HCSGD entry for APOE

1. General information

Official gene symbolAPOE
Entrez ID348
Gene full nameapolipoprotein E
Other gene symbolsAD2 LDLCQ5 LPG
Links to Entrez GeneLinks to Entrez Gene

2. Neighbors in the network

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3. Gene ontology annotation

GO ID

GO term

Evidence

Category

GO:0000302Response to reactive oxygen speciesNASbiological_process
GO:0001523Retinoid metabolic processTASbiological_process
GO:0001540Beta-amyloid bindingIDAmolecular_function
GO:0001937Negative regulation of endothelial cell proliferationIDAbiological_process
GO:0002021Response to dietary excessIEAbiological_process
GO:0005319Lipid transporter activityIDAmolecular_function
GO:0005515Protein bindingIPImolecular_function
GO:0005543Phospholipid bindingIDA IEAmolecular_function
GO:0005576Extracellular regionIEA TAScellular_component
GO:0005615Extracellular spaceIDAcellular_component
GO:0005737CytoplasmNAS TAScellular_component
GO:0005769Early endosomeTAScellular_component
GO:0005770Late endosomeIEAcellular_component
GO:0005794Golgi apparatusIEAcellular_component
GO:0005886Plasma membraneTAScellular_component
GO:0006641Triglyceride metabolic processIDA IMPbiological_process
GO:0006707Cholesterol catabolic processIEAbiological_process
GO:0006869Lipid transportIEAbiological_process
GO:0006874Cellular calcium ion homeostasisIEAbiological_process
GO:0006898Receptor-mediated endocytosisIDAbiological_process
GO:0006979Response to oxidative stressIEAbiological_process
GO:0007010Cytoskeleton organizationTASbiological_process
GO:0007186G-protein coupled receptor signaling pathwayIDAbiological_process
GO:0007263Nitric oxide mediated signal transductionIDAbiological_process
GO:0007271Synaptic transmission, cholinergicTASbiological_process
GO:0007568AgingIEAbiological_process
GO:0007603Phototransduction, visible lightTASbiological_process
GO:0008201Heparin bindingIDAmolecular_function
GO:0008203Cholesterol metabolic processIDA IMPbiological_process
GO:0008219Cell deathIEAbiological_process
GO:0008289Lipid bindingIDA IEAmolecular_function
GO:0010468Regulation of gene expressionIEAbiological_process
GO:0010544Negative regulation of platelet activationIDAbiological_process
GO:0010873Positive regulation of cholesterol esterificationIDA IEAbiological_process
GO:0010875Positive regulation of cholesterol effluxIDA IGIbiological_process
GO:0014012Peripheral nervous system axon regenerationIEAbiological_process
GO:0016209Antioxidant activityIDAmolecular_function
GO:0017127Cholesterol transporter activityIEAmolecular_function
GO:0019934CGMP-mediated signalingIDAbiological_process
GO:0030195Negative regulation of blood coagulationIDAbiological_process
GO:0030425DendriteIEA NAScellular_component
GO:0030516Regulation of axon extensionTASbiological_process
GO:0030828Positive regulation of cGMP biosynthetic processIDAbiological_process
GO:0031232Extrinsic component of external side of plasma membraneIEAcellular_component
GO:0032489Regulation of Cdc42 protein signal transductionIDAbiological_process
GO:0032526Response to retinoic acidIEAbiological_process
GO:0032805Positive regulation of low-density lipoprotein particle receptor catabolic processIDAbiological_process
GO:0032868Response to insulinIEAbiological_process
GO:0033344Cholesterol effluxIDA IEAbiological_process
GO:0033700Phospholipid effluxIDAbiological_process
GO:0034361Very-low-density lipoprotein particleIDAcellular_component
GO:0034362Low-density lipoprotein particleIDA IEAcellular_component
GO:0034363Intermediate-density lipoprotein particleIDAcellular_component
GO:0034364High-density lipoprotein particleIDAcellular_component
GO:0034372Very-low-density lipoprotein particle remodelingIDA IEA IGIbiological_process
GO:0034374Low-density lipoprotein particle remodelingIEAbiological_process
GO:0034375High-density lipoprotein particle remodelingIGIbiological_process
GO:0034380High-density lipoprotein particle assemblyIDAbiological_process
GO:0034382Chylomicron remnant clearanceIMPbiological_process
GO:0034384High-density lipoprotein particle clearanceIDAbiological_process
GO:0034447Very-low-density lipoprotein particle clearanceIDA IMPbiological_process
GO:0042157Lipoprotein metabolic processIEA TASbiological_process
GO:0042158Lipoprotein biosynthetic processIEAbiological_process
GO:0042159Lipoprotein catabolic processIEAbiological_process
GO:0042311VasodilationIEAbiological_process
GO:0042627ChylomicronIDAcellular_component
GO:0042632Cholesterol homeostasisIDA IEAbiological_process
GO:0042802Identical protein bindingIDAmolecular_function
GO:0042803Protein homodimerization activityIDAmolecular_function
GO:0043025Neuronal cell bodyIEA NAScellular_component
GO:0043407Negative regulation of MAP kinase activityIDAbiological_process
GO:0043524Negative regulation of neuron apoptotic processIEAbiological_process
GO:0043537Negative regulation of blood vessel endothelial cell migrationIDAbiological_process
GO:0043691Reverse cholesterol transportIDAbiological_process
GO:0044281Small molecule metabolic processTASbiological_process
GO:0045471Response to ethanolIEAbiological_process
GO:0045541Negative regulation of cholesterol biosynthetic processIDAbiological_process
GO:0045773Positive regulation of axon extensionIEAbiological_process
GO:0046848Hydroxyapatite bindingIEAmolecular_function
GO:0046907Intracellular transportTASbiological_process
GO:0046911Metal chelating activityIDAmolecular_function
GO:0046982Protein heterodimerization activityIPImolecular_function
GO:0048156Tau protein bindingIPImolecular_function
GO:0048168Regulation of neuronal synaptic plasticityTASbiological_process
GO:0048709Oligodendrocyte differentiationIEAbiological_process
GO:0048844Artery morphogenesisIEAbiological_process
GO:0050728Negative regulation of inflammatory responseIC IEAbiological_process
GO:0050750Low-density lipoprotein particle receptor bindingIDA IPImolecular_function
GO:0051000Positive regulation of nitric-oxide synthase activityIDAbiological_process
GO:0051044Positive regulation of membrane protein ectodomain proteolysisIDAbiological_process
GO:0051651Maintenance of location in cellIEAbiological_process
GO:0060228Phosphatidylcholine-sterol O-acyltransferase activator activityIDA IEAmolecular_function
GO:0070326Very-low-density lipoprotein particle receptor bindingIDA IPImolecular_function
GO:0071347Cellular response to interleukin-1IEAbiological_process
GO:0071363Cellular response to growth factor stimulusIEAbiological_process
GO:0071397Cellular response to cholesterolIEAbiological_process
GO:0071682Endocytic vesicle lumenTAScellular_component
GO:0071813Lipoprotein particle bindingIEAmolecular_function
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4. Expression levels in datasets

  • Meta-analysis result

p-value upp-value downFDR upFDR down
0.37128668360.25689267130.99999024730.9719942537

  • Individual experiment result
    ( "-" represent NA in the specific microarray platform )

Data sourceUp or downLog fold change
GSE11954Up0.1036006055
GSE13712_SHEARDown-0.4509949259
GSE13712_STATICUp0.0210975552
GSE19018Down-0.0291061071
GSE19899_A1Down-0.0085356968
GSE19899_A2Down-0.2909357960
PubMed_21979375_A1Down-0.0698769962
PubMed_21979375_A2Down-0.2245397118
GSE35957Down-0.1300888201
GSE36640Up0.1741624012
GSE54402Up0.0183230900
GSE9593Down-0.5284528199
GSE43922Down-0.0513166242
GSE24585Up0.7728711218
GSE37065Down-0.2273108988
GSE28863_A1Up0.0822867427
GSE28863_A2Up0.2560544382
GSE28863_A3Up0.3424356318
GSE28863_A4Up0.0274096597
GSE48662Up0.0944423098

5. Regulation relationships with compounds/drugs/microRNAs

  • Compounds

Not regulated by compounds

  • Drugs

Name

Drug

Accession number

Human Serum AlbuminDB00062 BTD00059 | BIOD00059
Serum albumin iodonatedDB00064 BTD00089 | BIOD00089

  • MicroRNAs

    • mirTarBase
No target information from mirTarBase
    • mirRecord
No target information from mirRecord

6. Text-mining results about the gene

Gene occurances in abstracts of cellular senescence-associated articles: 10 abstracts the gene occurs.


PubMed ID of the article

Sentenece the gene occurs

26677855In a standard GWAS analysis, only one locus in these studies is significant (APOE/TOMM40) when controlling the false discovery rate (FDR) at 10%
26677855The loci that replicated (FDR < 5%) included APOE/TOMM40 (associated with Alzheimer's disease), CDKN2B/ANRIL (implicated in the regulation of cellular senescence), ABO (tags the O blood group), and SH2B3/ATXN2 (a signaling gene that extends lifespan in Drosophila and a gene involved in neurological disease)
26476632Food supplementation with rice bran enzymatic extract prevents vascular apoptosis and atherogenesis in ApoE-/- mice
26476632METHODS: Seven-week-old male ApoE-/- mice were fed high-fat diet (HFD) or isocaloric HFD supplemented with 5 % (w/w) RBEE for 23 weeks
2647663235 apoptotic nuclei/ring for ApoE-/- HFD and ApoE-/- HFD 5 % RBEE, respectively)
26476632Compared to WT, ApoE-/- mice on HFD were characterized by significant telomere shortening in aorta (11 +/- 2 %) and MNC (73 +/- 7 %), which was reduced by supplementation with RBEE (aorta: 40 +/- 7 %; MNC: 105 +/- 10 %)
26476632CONCLUSION: Long-term food supplementation with RBEE lowers cholesterol and prevents atherosclerotic plaque development in ApoE-/- mice
26414604In the ApoE(-/-) mouse model of atherosclerosis, forced expression of PGC-1alpha increased expression of TERT, extended telomeres, and reversed genomic DNA damage, vascular senescence, and the development of atherosclerotic plaques
23832324METHODS AND RESULTS: In vitro studies were performed on VSMCs isolated from human umbilical veins, whereas in vivo studies were performed on atherosclerosis-prone apolipoprotein E-deficient (ApoE(-/-)) mice
23832324Furthermore, genetic ablation of Arg-II in ApoE(-/-) mice reduced the aforementioned signaling and apoptotic VSMCs in the plaque of aortic roots
23418430Further analyses revealed a modulatory effect of hormone therapy on the association between APOE status and telomere attrition
23224247ApoE(-/-) mice expressing SIRT1(Deltaex4) only in smooth muscle cells demonstrated increased DNA damage response activation and apoptosis, increased atherosclerosis, reduced relative fibrous cap thickness, and medial degeneration
20031273There was a borderline statistically significant interaction for telomere length and APOE e4 on 3MS change score (p=0
19932479CONCLUSIONS/INTERPRETATION: Intravenous autologous BMC and HS intervention together with MT increased therapeutic angiogenesis in the ApoE(-/-) diabetic mouse hindlimb
18468826Apolipoprotein E, an important player in longevity and age-related diseases
18468826We then discuss the known involvement of apolipoprotein E (ApoE) in various symptoms of the human aging process and describe the corresponding age-related phenotypes presented by the ApoE knockout mouse
9033259In addition to aging, inheritance of the epsilon 4 allele of APOE is the other major risk factor for development of late-onset AD; however, the mechanisms through which aging and apolipoprotein E isoforms may collaborate in the onset or progression of AD are not known
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