subunit bindingIEAmolecular_function
GO:0001972Retinoic acid bindingIEAmolecular_function
GO:0004872Receptor activityTASmolecular_function
GO:0004930G-protein coupled receptor activityIEAmolecular_function
GO:0005010Insulin-like growth factor-activated receptor activityTASmolecular_function
GO:0005215Transporter activityIEAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005537Mannose bindingIEAmolecular_function
GO:0005615Extracellular spaceIEAcellular_component
GO:0005641Nuclear envelope lumenIEAcellular_component
GO:0005737CytoplasmIEAcellular_component
GO:0005765Lysosomal membraneIEAcellular_component
GO:0005768EndosomeIDAcellular_component
GO:0005770Late endosomeIEAcellular_component
GO:0005887Integral component of plasma membraneTAScellular_component
GO:0006468Protein phosphorylationTASbiological_process
GO:0006898Receptor-mediated endocytosisTASbiological_process
GO:0007165Signal transductionTASbiological_process
GO:0007283SpermatogenesisIEAbiological_process
GO:0008152Metabolic processTASbiological_process
GO:0009791Post-embryonic developmentIEAbiological_process
GO:0009986Cell surfaceIDAcellular_component
GO:0016021Integral component of membraneIEAcellular_component
GO:0016310PhosphorylationTASbiological_process
GO:0018108Peptidyl-tyrosine phosphorylationTASbiological_process
GO:0019899Enzyme bindingIEAmolecular_function
GO:0030118Clathrin coatIEAcellular_component
GO:0030139Endocytic vesicleIDAcellular_component
GO:0030140Trans-Golgi network transport vesicleIDAcellular_component
GO:0031100Organ regenerationIEAbiological_process
GO:0031995Insulin-like growth factor II bindingIEAmolecular_function
GO:0032526Response to retinoic acidIEAbiological_process
GO:0042802Identical protein bindingIPImolecular_function
GO:0043065Positive regulation of apoptotic processIEAbiological_process
GO:0048009Insulin-like growth factor receptor signaling pathwayTASbiological_process
GO:0048471Perinuclear region of cytoplasmIEAcellular_component
GO:0051219Phosphoprotein bindingIDAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.00510315340.99160042930.18669722221.0000000000

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.4283547518
GSE13712_SHEARDown-0.6122870807
GSE13712_STATICUp0.2476078949
GSE19018Up0.5899672851
GSE19899_A1Up0.2631437432
GSE19899_A2Up0.9101617903
PubMed_21979375_A1Up0.1154143571
PubMed_21979375_A2Up1.0519065178
GSE35957Up0.2652626659
GSE36640Up1.0345216976
GSE54402Down-0.0221834581
GSE9593Up1.3955830782
GSE43922Up0.4909244983
GSE24585Up0.2696699895
GSE37065Down-0.0456554516
GSE28863_A1--
GSE28863_A2--
GSE28863_A3--
GSE28863_A4--
GSE48662Up0.2764714577

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

MecaserminDB01277 -
alpha-D-mannose 6-phosphateDB02900 EXPT02088

  • MicroRNAs

    • mirTarBase

MiRNA_name

mirBase ID

miRTarBase ID

Experiment

Support type

References (Pubmed ID)

hsa-miR-16-5pMIMAT0000069MIRT001451pSILAC//Proteomics;OtherFunctional MTI (Weak)18668040
hsa-miR-657MIMAT0003335MIRT016136Reporter assayFunctional MTI18602895
hsa-miR-155-5pMIMAT0000646MIRT020747ProteomicsFunctional MTI (Weak)18668040
hsa-miR-9-5pMIMAT0000441MIRT021356MicroarrayFunctional MTI (Weak)17612493
hsa-miR-26b-5pMIMAT0000083MIRT029460MicroarrayFunctional MTI (Weak)19088304
hsa-miR-1271-5pMIMAT0005796MIRT036067CLASHFunctional MTI (Weak)23622248
hsa-miR-423-3pMIMAT0001340MIRT042556CLASHFunctional MTI (Weak)23622248
hsa-miR-128-3pMIMAT0000424MIRT045878CLASHFunctional MTI (Weak)23622248
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    • mirRecord

MicroRNA name

mirBase ID

Target site number

MiRNA mature ID

Test method inter

MiRNA regulation site

Reporter target site

Pubmed ID

hsa-miR-657MIMAT0003335NAhsa-miR-657{ELISA}{overexpression by miRNA precursor transfection}18602895
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6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 1 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

24527572OBJECTIVE: To study the profile of IGF2R expression and histone modifications in replicative cell senescence
24527572METHODS: The changes of biological characteristics of young human pulmonary fibroblast (HPF) cells [at population doubling level (PDL) 23] and aging HPF cells (at PDL50) were observed and real-time quantitative PCR was utilized to investigate human IGF2R gene expressions profile during the process of cellular aging (at different PDL)
24527572Then chromatinimmunoprecipitation-real time quantitative PCR (CHIP-QPCR) methods were conducted to analyze histone modifications of the regions around the transcriptional start site of IGF2R (H3-Ac, H3K9-tri-Me, H3K9-Ac and H3K4-tri-Me)
24527572IGF2R gene expression was in positive correlation with PDL
24527572CONCLUSION: IGF2R is related to cell replicative senescence and its gene expression is regulated by histone modification of H3
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